DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps13 and VPS13B

DIOPT Version :9

Sequence 1:	NP_001260781.1	Gene:	Vps13 / 35693	FlyBaseID:	FBgn0033194	Length:	3321	Species:	Drosophila melanogaster
Sequence 2:	NP_060360.3	Gene:	VPS13B / 157680	HGNCID:	2183	Length:	4022	Species:	Homo sapiens

Alignment Length:	4288	Identity:	757/4288 - (17%)
Similarity:	1354/4288 - (31%)	Gaps:	1554/4288 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VFEAVVADVLNKVLGDYIENLDRNQLKIGIWGGDVVLQNLKIRENALD-ELDLPVQLIYGYLGKL 65
            :.|:.|..:|...:..||:||..:.|::.:|||||||..|:::.:.|: ||.||...:.|::.:|
Human     1 MLESYVTPILMSYVNRYIKNLKPSDLQLSLWGGDVVLSKLELKLDVLEQELKLPFTFLSGHIHEL 65

  Fly    66 VLKIPWKNLYSQPVIVNIEDLYVLVSPNNNVQYNAEK--EAKYEMDLKKAALDALEAARKKELEM 128
            .:.:||..|.|:||::.|..:..::...:.:|.:.|.  .........::...:::..|.::...
Human    66 RIHVPWTKLGSEPVVITINTMECILKLKDGIQDDHESCGSNSTNRSTAESTKSSIKPRRMQQAAP 130

  Fly   129 DQPKADAGFAEKLTAQIVNNLQVQITNVHLRY-EDTTTTGSPFSFGISLHELELYTTDCDWEKCY 192
            ..|....|:.:.|..::|||:.:.|.|:.|:| ||...      ..:::...|.||....|::.:
Human   131 TDPDLPPGYVQSLIRRVVNNVNIVINNLILKYVEDDIV------LSVNITSAECYTVGELWDRAF 189

  Fly   193 MAQQASQVF--KIANLSCLSAYLNCGGQLYANNKSDLSQQFKTNIACK---ETKPNYNYVLGPIS 252
            |...|:.:.  |:.|.|      :|...|...|.|...:.::..:..|   .|:.::.|.
Human   190 MDISATDLVLRKVINFS------DCTVCLDKRNASGKIEFYQDPLLYKCSFRTRLHFTYE----- 243

  Fly   253 CNAKLKLNMNPELDDPPFEKPKIDLTLEMEKLNVGLTNTQ---FDNLMKLGDAM----------- 303
                   |:|.::..      .|.:...:|.|.:.:|:.|   |..:|:||.|:
Human   244 -------NLNSKMPS------VIKIHTLVESLKLSITDQQLPMFIRIMQLGIALYYGEIGNFKEG 295

  Fly   304 --------NRQQLG------IPYRKYRPYNIPYKGHARDWWHFAITSILEEEVRKPRESWTWGHI 354
                    |:..||      ...|....|...:||.       .:.|..:||..:...||.|..:
Human   296 EIEDLTCHNKDMLGNITGSEDETRIDMQYPAQHKGQ-------ELYSQQDEEQPQGWVSWAWSFV 353

  Fly   355 K------------THRERCNTYAQKYKEQCLSKKPSAVL-------TETCRLLETELDVFNLLLI 400
            .            ...:..:|..|: |.|.| |.|...:       |.|.:|  ||:.|.:....
Human   354 PAIVSYDDGEEDFVGNDPASTMHQQ-KAQTL-KDPIVSIGFYCTKATVTFKL--TEMQVESSYYS 414

  Fly   401 RQRVNIEIAKQREAVPEQKSGWFSGWGWGGGAKKDDQTTSQKL---------------------- 443
            .|:|     |.:|.:..::.|                ||.:.|
Human   415 PQKV-----KSKEVLCWEQEG----------------TTVEALMMGEPFFDCQIGFVGCRAMCLK 458

