DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13 and Vps13c

DIOPT Version :9

Sequence 1:	NP_001260781.1	Gene:	Vps13 / 35693	FlyBaseID:	FBgn0033194	Length:	3321	Species:	Drosophila melanogaster
Sequence 2:	NP_796158.2	Gene:	Vps13c / 320528	MGIID:	2444207	Length:	3748	Species:	Mus musculus

Alignment Length:	3961	Identity:	1101/3961 - (27%)
Similarity:	1805/3961 - (45%)	Gaps:	890/3961 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFEAVVADVLNKVLGDYIENLDRNQLKIGIWGGDVVLQNLKIRENALDELDLPVQLIYGYLGKL 65
            ||.|:||||:||:.||||:|||:::|||:|||||:|.|.||:|:||||.|||:|.::..|.:.||
Mouse     1 MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAGQIDKL 65

  Fly    66 VLKIPWKNLYSQPVIVNIEDLYVLVSPNNNVQYNAEKEAKYEMDLKKAALDALEAARKKELE--- 127
            .|||||||||.:.|:..:|.||:||.|..:::|:||||.|...|:|:..|..:|.|.:|..|
Mouse    66 TLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAEKEEKSLQDIKQKELCRIEEALQKAAEKGA 130

  Fly   128 ----------------------------------------MDQP---KADAGFAEKLTAQIVNNL 149
                                                    .|:|   |.|. |.|||..|::.|:
Mouse   131 HSGEFMYGLENLLYKDVKPGRKRKKHKKHFKKRFKGLDRSKDKPKEAKKDT-FLEKLATQVIKNV 194

  Fly   150 QVQITNVHLRYEDTTTTGS-PFSFGISLHELELYTTDCDWEKCYMAQQASQVFKIANLSCLSAYL 213
            ||:||::|::|||..|... |.|||::|.|..|.||:..|..|.:.:....::|:..|..||||.
Mouse   195 QVKITDIHIKYEDDITDPERPLSFGVTLREFSLLTTNEHWTPCILNEAEKIIYKLVKLDSLSAYW 259

  Fly   214 NCGGQL-YANNKSDLSQQFK------TNIACKETKPNYNYVLGPISCNAKLKLNMNPELDDPPFE 271
            |.|..: |..::..:.:|.|      |||     .|::.|:..|||.:|||.:|...|.:   .:
Mouse   260 NVGCCMSYRGSREHILEQLKREILTSTNI-----PPDHQYIFQPISASAKLYMNPGAESE---LK 316

  Fly   272 KPKIDLTLEMEKLNVGLTNTQFDNLMKLGDAMNRQQLGIPYRKYRPYNIPYKGHARDWWHFAITS 336
            .||:|..:|::.:.:.||..|:.:::...::::......|||||:|. :|...:.|.||.:||.|
Mouse   317 TPKLDGNVEVQNIAIELTKPQYLSMIDFLESLDYMVRNAPYRKYKPC-LPLHTNCRQWWKYAIDS 380

  Fly   337 ILEEEVRKPRESWTWGHIKTHRERCNTYAQKYKEQCLSKKPSAVLTETCRLLETELDVFNLLLIR 401
            :||..:|:..:.|:|.:||.||:...:|...||.:....|.|..:.:..:.||..|||||::|:|
Mouse   381 VLEVHIRRYTQPWSWSNIKNHRQLLKSYKMAYKTKLTQAKVSEEIQKQIQDLEKSLDVFNIILVR 445

  Fly   402 QRVNIEI------AKQREAVPEQKSGWFSG-WGWGGGAKKDDQTTSQKLVEKFEAAMTSEEKEKM 459
            |:..:|:      .:::.|...:|.||||| ||.....|:|::::   :.|..:..||.|||:|:
Mouse   446 QQAQVEVIHSGQKLRKKSAEAGEKRGWFSGFWGKKESKKRDEESS---VPETIDDLMTPEEKDKL 507

