Protein Alignment Vps13 and VPS13D

DIOPT Version :10

• Sequence 1: NP_610299.2
• Gene: Vps13 / 35693
• FlyBaseID: FBgn0033194
• Length: 3321
• Species: Drosophila melanogaster
• Sequence 2: NP_056193.2
• Gene: VPS13D / 55187
• HGNCID: 23595
• Length: 4388
• Species: Homo sapiens
• Alignment Length: 4580
• Identity: 848/4580 - (18%)
• Similarity: 1483/4580 - (32%)
• Gaps: 1625/4580 - (35%)

  Fly     2 VFEAVVADVLNKVLGDYIENLDRNQLKIGIWGGDVVLQNLKIRENALDELDLPVQLIYGYLGKLV 66
            :.|.:||.|||..||.|:.||:.:||.:.:..|.|.|:||.::::||.||:||.::..|::||:.
Human     1 MLEGLVAWVLNTYLGKYVNNLNTDQLSVALLKGAVELENLPLKKDALKELELPFEVKAGFIGKVT 65

  Fly    67 LKIPWKNLYSQPVIVNIEDLYVLVSPNNNVQYNAEKEAKYEMDLKKAALDALEAARKKELEMDQP 131
            |:||:...:..|.:::|..|:::.:|.....:|.|||...|.:.|||.|.|||...|.:.:....
Human    66 LQIPFYRPHVDPWVISISSLHLIGAPEKIQDFNDEKEKLLERERKKALLQALEEKWKNDRQQKGE 130

  Fly   132 KADAGFAEKLTAQIVNNLQVQITNVHLRYEDTTTTGS-PFSFGISLHELELYTTDCDWEKCYMAQ 195
            .........:..:||.|::::|.:||||:||..|..| ||:|||.:..:.:.....:..:..|.:
Human   131 SYWYSVTASVVTRIVENIELKIQDVHLRFEDGVTNPSHPFAFGICIKNVSMQNAVNEPVQKLMRK 195

  Fly   196 QASQVFKIANLSCLSAYLNCGGQLYANNKSDLSQ-QFKTNIACKETKPNYNYVLGPISCNAKLKL 259
            :...|.:      .|.|.:....|.    .||.| :.:..:|......:::|||.|:..:|.||.
Human   196 KQLDVAE------FSIYWDVDCTLL----GDLPQMELQEAMARSMESRSHHYVLEPVFASALLKR 250

  Fly   260 NMNPELDDPPF---EKPKIDLTLEMEKLNVGLTNTQFDNLMKLGDAMNRQQLGIPYRKYRPYNIP 321
            |.:.:    |.   ..|:||..:::|.:.:.|:..|:..:|:....:.|::..:.:|:::| .:.
Human   251 NCSKK----PLRSRHSPRIDCDIQLETIPLKLSQLQYRQIMEFLKELERKERQVKFRRWKP-KVA 310

  Fly   322 YKGHARDWWHFAITSILEEEVRKPRESWTWGHIKTHRER-CNTYAQKYKEQCLSKKPSAVLT--- 382
            ...:.|:||:||:.:.| .|:|:.|:..||..: .||.| ..:|..||    .:|....:|:
Human   311 ISKNCREWWYFALNANL-YEIREQRKRCTWDFM-LHRARDAVSYTDKY----FNKLKGGLLSTDD 369

  Fly   383 --ETCRLLETELDVFNLLLIRQRVNIEIAKQRE-----------------AVPEQKSG------- 421
              |.|| :|.|.....|.::|:.|:....||.|                 ..||...|
Human   370 KEEMCR-IEEEQSFEELKILRELVHDRFHKQEELAESLREPQFDSPGACPGAPEPGGGSGMLQYL 433

  Fly   422 --WFSGW-GWGGGAKKDDQTTSQKLVEKFEAAMTSEEKEKMY--RAIGYQENAKPTD-------- 473
              ||.|| ||.|     .||....:||    .:::|::|:..  ..:|.:|...||.
Human   434 QSWFPGWGGWYG-----QQTPEGNVVE----GLSAEQQEQWIPEEILGTEEFFDPTADASCMNTY 489

  Fly   474 LPESYEAIRMNFKLIALEVGLYKDERNSSAATKDFHELPSLVLLNFSMATALITQRPAAEAISII 538
            ....:...::|.:|....|.|...|:    .|...:| .:.:.|.||....|....|...
Human   490 TKRDHVFAKLNLQLQRGTVTLLHKEQ----GTPQMNE-SAFMQLEFSDVKLLAESLPRRN----- 544

