DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Corin and FZD8

DIOPT Version :10

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_114072.1 Gene:FZD8 / 8325 HGNCID:4046 Length:694 Species:Homo sapiens


Alignment Length:183 Identity:47/183 - (25%)
Similarity:76/183 - (41%) Gaps:33/183 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   728 LINAFALLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQI 792
            |:.|.|||..:.|.||                         :..|..|   |..|.|..|:|  |
Human    12 LLAALALLQRSSGAAA-------------------------ASAKELA---CQEITVPLCKG--I 46

  Fly   793 PYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQS-GATVPPCKTLC 856
            .||||..||...|..|.|...::..:..||:::|...:..|||:::.|.|.:. ...:|||:::|
Human    47 GYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVC 111

  Fly   857 TETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVR-EVMRAATHP 908
            ......|......:|.:.|:.:.|....: ..:.|.:.:|..| ::..||..|
Human   112 ERAKAGCAPLMRQYGFAWPDRMRCDRLPE-QGNPDTLCMDYNRTDLTTAAPSP 163

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 32/116 (28%)
LDLa 911..942 CDD:238060
LDLa 945..979 CDD:238060
SR 980..>1034 CDD:214555
Tryp_SPc 1104..1346 CDD:238113
FZD8NP_114072.1 CRD_FZ8 31..155 CDD:143570 36/129 (28%)
Wnt-binding. /evidence=ECO:0000250 95..100 1/4 (25%)
Wnt-binding. /evidence=ECO:0000250 147..152 1/4 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..226 3/9 (33%)
7tmF_FZD8 267..618 CDD:320378
TM helix 1 276..301 CDD:320378
TM helix 2 310..331 CDD:320378
TM helix 3 397..419 CDD:320378
TM helix 4 440..456 CDD:320378
TM helix 5 478..501 CDD:320378
TM helix 6 531..556 CDD:320378
TM helix 7 579..604 CDD:320378
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 608..613
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..668
PDZ-binding 692..694
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.