  Fly   444 ----VEKFEAAMTSEEKEKMYRAIGYQENAKPTDLPESYEAIRMNFKLIALEVGLYKDERNSSAA 504
                |:.||..|...|.|..:...|...:.|             .|..:...:..|:...|
Human   459 GIMGVKDFEENMNRSETEACFFICGDNLSTK-------------GFTYLTNSLFDYRSPEN---- 506

  Fly   505 TKDFHELPSLVLLNFSMATALITQRPAAEAISIIAGMREIKVTGLTRNDYTPLLVESKITDEFNL 569
                         |.:.|..::......|..:.||||:..   |....||  |......:.:.:.
Human   507 -------------NGTRAEFILDSTHHKETYTEIAGMQRF---GAFYMDY--LYTMENTSGKGST 553

  Fly   570 LEVFFETNPLDKLCDQRVK----VVARPLQITYDAPTILALINAFQTPGDVTLSKFEDAASTKIS 630
            .:..|.:...:.|...:.|    :|..||....|:..:..::.......:   .::|..:..| |
Human   554 NQQDFSSGKSEDLGTVQEKSTKSLVIGPLDFRLDSSAVHRILKMIVCALE---HEYEPYSRLK-S 614

  Fly   631 NFKERSATGMQYMIDKKAVLD-VDILLMPNILVVPHKGVYDAGNVSLL----VVSMGQVHLSSQP 690
            :.|:.:.|          :|: .::.|:...:...|.      :|:||    .:||.
Human   615 DIKDENET----------ILNPEEVALLEEYIPTRHT------SVTLLKCTCTISMA-------- 655

  Fly   691 RRESNKLQHLFSA--GE-DKDEILKTVMENA---YDRFTVAVDDVQM-------------LVVRA 736
              |.|.|.||...  || :....:.|....:   .....:.||.:.:             :|...
Human   656 --EFNLLDHLLPVIMGEKNSSNFMNTTNFQSLRPLPSIRILVDKINLEHSVPMYAEQLVHVVSSL 718

  Fly   737 GEPWQNAL-------------AEANSTEMHVLRPVSLKV-----------------------TAA 765
            .:|..|.|             .:|..|.:.......|.|                       .:.
Human   719 TQPSDNLLHYCYVHCYLKIFGFQAGLTSLDCSGSYCLPVPVIPSFSTALYGKLLKLPTCWTKRSQ 783

  Fly   766 LCVVDNDPRLPNIKVD------IDLPAI------LVNVSE--------DRIFLAIKVATSIPLP- 809
            :.:.:....|||:.:.      :.|.||      |.|||.        :.|||:|.|.:..|||
Human   784 IAITEGIFELPNLTIQATRAQTLLLQAIYQSWSHLGNVSSSAVIEALINEIFLSIGVKSKNPLPT 848

  Fly   810 --------EQKEPASRLTQTNSRSSMSISNFINKEV----KKIGPSASGSSASKD---------- 852
                    |.|..::.|.:..|.:..||.......|    :|:.|...|.|.:||
Human   849 LEGSIQNVELKYCSTSLVKCASGTMGSIKICAKAPVDSGKEKLIPLLQGPSDTKDLHSTKWLNES 913

  Fly   853 --P---LLDEIIQYT----------------------SLDVNFSLGEINFVLFQ----SSRKCET 886
              |   |..:::.:|                      .|.||.......::::|    :||..:.
Human   914 RKPESLLAPDLMAFTIQVPQYIDYCHNSGAVLLCSIQGLAVNIDPILYTWLIYQPQKRTSRHMQQ 978

  Fly   887 SPDVSIEFLTP------DGDVLPS---------QLTENIQEPI------EELPPTPPQQ------ 924
            .|.|::..:.|      |...:.|         |.:|....|:      |..|.:.|.:
Human   979 QPVVAVPLVMPVCRRKEDEVSIGSAPLAKQQSYQASEYASSPVKTKTVTESRPLSVPVKAMLNIS 1043

  Fly   925 ------------------------ILSIDIRRLEAHFVSKTYESVATVKLGDI--NLRQYDCQDS 963
                                    .|.::::.......:.:..|.:|:..|||  .:|.:....:
Human  1044 ESCRSPEERMKEFIGIVWNAVKHLTLQLEVQSCCVFIPNDSLPSPSTIVSGDIPGTVRSWYHGQT 1108