  Fly   460 YRAIGYQENAKPTDLPESYEAIRMNFKLIALEVGLYKDERNSSAATKDFHELPSLVLLNFSMATA 524
            :.||||.|||....||:.|.|..:..||::..: :.::.||          :|.::.:.......
Mouse   508 FTAIGYSENAYNLALPKQYVAHILTLKLVSTSI-IIRENRN----------VPEILRVQIIGLGT 561

  Fly   525 LITQRPAAEAISIIAGMREIKVTGLTRNDYTPLLVESKITDEFNLLEVFFETNPLDKLCDQRVKV 589
            .::|||.|:|:.|.|.:....||||.:.|..|.||.|......:||::.|||||.:...||.:.|
Mouse   562 QVSQRPGAQALKIEAKLEHWYVTGLRQQDIVPSLVASIGDTTSSLLKIEFETNPENSPADQTLIV 626

  Fly   590 VARPLQITYDAPTILALINAFQTPGDVTLSKFEDAASTKISNFKERSATGMQYMIDKKAVLDVDI 654
            .::|:::.|||.||.|::..||:...:.|.:...|...|:...|||:|||:.::|:.:.|||:.|
Mouse   627 QSQPVEVIYDAKTINAVVEFFQSNKGLDLEQITSATLMKLEEIKERTATGLTHIIETRKVLDLRI 691

  Fly   655 LLMPNILVVPHKGVYDAGNVSLLVVSMGQVHLSSQPRRESNKLQHLFSAGEDKDEILKTVMENAY 719
            .|.|:.|::|..|.:...: :||::..|...|:|:.:          .|.:..:..|:.:::.||
Mouse   692 NLKPSYLIIPQTGFHHEKS-NLLILDFGTFQLNSKDQ----------GAQKTANASLEEIIDKAY 745

  Fly   720 DRFTVAVDDVQMLVVRAGEPWQNALAEANSTEMHVLRPVSLKVTAALCVVDNDPRLPNIKVDIDL 784
            |:|.|.:..||:|..:|.|.|:....:..|| ||:|:|:.:.|..|..:|:.|.|:...||...|
Mouse   746 DKFDVEIRSVQLLFAKAEENWKKCRFQHPST-MHILQPMDIHVELAKAMVEKDVRMAKFKVSGGL 809

  Fly   785 PAILVNVSEDRIFLAIKVATSIPLPEQKEPASRLTQTNSRSSMS--------------------- 828
            |.:.|.:|:.:|..|:.:..|||||::....|...|..|...:|
Mouse   810 PLMHVRISDQKIKDALCLINSIPLPQKSSTPSPERQVASIPVLSGGTKALLGTSLLLDGVESESD 874

  Fly   829 ---------------------------------ISNFINKEVKKI-------------------- 840
                                             :|..:..|:|::
Mouse   875 EEFFDAEDGDSQAARTVKASELKKAAEVPNEELVSLLLKFEIKEVVLELTKQQKEEETILVFNVT 939

  Fly   841 --GPSAS-----------------------GS--------SASKDPLLDEI-IQYTSLDVN---- 867
              |..|:                       ||        |:|..|.||.: ::|..:|.|
Mouse   940 QLGTEATMRTFDLTAVSYLRKISLDYHDIKGSRKKPIHLISSSDRPGLDLLKVEYIKVDRNGPSF 1004

  Fly   868 --------------FS-----------LGEINFV------------------------------- 876
                          ||           |..:|::
Mouse  1005 QTTFEKTEQTVKVAFSSLNLLLQTQALLSSLNYLTTVIPSDSQNTGVAKEVQAMPEKQKNSPLQK 1069

  Fly   877 -----------------------------------------------------LF---------- 878
                                                                 ||
Mouse  1070 VMVPSRDSDVIGFRLFAKLNAFCVTVCDEKSNIAEIKIQGLDSSLSLQSKKQSLFARLENIIVTD 1134