  Fly   539 AGMREIKVTGL------TRNDYTPLLV-------ESKITDEFNL--------------------L 570
            :.:..:::.||      |.....||||       ..:::..|.|                    .
Human   545 SSLLSVRLGGLFLRDLATEGTMFPLLVFPNPQKEVGRVSQSFGLQTTSADRSDHYPAADPDGPVF 609

  Fly   571 EVFFETNPLDKLCDQRVKVVARPLQITYDAPTILALINAFQTPGDVTLSKF----------EDAA 625
            |:.:|.||.....::|:.|..|||.|.|: |..:..:..|...|.|..|.|          .:||
Human   610 EMLYERNPAHSHFERRLNVSTRPLNIIYN-PQAIKKVADFFYKGKVHTSGFGYQSELELRVAEAA 673

  Fly   626 STKISNFKERSATGMQYMIDKKAVLD-----------VDILLMPNILVVPHKGVYDAGNVSLLVV 679
            ..:.:..|.::...::..:|:..|.|           :|| ..|.: :.|..  :...|..|:||
Human   674 RRQYNKLKMQTKAEIRQTLDRLLVGDFIEESKRWTVRLDI-SAPQV-IFPDD--FKFKNPVLVVV 734

  Fly   680 SMGQVHLSS---QPRRESNKLQHLFSAGED---KDEILKT------------------------- 713
            .:|::.|::   ..||:|..    .||.|:   .|:..||
Human   735 DLGRMLLTNTQDNSRRKSRD----GSASEETQFSDDEYKTPLATPPNTPPPESSSSNGEKTPPFS 795

  Fly   714 -------------VMENAYDRFTVAVDDVQMLVVRAGEPWQNALAEANSTEMHVLRP--VSLKVT 763
                         :....|:|::::..|:|::|.|..:.|:: :.:.:....||:..  |.|::.
Human   796 GVEFSEEQLQAHLMSTKMYERYSLSFMDLQIMVGRVKDNWKH-VQDIDVGPTHVVEKFNVHLQLE 859

  Fly   764 AALCVVDNDPRLPNIKVDIDLPAILVNVSEDRIFLAIKVATSIPLPEQK---------------- 812
            ..| :..:||:.|...:..:||.:.::::||:|.........:..||.|
Human   860 RRL-IYTSDPKYPGAVLSGNLPDLKIHINEDKISALKNCFALLTTPEMKTSDTQIKEKIFPQEEQ 923

  Fly   813 -----EPASRLTQT--------------------------------------------------- 821
                 :....|||:
Human   924 RGSLQDSVMNLTQSIVLLEQHTREVLVESQLLLAEFKVNCMQLGVESNGRYISVLKVFGTNAHFV 988

  Fly   822 ----------------------------------------------------------------- 821
                                                                             
Human   989 KRPYDAEVSLTVHGLLLVDTMQTYGADFDLLMASHKNLSFDIPTGSLRDSRAQSPVSGPNVAHLT 1053

  Fly   822 -----NSRSSMSIS-----------------NFINKE---------------------------- 836
                 |.||:.|:|                 .|::.|
Human  1054 DGATLNDRSATSVSLDKILTKEQESLIKLEYQFVSSECPSMNLDSTLQVISLQVNNLDIILNPET 1118

  Fly   837 -VKKIGPSASGSSASKD-----PLLDE-------------------------------------- 857
             |:.||.........||     ||:.:
Human  1119 IVELIGFLQKSFPKEKDDLSPQPLMTDFERSFREQGTYQSTYEQNTEVAVEIHRLNLLLLRTVGM 1183

  Fly   858 ---------------------IIQYTSLDVNFSLG------------------------------ 871
                                 :...::.|:|.|||
Human  1184 ANREKYGRKIATASIGGTKVNVSMGSTFDMNGSLGCLQLMDLTQDNVKNQYVVSIGNSVGYENII 1248

  Fly   872 ------EINFVLFQ---------------SSRKC------------------------------- 884
                  |..||..:               |.::|
Human  1249 SDIGYFESVFVRMEDAALTEALSFTFVERSKQECFLNLKMASLHYNHSAKFLKELTLSMDELEEN 1313