  Fly   964 DM-------------------------DVLDVIYTPKQENSSNYLFTVS---------------- 987
            .|                         ::..||..|..|....:.:|:|
Human  1109 SMPGTLVLCLPQIKIISAGHKYMEPLQEIPFVIPRPILEEGDAFPWTISLHNFSIYTLLGKQVTL 1173

  Fly   988 -------C--TIADKSSPEFSTKYNSTEQLVV---ANFEVL-------QIVLHQECLQRIMEVVN 1033
                   |  |:|..|....:|..::....||   .:.|.|       |:.|..|....:.:|.|
Human  1174 CLVEPMGCTSTLAVTSQKLLATGPDTRHSFVVCLHVDLESLEIKCSNPQVQLFYELTDIMNKVWN 1238

  Fly  1034 NFQRNLDLVLSSTRPRDRMGSIGGGDGIKRTLNVILEDTE------EIMTTDQMKRRKKTRRTHV 1092
            ..|:..:|.||.|.|....|.:.... ::.::.....||.      :|.||.:....:....:..
Human  1239 KIQKRGNLNLSPTSPETMAGPVPTSP-VRSSIGTAPPDTSTCSPSADIGTTTEGDSIQAGEESPF 1302

  Fly  1093 VETVKV-RVIANLDQV-GLVLTGRKRPIAEMNVKKFVSSLIIKSSYTEVNIGLKDIQVLDLNPYT 1155
            .::|.: :..:|:... |.|....:..:.::.:|.|...        ..|.|.:...|.:|...:
Human  1303 SDSVTLEQTTSNIGGTSGRVSLWMQWVLPKITIKLFAPD--------PENKGTEVCMVSELEDLS 1359

  Fly  1156 IHKNILSIVGKDAFNCQIVIYNKEETQDYNSDDMKITVDIGCMKIIFLNWFVAGVMNFLNNFTAA 1220
            ...::..:..|  ..|:|        :.:|.|..:.::...|       |
Human  1360 ASIDVQDVYTK--VKCKI--------ESFNIDHYRSSLGEEC-------W--------------- 1392

  Fly  1221 QATISQAGAAAAESARQKAMDAYETATRMKLNIRIKAPIIIVPIGSQD-----------RNALLL 1274
              ::.|.|.            .:.:.|. |||.|   .:::.||..||           ....||
Human  1393 --SLGQCGG------------VFLSCTD-KLNRR---TLLVRPISKQDPFSNCSGFFPSTTTKLL 1439

  Fly  1275 D-----LGLLEL------TNNTVEVAVAEEERLAVIDEIKLQICDVKISKIVLLDGNESTVDEV- 1327
            |     .|.|.|      |.|......:..||.:.          .|:|: .|:||:...:.|:
Human  1440 DGTHQQHGFLSLTYTKAVTKNVRHKLTSRNERRSF----------HKLSE-GLMDGSPHFLHEIL 1493

  Fly  1328 -DAEV-GFLSKFNMMNPMSCTLSITRNLSYTWYRDVPELNL-SGRLKSIELTLFADDYALVMLVL 1389
             .|:. ..:..|.::|.::.........:....|..|...: :..|.|..|.|...:.:::.:.:
Human  1494 LSAQAFDIVLYFPLLNAIASIFQAKLPKTQKEKRKSPGQPMRTHTLTSRNLPLIYVNTSVIRIFI 1558

  Fly  1390 NRNLNEGLEEFPPSEEAPQEAQ------------VRPERRNS------RAGRLSRTVQVSPIREK 1436
            .:.     ||..|:.||.|.|:            :.|:..|.      |.....|.:.:..:|:.
Human  1559 PKT-----EEMQPTVEANQAAKEDTVVLKIGSVAMAPQADNPLGRSVLRKDIYQRALNLGILRDP 1618