  Fly   879 ----------------------------------------------------------------- 878

Mouse  1135 VDPKTIHKKAVSIVGNEVFRFNLDLYPDATEGDSYTDMSTVDGVVALHVGCIQIVYLHKFLMSLL 1199

  Fly   879 ------------------QSSRKCETS-------------------------------------- 887
                              |::.|..||
Mouse  1200 SFLNNFQVAKEALSAATAQAAEKAATSVKDLAQRSFRVSVDIDLKAPVIVIPQSSLSTNAVVVDL 1264

  Fly   888 ----------------------------------------------PD------VSIEFLT---- 896
                                                          ||      :::||..
Mouse  1265 GLIRVHNRFSLVSGEDTANPPVIDKMEVQLTKLKLSRTAIQPGTSHPDIQLLHPINLEFFVSRNL 1329

  Fly   897 --------------------------PDGDVLPSQLTENIQEPIEELPP---------------- 919
                                      .|.::|...|.||:.|..|:|..
Mouse  1330 AANWYHKVPVVEIKGRLDSMNVSLNQEDLNLLFRILAENLGEATEDLDKGKPRIQERGETKACRE 1394

  Fly   920 -TPPQQI-----------------------LSIDIRRLEAHFVS--------------------- 939
             :.||.:                       |:.:|:.:....:.
Mouse  1395 VSTPQDVHTTQGVPAARVEETRPVDIINVLLNFEIKEVVVTLMKKAERKGSPFHELKILHLGMEA 1459

  Fly   940 --KTYESVATVKLGDINLRQYDCQDSDMDVLDVIYTPKQENSSNYLFTVSCTIADKSSPEFSTKY 1002
              |.::..|...|.:|::|.:...||..:.|.::.|  .:.|...|..:....||...|:|.|.:
Mouse  1460 KVKAHDMTAAAYLRNISMRCFHFPDSKGEPLRIVNT--SDVSDGILLKLLFIKADSDGPDFKTIH 1522

  Fly  1003 NSTEQLVVANFEVLQIVLHQECLQRIMEVVNNFQRNLDLVLSSTRPRDRMGSIGGGDGIKRTLNV 1067
            ::|:|.:..:|..|.:|||.|.|..:|:.:::...:.|...|...|.               |..
Mouse  1523 DNTKQKLKVSFSSLDLVLHLEALLSLMDFLSSAIPSSDSSSSEKEPE---------------LKP 1572

  Fly  1068 ILEDTEEIMTTDQMKRRKKTRRTHVVETVKVRVIANLDQVGLVLTGRKRPIAEMNVKKFVSSLII 1132
            ::.::..:..       :....::..:...:::.|.|:...:.:..:|..|||:.:....:|:.:
Mouse  1573 LVGESRSLAI-------RAVPSSYEGDAFDLKITAELNAFNIFICDQKSNIAEIKIHGMDASISV 1630

  Fly  1133 KSSYTEVNIGLKDIQVLDLNPYTIHKNILSIVGKDAFNCQIVIYNKEETQDYNSDDM-----KIT 1192
            |...|:|...||:|.|::::..:|||..:||:|.:.|..|:.:| .:.|:..|..||     :::
Mouse  1631 KPKQTDVFARLKNIIVMNVDSLSIHKKAVSILGDEVFRFQMSLY-PDATEGENYGDMSKVDGRLS 1694

  Fly  1193 VDIGCMKIIFLNWFVAGVMNFLNNFTAAQATISQAGAAAAESARQKAMDAYETATRMKLNIRIKA 1257
            :.:||::|::::.|...:::|||||.||:..:|.|...|||.|.....|..:.:.|:.::|.:||
Mouse  1695 LKVGCIQIVYVHKFFMSLLSFLNNFQAAKEALSTATVQAAERAASSVKDLAQKSFRLLMDIDLKA 1759

  Fly  1258 PIIIVPIGSQDRNALLLDLGLLELTNNTVEVAVAEEERLA---VIDEIKLQICDVKISKIVLLDG 1319
            |:|.:|..|...|.::.||||:.:.|....|:|   |:||   |.||:.:|:..:|:::.||
Mouse  1760 PVITIPQSSVSPNVVIADLGLIRVENKFSLVSV---EQLALPPVADEMSIQLTQLKLARTVL--- 1818

