Protein Alignment Corin and TMPRSS11D

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_004253.1
• Gene: TMPRSS11D / 9407
• HGNCID: 24059
• Length: 418
• Species: Homo sapiens
• Alignment Length: 304
• Identity: 108/304 - (35%)
• Similarity: 159/304 - (52%)
• Gaps: 33/304 - (10%)

  Fly  1057 MYAKRKSTLMQEFANCKKTEDYPMADLT------CSNY---ECGRVKRGRHKPSRRIIGGTQASP 1112
            |.::.:|.|.|...|....|..|..::|      .:|:   |||..........:||:|||:|..
Human   131 MKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEE 195

  Fly  1113 GNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQK 1177
            |:||:..::  ......:|.|.||::.|:|||:||..:.|  :..||....|:    |.|:...:
Human   196 GSWPWQVSL--RLNNAHHCGGSLINNMWILTAAHCFRSNS--NPRDWIATSGI----STTFPKLR 252

  Fly  1178 VKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKRE 1242
            ::|:.::.|..|..| .|:|||||.:|...|.|.:.:..||| |.:.:|:.||:...|.|||.:|
Human   253 MRVRNILIHNNYKSA-THENDIALVRLENSVTFTKDIHSVCL-PAATQNIPPGSTAYVTGWGAQE 315

  Fly  1243 DKDPKSTYE-YIVNEV---QVPIITRNQCD-EWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLL 1302
                   |. :.|.|:   ||.||:.:.|: ....|..:..||:|||...||.|||||||||||:
Human   316 -------YAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLV 373

  Fly  1303 CPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQ 1346
              ....:..||:.||||||..|..|..||||..|..|:.||::|
Human   374 --QEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQ 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	94/246 (38%)
TMPRSS11D	NP_004253.1	SEA	48..146	CDD:460188	4/14 (29%)
		Tryp_SPc	187..415	CDD:238113	94/246 (38%)