  Fly  1437 IHESIKFNFQFDGVVINLMEGEGAGLARFGIYFLSVKGTKLDNGTLSTSVVLCNIQMDDMRSNSK 1501
            ..|.....:|.|...||:      |.|::  :.|..:...:..|.::.:.  .|.|...:..|..
Human  1619 GSEIEDRQYQIDLQSINI------GTAQW--HQLKPEKESVSGGVVTETE--RNSQNPALEWNMA 1673

  Fly  1502 SQIRQYLSRKDWVQPKLDTDEIIDACYNERNFMVDVTA--------IIKEDDTFAEVRVRGFDLI 1558
            |.||::..|:..:.|.| ||           |.|.:|.        ::..::...|      :::
Human  1674 SSIRRHQERRAILTPVL-TD-----------FSVRITGAPAVIFTKVVSPENLHTE------EIL 1720

  Fly  1559 VC-----------IDFLLK-----------LTTFLTLPPEENPRE-------------------- 1581
            ||           :||.|.           :.....|.|.....|
Human  1721 VCGHSLEVNITTNLDFFLSVAQVQLLHQLIVANMTGLEPSNKAAEISKQEQKKVDIFDGGMAETS 1785

  Fly  1582 --------------SVYIKPAPVSETARDTKHSI----RSSAILAAQELVPVE------------ 1616
                          ||.|:...:.:.:..::|.|    |.|:|:.....:|.:
Human  1786 SRYSGAQDSGIGSDSVKIRIVQIEQHSGASQHRIARPSRQSSIVKNLNFIPFDIFITASRISLMT 1850

  Fly  1617 --------SSSHEVPNR----KMNLILHIDEPDI-------ILVENLEDLNTSCIIFNA------ 1656
                    |.|.|..|.    |.:|.|...:.|:       |.....|||..|.|.|.:
Human  1851 YSCMALSKSKSQEQKNNEKTDKSSLNLPEVDSDVAKPNQACISTVTAEDLLRSSISFPSGKKIGV 1915

  Fly  1657 ----QVHLNYRSI-----------------------------------------NDKQIVNGQI- 1675
                .:|.:.||.                                         :.||.|...|
Human  1916 LSLESLHASTRSSARQALGITIVRQPGRRGTGDLQLEPFLYFIVSQPSLLLSCHHRKQRVEVSIF 1980

  Fly  1676 DAL-----KMYMC----AFLPERREMTRHYILHPCVISLQ---GSTPEEEGM---HISLKLSDII 1725
            ||:     ..|.|    ..|||        .|..|.:.||   |....:.|:   .|:|::.|.:
Human  1981 DAVLKGVASDYKCIDPGKTLPE--------ALDYCTVWLQTVPGEIDSKSGIPPSFITLQIKDFL 2037

  Fly  1726 ---------------INVSPATIELLNKAMLSVSSGTMTKCAIAEESRNYSN-LWHQHHFHSRTY 1774
                           .|:|...::.:|..:..:.:.  ...|.:||:...|| :.::.......|
Human  2038 NGPADVNLDISKPLKANLSFTKLDQINLFLKKIKNA--HSLAHSEETSAMSNTMVNKDDLPVSKY 2100

  Fly  1775 WFTKVEQ------GVDALEAEQ---RSVSTDNEKQKTEKCVIEIPSITLVIESGVGYYTKPLISL 1830
            :..|:.:      ||..:.|::   |:||.      .:|..::...|.:.:|: |.:.:||.
Human  2101 YRGKLSKPKIHGDGVQKISAQENMWRAVSC------FQKISVQTTQIVISMET-VPHTSKPC--- 2155

  Fly  1831 DTRITAVFNNWSRSLTAHGS-----LTLNMNYYNQALAEWEPIIELNEVIGRNGVREYT------ 1884
               :.|..:|.:.||:...:     :.|..::          ::.:|:.:.:..::|.:
Human  2156 ---LLASLSNLNGSLSVKATQKVPGIILGSSF----------LLSINDFLLKTSLKERSRILIGP 2207