  Fly  1320 NESTVDEVDAEVGFLSKFNMMNPMSCTLSITRNLSYTWYRDVPELNLSGRLKSIELTLFADDYAL 1384
             ::...:.|.|:        :.|::..|.|.||||..||..:|.:.:.|.||.:::.|..||..:
Mouse  1819 -QADSPQHDVEI--------LKPVNMLLCIQRNLSAAWYTQIPGMEIKGELKPMQVALSQDDLTV 1874

  Fly  1385 VMLVLNRNLNEGLEEFPPSEEAPQEAQVRPERRNSRAG----RLSRTVQVSPIREKIHESIKFNF 1445
            :|.:|..||.|...:..|::.|.:.|:|   :|::|:|    :........|..::. .:::|:|
Mouse  1875 LMKILLENLGEASSQPSPTQYAQEAARV---KRDTRSGPDYLKEQELADPKPPGDQT-VTLQFDF 1935

  Fly  1446 QFDGVVINLMEGEGA------------GLARFGIYFLSVKGTKLDNGTLSTSVVLCNIQMDDMRS 1498
            .||.:.|.|...:.:            .|....::.::..|....:|:::.|:.|....:||:|.
Mouse  1936 HFDSLSIILYNSDSSQEPRLSFHNDSFRLGELTLHLMASAGKMFKDGSMNVSLKLKTCTLDDLRE 2000

  Fly  1499 NSKSQIRQYLSRKDWVQPKLDTD---EIIDACYNERNFMVDVTAIIKEDDTFAEVRVRGFDLIVC 1560
            ..:....:.:.:|:      |.|   .:||..|::......|.|::.:             |.||
Mouse  2001 GIERATSRMIDKKN------DQDNNSSMIDISYSQDKNGSQVDAVLDK-------------LYVC 2046

  Fly  1561 --IDFLLKLTTFLTLPPEENPRESVYIKPAPVSETARDTKHSIRSSAILAAQELVPVESSSHEVP 1623
              ::||:.:..|             :||..|  ::..:....|:..:...|...|.:|......|
Mouse  2047 ASVEFLMTVADF-------------FIKAMP--QSPENIAKEIQIPSRQTAAGRVKMEKDDSVRP 2096

  Fly  1624 NRKMNLILHIDEPDIILVENLEDLNTSCIIFNAQVHLNYRSINDKQIVNGQIDALKMYMCAFLPE 1688
            |  |.|...|.:|:::.|.:|...:...:..:.|.:|:..:...:|::...:..||:..|.||.|
Mouse  2097 N--MTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACPFLRE 2159

  Fly  1689 RREMTRHYILHPCVISLQGSTPEEEGMHISLKLSDIIINVSPATIELLNKAMLSVSSGTMTKCAI 1753
            ||..:...:|.||.:.::..|......:|::.:.:.:|.:||..:..:...|.::|..| .:...
Mouse  2160 RRGKSITTVLQPCSLFMEKCTWASGKQNINIVVKEFVIKISPIILNTVMTIMAAMSPKT-KEDEW 2223

  Fly  1754 AEESRNYSNLWHQHHFHSRTYWFTKVEQGVDALE----AEQRSVSTDNEKQKTEKCVIEIPSITL 1814
            .:..:...|||..........||..|:...:..|    :|..|:.        |.||:.:.|:.:
Mouse  2224 KDTPKETDNLWAVKSITDYNSWFLGVDMATEVTENFRDSEHPSIE--------ENCVVAVESVQV 2280

  Fly  1815 VIESGVGYYTKPLISLDTRITAVFNNWSRSLTAHGSLTLNMNYYNQALAEWEPIIELNEVIGRNG 1879
            .:|.|:|:.|.||:..:::.:....||:..:.|...:||.::|||:..|.|||:||  .|.|..
Mouse  2281 TLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAAADMTLEVHYYNETHAVWEPLIE--RVEGNK- 2342