  Fly   885 ---------------------ETSPDVSIEFLTPDGDVLPSQLTE-------------------- 908
                                 |.|..||: |.||.....|..|.|
Human  1314 FRGMLKSAATKVTTVLATKTAEYSEMVSL-FETPRKTREPFILEENEIYGFDLASSHLDTVKLIL 1377

  Fly   909 --NIQEPIEELP--PTPPQQI-----------------------LSIDIRRL------------- 933
              ||:.|:..:|  |..|:.:                       |.::|:.:
Human  1378 NINIESPVVSIPRKPGSPELLVGHLGQIFIQNFVAGDDESRSDRLQVEIKDIKLYSLNCTQLAGR 1442

  Fly   934 ------------------------EAHFVSKTY-----------------------------ESV 945
                                    ||||....:                             ||.
Human  1443 EAVGSEGSRMFCPPSGSGSANSQEEAHFTRHDFFESLHRGQAFHILNNTTIQFKLEKIPIERESE 1507

  Fly   946 ATVKLG--DI---------------------------------------NLRQY-------DCQD 962
            .|..|.  |:                                       :|.:|       .|.|
Human  1508 LTFSLSPDDLGTSSIMKIEGKFVNPVQVVLAKHVYEQVLQTLDNLVYSEDLNKYPASATSSPCPD 1572

  Fly   963 SDMDVLDVIYTPKQENSSNYLFTVSCTIADKSSPEFSTK-YNSTEQ------------------- 1007
            |.:..|........|...|.||:.| ::::.|....|.| ..|..|
Human  1573 SPLPPLSTCGESSVERKENGLFSHS-SLSNTSQKSLSVKEVKSFTQIQATFCISELQVQLSGDLT 1636

  Fly  1008 --------LVVANFEV-----------LQIVLHQECLQRIMEVVNNFQRNLDLVLSSTRPR---- 1049
                    |...:|||           :||.||...::.::| .|...:..:|::|...|:
Human  1637 LGAQGLVSLKFQDFEVEFSKDHPQTLSIQIALHSLLMEDLLE-KNPDSKYKNLMVSRGAPKPSSL 1700

  Fly  1050 -------DRMGSIGGGD--GIKRTLNVILEDTEEIM------TTDQMKRRKK------------- 1086
                   ....|:...:  .:.|:|...:|:...:.      |:...|::|:
Human  1701 AQKEYLSQSCPSVSNVEYPDMPRSLPSHMEEAPNVFQLYQRPTSASRKKQKEVQDKDYPLTPPPS 1765

  Fly  1087 --------------------------------------------------------TRRTHVV-- 1093
                                                                    |.:|.||
Human  1766 PTVDEPKILVGKSKFDDSLVHINIFLVDKKHPEFSSSYNRVNRSIDVDFNCLDVLITLQTWVVIL 1830

  Fly  1094 ----------------------ETVKVRVIANLD----------------QVGLVLTGRKRPIAE 1120
                                  ..||:...|:::                .:.|||......:|:
Human  1831 DFFGIGSTADNHAMRLPPEGILHNVKLEPHASMESGLQDPVNTKLDLKVHSLSLVLNKTTSELAK 1895

  Fly  1121 MNVKKFVSSLIIKSSYTEVNIGLK-DIQVLDLNPYTIH----KNILSIVGKDAFNCQIVIYNKEE 1180
            .||.|.|:.|    ...|.::.|: .|..|.|:..|.|    :...:..|::|...|...|.:.:
Human  1896 ANVSKLVAHL----EMIEGDLALQGSIGSLSLSDLTCHGEFYRERFTTSGEEALIFQTFKYGRPD 1956

  Fly  1181 TQDYNSDDMKITVDIGCMKIIFLNWFVAGVMNFLNNFTAAQATIS-QAGAAAAESARQKAMDAYE 1244
            .......|:::::.:..::.:....|.|.|:.|:.:||..|..:. |..|...::.|.:|    :
Human  1957 PLLRREHDIRVSLRMASVQYVHTQRFQAEVVAFIQHFTQLQDVLGRQRAAIEGQTVRDQA----Q 2017

  Fly  1245 TATRMKLNIRIKAPIIIVPIGSQDRNALLLDLGLLELTNN------------------------- 1284
            ..:|:.|:|...||::::|..|:..|.::.:||.|::.|.
Human  2018 RCSRVLLDIEAGAPVLLIPESSRSNNLIVANLGKLKVKNKFLFAGFPGTFSLQDKESVPSASPTG 2082