  Fly  1885 -----PWELKF---------EMGMEKVQSELEDDAEQ---QAMHMNIHSAETLEITLSKTCLGLL 1932
                 ..|.|:         |..:.|:..:|.....|   ...|:|              ||.||
Human  2208 CCATANLEAKWCKHSGNPGPEQSIPKISIDLRGGLLQVFWGQEHLN--------------CLVLL 2258

  Fly  1933 SELAEAFSQAIDQNGLTKPDIVAPYVLENDTGFDVNLNLRKGIFTLHEVHRGGTPVGANSTLLMV 1997
            .||...:                   |..:..|:|.::        ..|.:..:||..|.|....
Human  2259 HELLNGY-------------------LNEEGNFEVQVS--------EPVPQMSSPVEKNQTFKSE 2296

  Fly  1998 AQSEEVDPSVIKTCTISTGGRAYLQTKDLSTLSEEDSEDYTLYVTIGDINKEIALPVSKSDTRFF 2062
            ..|::          :.||...|:|          |:|             .:.|| ...:..|:
Human  2297 QSSDD----------LRTGLFQYVQ----------DAE-------------SLKLP-GVYEVLFY 2327

  Fly  2063 NLMRSTSHEP----WGIISEVKQEYGTTKVNIHGVVSVHNHFTTGLNIYRRNPAPTAQCFEDIFV 2123
            |   .|...|    |        .|...:|               |.:.|..|.| ....||..:
Human  2328 N---ETEDCPGMMLW--------RYPEPRV---------------LTLVRITPVP-FNTTEDPDI 2365

  Fly  2124 GRVRPGEVFHVPLHAIY-AESKDLFFSMRGYRRSVQGISWASNP-------------SD-----L 2169
            .....|:|..||....| .|.:.:|.:.|.:..|...:.....|             ||     |
Human  2366 STADLGDVLQVPCSLEYWDELQKVFVAFREFNLSESKVCELQLPDINLVNDQKKLVSSDLWRIVL 2430

  Fly  2170 NYSH--------------QLHCDPTNTFEPLIMNARRSKSEVYFENTNKYTLLSAFYTIHLR--- 2217
            |.|.              |..|||..|...|   |..::.:..|......:|..:|...||.
Human  2431 NSSQNGADDQSSASESGSQSTCDPLVTPTAL---AACTRVDSCFTPWFVPSLCVSFQFAHLEFHL 2492

  Fly  2218 ----------PPLYLR-----NSLPINIQVSVAGC-------------SVRKEDGLDAQSSQRFV 2254
                      .|.||:     .::|..::..:...             ||.:|....||:..:.:
Human  2493 CHHLDQLGTAAPQYLQPFVSDRNMPSELEYMIVSFREPHMYLRQWNNGSVCQEIQFLAQADCKLL 2557

  Fly  2255 D-RGYRKED----FLDYGEKPVNSGDVLHL--PTVRLASKGKESKSFLVVRLVQYLEKDWSCATE 2312
            : |....:.    |..:|:..|:|..|..|  .||.:.|        :.|.|.|::....:.|.:
Human  2558 ECRNVTMQSVVKPFSIFGQMAVSSDVVEKLLDCTVIVDS--------VFVNLGQHVVHSLNTAIQ 2614

  Fly  2313 IWDYTDDVITWTFSSYDSEMKVDMDLYVKTENRHGSLMLTLFSPFWMINKTGMMLTYKSETTSVE 2377
            .|.                           :|:...:...:||.|.:.|.|...|.:....|...
Human  2615 AWQ---------------------------QNKCPEVEELVFSHFVICNDTQETLRFGQVDTDEN 2652

  Fly  2378 VL---YHPPEYSGPILFTFRDKLFFDKKKASIRI-----DNGQWSEKIPLDVAGSVGEVICFANN 2434
            :|   .|..:||      :|.    .|....:.|     .|.:|||...:|.||:....|.:...
Human  2653 ILLASLHSHQYS------WRS----HKSPQLLHICIEGWGNWRWSEPFSVDHAGTFIRTIQYRGR 2707