  Fly  1880 VREYTPWELKFEMGMEKVQSEL---EDD---AEQQAMHMNIHSAETLEITLSKTCLGLLSELAEA 1938
                 ||.||..:....:|.:.   .||   ..|.|:|  |.|..|:.||:||:||.:.|.||:.
Mouse  2343 -----PWSLKLNVKKNPIQDKSLMPGDDFIPEPQTAVH--ISSGATMNITISKSCLNVFSNLAKG 2400

  Fly  1939 FSQAIDQNGLTKPDIVAPYVLENDTGFDVNLNLRKGIFTLHEVHRGGTP-------VGANSTLLM 1996
            ||:.............||:.::|..|..:.:...:.:..:      |:|       |||...|
Mouse  2401 FSEGAASTFDYSLKDRAPFTVKNALGVPMKVQPNRNLKVM------GSPEKSDIYDVGAGQHL-- 2457

  Fly  1997 VAQSEEVDPSVIKTCTISTGGRAYLQTKDLSTLSEEDSEDYTL-YVTIGDINKEIA-LPVSKSDT 2059
                 |:|.:.::.   |..|:       ||.||.::|..:|| :|..|  ..|:| :||::...
Mouse  2458 -----ELDYASLEP---SRQGK-------LSILSRQESSLFTLTFVPYG--YTEVASVPVARPGR 2505

  Fly  2060 RFFNLMRSTSHEPWGIISEVKQEYGTTKVNIHGVVSVHNHFTTGLNIYR--RNPAPTAQCFEDIF 2122
            |.:|:...::.....::.::....|...|.:...:.:.|||:....||:  :|    .:..|.|
Mouse  2506 RLYNVRNPSASHSDSVLVQIDATEGNKVVTLRSPLQIKNHFSIAFIIYKFVKN----VKLLERI- 2565

  Fly  2123 VGRVRPGEVFHVPLHAIYAESKDLFFSMRG-----YRRSVQGISWASNPSDLNYSHQLHC----- 2177
             |..||.|.|||||.:...:   |:....|     |..|...|||   ..:|:.|.::.|
Mouse  2566 -GIARPEEEFHVPLDSYRCQ---LYVQPAGGLEQQYTHSSTYISW---KEELHRSREVRCMLQCP 2623

  Fly  2178 DPTNTFEPLIMNARRSKSEVYFENTNKYTLLSAFYTIHLRPPLYLRNSLPINIQVSVAGCSVRKE 2242
            ....:|.|||:|......|:.:...:......| |.|||.|||.|||.||.:::..:.|.:...|
Mouse  2624 AVEVSFLPLIVNTVALPDELSYIGAHGEDWDPA-YVIHLYPPLTLRNLLPYSLRYLLEGTAETHE 2687

  Fly  2243 DGLDAQSSQRFVDRGYRKEDFLDYGEKPVNSGDVLHLPTVRLASKGKESKSFLVVRLVQYLEKDW 2307
                                 |..|    :|.||||         .:.|...:.:.||:||.|:|
Mouse  2688 ---------------------LAEG----SSADVLH---------SRISGEIIELVLVKYLGKNW 2718

  Fly  2308 SCATEIWDYTDDVITWTFSSYDSE-MKVDMDLYVKTENRHGSLM-LTLFSPFWMINKTGMMLTYK 2370
            :....|.|...:.....|||..:| |.||:.::|:   |.|..| |::|||:|:||||..:|.|:
Mouse  2719 NGHFRICDTLPEFFLVCFSSDTAEVMTVDLSVHVR---RIGCRMELSVFSPYWLINKTSRVLQYR 2780

  Fly  2371 SETTSVEVLYHPPEYSGPILFTFRDKLFFDKKKASIRIDNGQWSEKIPLDVAGSVGEVICFANNQ 2435
            ||...|:   ||.::...|||:|:.|..|.|.|..::|....||....||..||.|.|.|.|.|.
Mouse  2781 SEEIHVK---HPADFRDIILFSFKKKNIFSKNKVQLKISTSAWSNGFSLDTVGSYGCVKCPATNM 2842