  Fly  1285 -----------------------------------------------------TVEV---AVAEE 1293
                                                                 |:.|   :.:.|
Human  2083 IPKHSLRKTTSTEEPRGTHSQGQFTMPLAGMSLGSLKSEFVPSTSTKQQGPQPTLSVGQESSSPE 2147

  Fly  1294 ERLAVIDEIKLQICDVKI----------SKIVLLDGNESTVDEVDAEVGFLSKF-------NMMN 1341
            :.:.::|.:.:.:.|:.|          ||         ..::...::.|.|.|       .:..
Human  2148 DHVCLLDCVVVDLQDMDIFAAERHPREYSK---------APEDSSGDLIFPSYFVRQTGGSLLTE 2203

  Fly  1342 PMSCTLSITRNLSYTWYRDVPELNLSGRLKSIELTLFADDYALVMLVLNRNLNEGLEEFPPSEEA 1406
            |....|.:.|||.......||::::.|.|.|:..:|....|.|:..:|..||.|.:|||
Human  2204 PCRLKLQVERNLDKEISHTVPDISIHGNLSSVHCSLDLYKYKLIRGLLENNLGEPIEEF------ 2262

  Fly  1407 PQEAQVRP-ERRNSRAGRLSRTVQVSPIREKIHESIKFNFQFDGVVINLME---GEGAG-LARFG 1466
                 :|| :.::.|.    .||    :..:::..:.|......|.:.|.:   .|||| ||||.
Human  2263 -----MRPYDLQDPRI----HTV----LSGEVYTCMCFLIDMVNVSLELKDPKRKEGAGSLARFD 2314

  Fly  1467 IYFLSVKGTKLDNGTLSTSVVLCNIQMDDMRSNSKSQIRQYLSRKDWVQPKLDTDEIIDACY--- 1528
            .....:......|.|.|.::|..::...|.|         |..:|  ..|.:..   :.:|.
Human  2315 FKKCKLLYESFSNQTKSINLVSHSMMAFDTR---------YAGQK--TSPGMTN---VFSCIFQP 2365

  Fly  1529 ------NERNFMVDVTAIIKEDDTFAEVRVRGFDLIVCIDFLLKLTTFLTLPPEENPRESVYIKP 1587
                  .:.:..:::.....:|.:...|.:....:.:..|:||.:..||..|.:...:..|
Human  2366 AKNSSTTQGSIQIELHFRSTKDSSCFTVVLNNLRVFLIFDWLLLVHDFLHTPSDIKKQNHV---- 2426

  Fly  1588 APVSETARDTKHSIRSSAIL--AAQELVPVESSSHEVPN-RKMNLILHIDEPDIILVENLEDLNT 1649
                 |....::|...|||:  ..:..|..:.||..|.| |.:.:.:::...:.:::|::...:|
Human  2427 -----TPSRHRNSSSESAIVPKTVKSGVVTKRSSLPVSNERHLEVKVNVTGTEFVVIEDVSCFDT 2486

  Fly  1650 SCIIFNAQVHLNYRSINDKQIVNGQIDALKMYMCAFLPERREMTRHYILHPCVISLQ----GSTP 1710
            :.||......|.|:.....:..:|.:..::::.|....|..  |...|:.|..|.::    .|..
Human  2487 NAIILKGTTVLTYKPRFVDRPFSGSLFGIEVFSCRLGNEHD--TALSIVDPVQIQMELVGNSSYQ 2549

  Fly  1711 EEEG-------------MHISLKLSDIIINVSPATIELL---------------NKAMLSVSSGT 1747
            ...|             :.|.|:..||.::.:...:.|.               :.|:.|.|.||
Human  2550 NSSGLMDAFNSEDFPPVLEIQLQALDIRLSYNDVQLFLAIAKSIPEQANAAVPDSVALESDSVGT 2614

  Fly  1748 MTKCA--IAEESRNYSNLWHQHHFH-------SRTYWFTKVEQGVDALEAEQRSVSTDNEKQKTE 1803
            ....|  :.||.|..:    :|...       :|..     |.|....:..:..::...:.:|..
Human  2615 YLPGASRVGEEIREGT----RHTLDPVLELQLARLQ-----ELGFSMDDCRKALLACQGQLKKAA 2670