  Fly  2435 QKYPVGVHNHLTQNSLTKQITFIPFYIVCN-----------------------KCHFDIELQEQS 2476
            ....:.....|  |.:.|||......|:|:                       :.|||....:|.
Human  2708 TASLIIKVQQL--NGVQKQIIICGRQIICSYLSQSIELKVVQHYIGQDGQAVVREHFDCLTAKQK 2770

  Fly  2477 RPADPWLHLEPNEMEPL---------WPRN---DTK---NNLVVRVDGKITPAFDFTEVICTLLK 2526
            .|:   ..||.||:..|         |.|:   ::|   .::|::|....:   ....|.||:|.
Human  2771 LPS---YILENNELTELCVKAKGDEDWSRDVCLESKAPEYSIVIQVPSSNS---SIIYVWCTVLT 2829

  Fly  2527 LEDSKY-----------------------------------------GGINVDVQTTEGGV--YI 2548
            ||.:..                                         .|....:|..|..:  ::
Human  2830 LEPNSQVQQRMIVFSPLFIMRSHLPDPIIIHLEKRSLGLSETQIIPGKGQEKPLQNIEPDLVHHL 2894

  Fly  2549 TF---TDYKPADAPGLLINHTGKQIV--YHEKGTKNEHILNA--------------------KST 2588
            ||   .:|.|:|....:.....|||.  .|..||.|: ||:.                    ::.
Human  2895 TFQAREEYDPSDCAVPISTSLIKQIATKVHPGGTVNQ-ILDEFYGPEKSLQPIWPYNKKDSDRNE 2958

  Fly  2589 IMYAWDDPTGPKMLVFG----------------TNKEETDL-KRDGIGEVIMQDGGKVLW-VSFL 2635
            .:..||.|...|:.::.                .|:.:.|| ..:|...|:....||::. .:|.
Human  2959 QLSQWDSPMRVKLSIWKPYVRTLLIELLPWALLINESKWDLWLFEGEKIVLQVPAGKIIIPPNFQ 3023

  Fly  2636 DGLQRVLLFTENESIANRTESTASLQSITQSIDLRIHGIG-LSVINNETGLDI-LYLGV------ 2692
            :..| :.::..|.:..:::.:...:.::| |...:..|.| :..::.|..:|. :.||.
Human  3024 EAFQ-IGIYWANTNTVHKSVAIKLVHNLT-SPKWKDGGNGEVVTLDEEAFVDTEIRLGAFPGHQK 3086

  Fly  2693 ----TSSGIIWESKKVTKNRFKELTINENALLEIEYQKYL----VHKS-----VNDVQTYKL--- 2741
                ..|.::.:..::.:...|...|| |...:|.|:..|    .|..     |.|..|:.:
Human  3087 LCQFCISSMVQQGIQIIQIEDKTTIIN-NTPYQIFYKPQLSVCNPHSGKEYFRVPDSATFSICPG 3150

  Fly  2742 -------DNKFPIDFDLM------ILKKT-VERNLRRSFYPA-------IW----LSRKSSPFQS 2781
                   .:..|. :|||      :|..: :::.:...|.||       .|    :.|...|.||
Human  3151 GEQPAMKSSSLPC-WDLMPDISQSVLDASLLQKQIMLGFSPAPGADSSQCWSLPAIVRPEFPRQS 3214

  Fly  2782 ----------------------QLHVKIN----------RIQVDNQ----------FLD-PIFPV 2803
                                  |.|:.:.          |:.:.|:          ..| |.|.|
Human  3215 VAVPLGNFRENGFCTRAIVLTYQEHLGVTYLTLSEDPSPRVIIHNRCPVKMLIKENIKDIPKFEV 3279

  Fly  2804 VLAPIPPPKSV-------------ASTTSLKPFIECSMVQRIMPNSTVRQFKYARILIQEFLFKV 2855
            ....||...|:             ..|..|.|    |::.|:.|...|         ..|:...:
Human  3280 YCKKIPSECSIHHELYHQISSYPDCKTKDLLP----SLLLRVEPLDEV---------TTEWSDAI 3331