  Fly  2436 KYPVGVHNHLTQNSLTKQITFIPFYIVCNKCHFDIELQE----QSRPADPWLHLEPNEMEPLWPR 2496
            :|.|||...::..:|::.:|..||..|.||...|:|:.|    .|.|.:.|.::..:|..|.||.
Mouse  2843 EYLVGVSIKMSSFNLSRVVTLTPFCTVANKSSLDLEVGEIASDGSIPTNKWHYVASSECIPFWPE 2907

  Fly  2497 NDTKNNLVVRV---DGKITPAFDFTEVICTLLKLEDSKYGGINVDVQTTEGGVYITFTDYKPADA 2558
            | ....|.|||   :|...|.|...:...|||.|||.. |||.||:.|.|....|||:||....|
Mouse  2908 N-LSGKLCVRVVGYEGSSKPFFYNRQDNGTLLSLEDLN-GGILVDINTAEHSTVITFSDYHEGSA 2970

  Fly  2559 PGLLINHTGKQIV-YHEKGTKNEHILNAKSTIMYAWDDPTGPKMLV--FGTNKEETDLKRDGIGE 2620
            |.|::|||...:: |.:.|::.|.:|....|.::||.||||.:.|.  :..|..|.||.:|..|:
Mouse  2971 PALIMNHTQWDVLTYKQSGSQEELVLLPGETRLFAWADPTGIRKLTWNYAANFGEHDLLKDECGQ 3035

  Fly  2621 VIMQDGGKVLWVSFLDGLQRVLLFTENESIANRTESTASLQSITQSIDLRIHGIGLSVINNETGL 2685
            .......::.|||||||.|||||||::.::.::......::.....:.|.:|.:|||::|||...
Mouse  3036 FPYDANIQIHWVSFLDGRQRVLLFTDDVALVSKALQAEEMEQADHEVALSLHSLGLSLVNNENKQ 3100

  Fly  2686 DILYLGVTSSGIIWESKKVTKNRFKELTINENALLEIEYQKYLVHKSVNDVQTYKLDNKFPIDFD 2750
            ::.|:|:||||::||.|  .|.::|..:..:...||..|.|.|..:   |....|||:.|.::||
Mouse  3101 EVSYVGITSSGVVWEMK--PKQKWKPFSQKQIMSLEQAYSKRLASQ---DRGWVKLDSNFEVNFD 3160

  Fly  2751 L--MILKKTVERNLRRSFYPAIWLSRKSSPFQSQLHVKINRIQVDNQFLDPIFPVVLAPIPPPKS 2813
            .  |.::..:...::|.|...|.:..|.||.|..|..::..:|||||....:||||..|:.||||
Mouse  3161 KVPMEMRLPIRCPIKRDFLSGIQVEFKQSPHQRSLRARLYWLQVDNQLPGTMFPVVFHPVAPPKS 3225

  Fly  2814 VASTTSLKPFIECSMVQRIMPNSTVRQFKYARILIQEFLFKVDLNFLTAIAEMFAKEVSDEAAAK 2878
            :|..:..||||:.|::.|....|.|.||||..:||||...|||..||.|:..:|......||..|
Mouse  3226 IALDSEPKPFIDVSVITRFNEYSKVLQFKYFMVLIQEMALKVDQGFLGAVISLFTPTTDPEAERK 3290

  Fly  2879 Q---FRQDVESIELPLSAFFEEHSLEEQK--SFYDNLHLGPLKIHVSFSMAG----SDTK----- 2929
            :   .:||::::...|.    |.|:.:..  ||:::.|:.|:|:|:|.|:..    ||.:
Mouse  3291 RTKLIQQDIDALNTELM----ESSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMI 3351

  Fly  2930 ALPGFLGSLVQGVGVTLTDVNDVVFRLAFFEREYQFFSQKQLINEITSHYTGQALKQLYVLVLGL 2994
            |:.. :..|::.:|.|||||:|::|:||::|..|||:.:.||:..:..||:.|.|||:|||||||
Mouse  3352 AIHS-VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLMWSVVRHYSEQFLKQMYVLVLGL 3415