  Fly  1804 KCVIE----IPSITLVIES--GVGYYTKPLIS-----------------LDTRITAVFNNWSR-- 1843
            ..:.:    :.|::|...|  ..|....||||                 :|..:......:||
Human  2671 SWLFKNAEPLKSLSLASTSRDSPGAVAAPLISGVEIKAESVCICFIDDCMDCDVPLAELTFSRLN 2735

  Fly  1844 -------SLTAHGSLTLNMNYYNQALAEWEPIIELNEVIGRNGVREYTPWELKFEMGMEKVQSEL 1901
                   |...:...||:.:|||:||:.|||.||              ||......     |.:.
Human  2736 FLQRVRTSPEGYAHFTLSGDYYNRALSGWEPFIE--------------PWPCSVSW-----QQQA 2781

  Fly  1902 EDDAEQQAMHMNIHSAETLEITLSKTCLGLLSELAEAFSQAIDQNGLTKPDIVAPYV-------- 1958
            ........:.:...:...|:|.::              |..|||...||...:|.|.
Human  2782 ASRLHPPRLKLEAKAKPRLDINIT--------------SVLIDQYVSTKESWMADYCKDDKDIES 2832

  Fly  1959 --LENDTGFDVN---------------------LNLRKGIFTLHEV----------------HRG 1984
              .|:..|..|:                     .||...|:...||                |.|
Human  2833 AKSEDWMGSSVDPPCFGQSLPLVYLRTRSTASLTNLEHQIYARAEVKTPKRRQPFVPFALRNHTG 2897

  Fly  1985 GTPVGA--NSTLLMVAQSEEVDPSVI---------KTCTIS------TGGRAYLQTKDLSTLSEE 2032
            .|...|  .:|....|.|....|.|:         .|..:|      ||.....:.:....|...
Human  2898 CTLWFATLTTTPTRAALSHSGSPGVVPEGNGTFLDDTHNVSEWREVLTGEEIPFEFEARGKLRHR 2962

  Fly  2033 DSED---YTLYVTIGDINKEIALPVSKSDTRFF-------NLMRST------------------S 2069
            .:.|   :.|.|.:....:...:.|.|..| ||       |...||                  |
Human  2963 HTHDLRIHQLQVRVNGWEQVSPVSVDKVGT-FFRYAAPDKNSSSSTIGSPSSRTNIIHPQVYFSS 3026

  Fly  2070 HEPWGIISEVKQEYGTTKV-NIHGVVSVHNHFTTGLNIYRRNP-APTAQCFEDIFVGRVRPGEVF 2132
            ..|..::..|..|....|| .:...:.|.|...|.:.:...:| ||.    :.:.:..:.||:.|
Human  3027 LPPVRVVFAVTMEGSARKVITVRSALIVRNRLETPMELRLDSPSAPD----KPVVLPAIMPGDSF 3087

  Fly  2133 HVPLH----AIYAESKDL--FFSMRGYRRSVQGISW------ASNPSDLNYSHQLHCDPTNTFEP 2185
            .||||    .:.|..|.|  ||..       ..|.|      |...|.....|.:..:.:..|..
Human  3088 AVPLHLTSWRLQARPKGLGVFFCK-------APIHWTNVVKTAEISSSKRECHSMDTEKSRFFRF 3145

  Fly  2186 LIMNARRSKSEVY--------FENTNKYTLLSAFYTIHLRPPLYLRNSLPINIQVSVAGCSVR-- 2240
            .:    ..|.|.|        |.::.|.......:||:|.|.:.:.|.||..:...|.|..:.
Human  3146 CV----AIKKENYPDYMPSNIFSDSAKQIFRQPGHTIYLLPTVVICNLLPCELDFYVKGMPINGT 3206

  Fly  2241 ----KEDGLDAQSSQRFVDRGYRKEDFLDYGEKPVNSGDVLHLPTVRLASKGKESKSFLVVRLVQ 2301
                ||..|....:.:.::.|...|:|....|..:..|...::..:||....:...: |.:|:|
Human  3207 LKPGKEAALHTADTSQNIELGVSLENFPLCKELLIPPGTQNYMVRMRLYDVNRRQLN-LTIRIV- 3269