  Fly  2856 DLN-------FLTAIA----------------------------------------EMFAKEVS- 2872
            |:|       |||...                                        :||..::|
Human  3332 DINSQGTQVVFLTGFGYVYVDVVHQCGTVFITVAPEGKAGPILTNTNRAPEKIVTFKMFITQLSL 3396

  Fly  2873 --------DEAAAKQFRQDVESI-------------ELPLSAFFEEHSLE--------------- 2901
                    .:|:|:..|..:::|             |.|::|.||.:.:|
Human  3397 AVFDDLTHHKASAELLRLTLDNIFLCVAPGAGPLPGEEPVAALFELYCVEICCGDLQLDNQLYNK 3461

  Fly  2902 ------------------------------------EQKSFYD------------------NLHL 2912
                                                ::|.|..                  :..|
Human  3462 SNFHFAVLVCQGEKAEPIQCSKMQSLLISNKELEEYKEKCFIKLCITLNEGKSILCDINEFSFEL 3526

  Fly  2913 GPLKIHV-----------------SFSMAGSDTKALPGFLGSLVQGVGVT---LTDVNDVVFR-- 2955
            .|.:::|                 :..:||..|. |.|  |..|..:.||   ...||.|..|
Human  3527 KPARLYVEDTFVYYIKTLFDTYLPNSRLAGHSTH-LSG--GKQVLPMQVTQHARALVNPVKLRKL 3588

  Fly  2956 -------------------------LAF--FEREYQFFSQKQLINEITSHYTGQALKQLYVLVLG 2993
                                     |:|  |||...|.:.:||::.:..||...||.:...:|..
Human  3589 VIQPVNLLVSIHASLKLYIASDHTPLSFSVFERGPIFTTARQLVHALAMHYAAGALFRAGWVVGS 3653

  Fly  2994 LDVLGNPYGLVVGLKKGVEDLFYEPFQGAIQGPGEFAEGLVLGVKSLFGHTVGGAAGAVSKITGA 3058
            ||:||:|..||..:..||.|.|..|::|..:|||.|..|:..|..|...|...|...:::.:..:
Human  3654 LDILGSPASLVRSIGNGVADFFRLPYEGLTRGPGAFVSGVSRGTTSFVKHISKGTLTSITNLATS 3718

  Fly  3059 MGKGLAALTFDEDYQKKRRQGIQNKPKNFHEGLARSSKGLVMGFVDGVTGVVTKPV--------- 3114
            :.:.:..|:.||::..::.:..:..|::..|||.:....|.:..:..:.|:|.:|:
Human  3719 LARNMDRLSLDEEHYNRQEEWRRQLPESLGEGLRQGLSRLGISLLGAIAGIVDQPMQNFQKTSEA 3783

  Fly  3115 TGARDNGVEGFFKGLGKGAIGLVARPTAGVVDFASGSFEAVKRAADASEDVKRMRPPRFQHYD 3177
            ..:..:..:|...|:|||.:|:..:|..|..:..|.:...:...|..|:..|:...|...|.|
Human  3784 QASAGHKAKGVISGVGKGIMGVFTKPIGGAAELVSQTGYGILHGAGLSQLPKQRHQPSDLHAD 3846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps13	NP_001260781.1	Chorein_N	4..113	CDD:315323	32/111 (29%)
		VPS13	140..370	CDD:318996	53/275 (19%)
		VPS13_mid_rpt	574..807	CDD:318998	53/316 (17%)
		SHR-BD	2349..2600	CDD:310922	70/364 (19%)
		VPS13	<2701..3232	CDD:330393	140/766 (18%)
		VPS13_C	2904..3074	CDD:318997	56/236 (24%)
VPS13B	NP_060360.3	Chorein_N	3..94	CDD:289396	30/90 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..134		2/33 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1247..1314		11/67 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1880		6/19 (32%)
		SHR-BD	<2632..>2712	CDD:284143	20/89 (22%)
		VPS13_C	3585..3731	CDD:293514	38/145 (26%)
		ATG_C	3733..3839	CDD:286423	20/105 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5043
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1642
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930