  Fly  2995 DVLGNPYGLVVGLKKGVEDLFYEPFQGAIQGPGEFAEGLVLGVKSLFGHTVGGAAGAVSKITGAM 3059
            ||||||:||:.||.:|||.|||||||||:|||.|||||||:||:||.|||||||||.||:|||::
Mouse  3416 DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLVGHTVGGAAGVVSRITGSV 3480

  Fly  3060 GKGLAALTFDEDYQKKRRQGIQNKPKNFHEGLARSSKGLVMGFVDGVTGVVTKPVTGARDNGVEG 3124
            ||||||:|.|::||:|||:.:..:||:|.:.|||..||.:.|.|.||||::||||.||:..|..|
Mouse  3481 GKGLAAITMDKEYQQKRREEMGRQPKDFGDSLARGGKGFLRGVVGGVTGIITKPVEGAKKEGAAG 3545

  Fly  3125 FFKGLGKGAIGLVARPTAGVVDFASGSFEAVKRAADASEDVKRMRPPRFQHYDFVLRPYCLMEAT 3189
            ||||:|||.:|.|||||.|::|.||.:|:.::|.|:::|:|..:||||..|.|.::|||...|:.
Mouse  3546 FFKGIGKGLVGAVARPTGGIIDMASSTFQGIQRVAESTEEVSSLRPPRLIHEDGIIRPYDRQESE 3610

  Fly  3190 GNKIMKETDKGKFATTDNFIHCEEIIQKSEYLVVTNYRVMYVQRNEMFGVWTSLWSYLWNE-ISS 3253
            |:.:::...|........| ||.....|...|::||.|.::::..|:.|..:..|..|:.: :..
Mouse  3611 GSDLLENHIKKLEGEAYQF-HCAVPGNKRAVLMITNRRALFIKEVEILGHMSVDWQCLFEDFVCP 3674

  Fly  3254 VAATARGVQFTVKTDGKKVLGLFSSKESP-----RKLVL---VADERKRDALVDIIESQRS 3306
            ...:...::.:||..     |||..|:|.     ||:.|   :..:|..||    |||.:|
Mouse  3675 PEVSENLLKISVKEQ-----GLFHKKDSANIGHLRKIYLKDPITAKRAFDA----IESAQS 3726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13	NP_001260781.1	Chorein_N	4..113	CDD:315323	62/108 (57%)
		VPS13	140..370	CDD:318996	79/237 (33%)
		VPS13_mid_rpt	574..807	CDD:318998	74/232 (32%)
		SHR-BD	2349..2600	CDD:310922	101/259 (39%)
		VPS13	<2701..3232	CDD:330393	238/546 (44%)
		VPS13_C	2904..3074	CDD:318997	100/180 (56%)
Vps13c	NP_796158.2	Chorein_N	4..113	CDD:289396	62/108 (57%)
		VPS13	185..414	CDD:293513	79/237 (33%)
		VPS13_mid_rpt	612..832	CDD:293515	73/231 (32%)
		VPS13_mid_rpt	<1236..1366	CDD:293515	6/129 (5%)
		MRS6	<1237..>2607	CDD:227376	327/1505 (22%)
		VPS13_mid_rpt	1687..1879	CDD:293515	63/206 (31%)
		SHR-BD	2759..3013	CDD:284143	101/258 (39%)
		WWE	3111..>3161	CDD:295449	17/54 (31%)
		VPS13_C	3318..3495	CDD:293514	100/177 (56%)
		ATG_C	3503..3577	CDD:286423	40/73 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839842
Domainoid	1	1.000	216	1.000	Domainoid score	I2694
eggNOG	1	0.900	-	-		E1_COG5043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54975
OrthoDB	1	1.010	-	-		D4159at2759
OrthoFinder	1	1.000	-	-		FOG0001282
OrthoInspector	1	1.000	-	-		otm43387
orthoMCL	1	0.900	-	-		OOG6_101020
Panther	1	1.100	-	-	LDO	PTHR16166
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	1	1.000	-	-		X990
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.750