  Fly  2302 YLEKDWSCATEIWDYTDDVITWTFSSYDSEMKVDMDLYVKTENRHGSLMLTLFSPFWMINKTGMM 2366
                   |..|                                  |||.:.:.:|:|:|||||:.
Human  3270 -------CRAE----------------------------------GSLKIFISAPYWLINKTGLP 3293

  Fly  2367 LTYKSETTSVEVLYHPPEYS-----GPILFTFRDKLFFDKKKASIRIDNG-------QWSEKIPL 2419
            |.::.:....:......|:.     .|:||.:.||  ......::||..|       .|.:...|
Human  3294 LIFRQDNAKTDAAGQFEEHELARSLSPLLFCYADK--EQPNLCTMRIGRGIHPEGMPGWCQGFSL 3356

  Fly  2420 DVAGSVGEVICFANNQK----YPVGVHNHLTQNSL--TKQITFIPFYIVCNKCHFDI-----ELQ 2473
            |....|..:.......:    |.:|:.....:...  |..:.|.|.|::.||....:     |..
Human  3357 DGGSGVRALKVIQQGNRPGLIYNIGIDVKKGRGRYIDTCMVIFAPRYLLDNKSSHKLAFAQREFA 3421

  Fly  2474 EQSRPADP--WLHLEPNEMEPL-WPRNDTKNNLVVR---VDGKI-TPAFDFTEVICTLLKLEDS- 2530
            .....|:|  ::...|...... |||||....|.||   |...| :..|:..:.....:.:.|:
Human  3422 RGQGTANPEGYISTLPGSSVVFHWPRNDYDQLLCVRLMDVPNCIWSGGFEVNKNNSFHINMRDTL 3486

  Fly  2531 -KYGGINVDVQTTEGGVY-ITFTDYKPADAPGLLINHTGKQIVYHEKGTKNEHI---LNAKSTIM 2590
             |...:.|:: |..|..| |:|:|......|..:.|.:...:|:.:.|.....:   :...:::.
Human  3487 GKCFFLRVEI-TLRGATYRISFSDTDQLPPPFRIDNFSKVPVVFTQHGVAEPRLRTEVKPMTSLD 3550

  Fly  2591 YAWDDPTGPKML---VFGTNKEETDLKRDGIGEVIMQDGGKVLWVSFL--------DGL------ 2638
            ||||:||.|..:   |.|....|.:...:.     .||..::.:.:|:        .||
Human  3551 YAWDEPTLPPFITLTVKGAGSSEINCNMND-----FQDNRQLYYENFIYIAATYTFSGLQEGTGR 3610

  Fly  2639 ---------------------QRVLLFTE-----------------------------NESIANR 2653
                                 |||:|..:                             ..|.|..
Human  3611 PVASNKAITCAELVLDVSPKTQRVILKKKEPGKRSQLWRMTGTGMLAHEGSSVPHNPNKPSAARS 3675

  Fly  2654 TESTASL------------------------QSITQSIDLR-------IHGI------GLS---- 2677
            ||.:|.|                        :|.||:...|       :||:      |||
Human  3676 TEGSAILDIAGLAAVTDNRYEPLMLRKPDRRRSTTQTWSFREGKLTCGLHGLVVQAKGGLSGLFD 3740

  Fly  2678 ----VINNETGLDIL--------YL--------GVTSSGII----WESKKVT----KNRFKELTI 2714
                |:..:|.:::|        ::        |:.|..:|    ..:.::|    :...:...:
Human  3741 GAEVVLGPDTSMELLGPVPPEQQFINQKMRPGSGMLSIRVIPDGPTRALQITDFCHRKSSRSYEV 3805

  Fly  2715 NENALLEIEYQKYLVHKSVNDVQTYKLDNKFPIDFDLMILKKTVERNLRRSF------YPAIWLS 2773
            :|..:.|.|.||.   |:.:..|..::..:......|.::.|..|..:..|.      |..:..|
Human  3806 DELPVTEQELQKL---KNPDTEQELEVLVRLEGGIGLSLINKVPEELVFASLTGINVHYTQLATS 3867

  Fly  2774 RKSSPFQSQLHVKINRIQVDNQFLDPIFPVVL--APIPPPKSVASTTSLKPFIECSMVQRIMPNS 2836
            .       .|.:.|..:|||||.:....|.:|  .|:.....|..|   .|.::.:.|:....::
Human  3868 H-------MLELSIQDVQVDNQLIGTTQPFMLYVTPLSNENEVIET---GPAVQVNAVKFPSKSA 3922

  Fly  2837 TVRQFKYARILIQEFLFKVDLNFLTAIAEMFAKEVSDEAAAKQFRQDVESIELPLSAFFEEHSLE 2901
            ....:|:..|..|.|..:::...|..:...|..:        |...:||..:..|.....|....
Human  3923 LTNIYKHLMITAQRFTVQIEEKLLLKLLSFFGYD--------QAESEVEKYDENLHEKTAEQGGT 3979

  Fly  2902 EQKSFYDNLHLGPLKIHVSFSMAGSDTKALPGFLGSLVQGVGVTLTDVNDVVFRLAFFEREYQFF 2966
            ..:.:::||.:...:|.:|...:..    ||..|.:|...:|..|....|.|..|..|.|.:.:.
Human  3980 PIRYYFENLKISIPQIKLSVFTSNK----LPLDLKALKSTLGFPLIRFEDAVINLDPFTRVHPYE 4040

  Fly  2967 SQKQLINEITSHYTGQALKQLYVLVLGLDVLGNPYGLVVGLKKGVEDLFYEPFQGAIQGPGEFAE 3031
            :::.:||:|..|:..:.|.|...::..:|.||||.||:..:.:||                   .
Human  4041 TKEFIINDILKHFQEELLSQAARILGSVDFLGNPMGLLNDVSEGV-------------------T 4086

  Fly  3032 GLVL--GVKSLFGHTVGGAAGAVSKITGAMGKGLAALTFDEDYQKKRRQGIQNKPKNFHEGLARS 3094
            ||:.  .|..|..:...|.:.:.:|..|.:..||.. |.|..:|.: |:.|:.......|.|...
Human  4087 GLIKYGNVGGLIRNVTHGVSNSAAKFAGTLSDGLGK-TMDNRHQSE-REYIRYHAATSGEHLVAG 4149

  Fly  3095 SKGLVMGFVDGVTGVVTKPVTGAR-DNGVEGFFKGLGKGAIGLVARPTAGVVDFASGSFEAVKRA 3158
            ..||..|.:.|:|.|:|..|.|.: :.||.||..|||||.:|.|.:|.||.:||||.:.:||:..
Human  4150 IHGLAHGIIGGLTSVITSTVEGVKTEGGVSGFISGLGKGLVGTVTKPVAGALDFASETAQAVRDT 4214

  Fly  3159 ADAS---EDVKRMRPPRFQHYDFVLRP-YCLMEATGNKIMKETDKGKFATTDN-----FIHCEEI 3214
            |..|   ...:|:|.||.......|.| |...:|.|.:.:       |..|||     ||..|.|
Human  4215 ATLSGPRTQAQRVRKPRCCTGPQGLLPRYSESQAEGQEQL-------FKLTDNIQDEFFIAVENI 4272

  Fly  3215 IQKSEYLVVTNYRVM-------YVQRNEMF 3237
               ..|.|:.:.:.:       ||.|..:|
Human  4273 ---DSYCVLISSKAVYFLKSGDYVDREAIF 4299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps13	NP_610299.2	MRS6	4..>1969	CDD:227376	520/3020 (17%)
		VPS13	137..370	CDD:465309	62/238 (26%)
		SHR-BD	2351..2599	CDD:461974	63/283 (22%)
		MRS6	<2701..3232	CDD:227376	136/561 (24%)
		VPS13_C	2904..3074	CDD:465310	41/171 (24%)
VPS13D	NP_056193.2	MRS6	1..>1269	CDD:227376	253/1319 (19%)
		VPS13	137..356	CDD:465309	60/235 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..796		9/54 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1563..1582		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1741..1771		3/29 (10%)
		VPS13_mid_rpt	1964..>2055	CDD:465311	23/94 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2070..2108		0/37 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2122..2145		2/22 (9%)
		MRS6	<2145..>3102	CDD:227376	199/1056 (19%)
		UBA_VP13D	2642..2677	CDD:270491	4/39 (10%)
		SHR-BD	3276..3559	CDD:461974	64/285 (22%)
		beta-trefoil_Ricin_VPS13D	3614..3774	CDD:467331	22/159 (14%)
		MRS6	<3836..4298	CDD:227376	130/514 (25%)