Protein Alignment Corin and FZD6

DIOPT Version :9

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001158087.1
• Gene: FZD6 / 8323
• HGNCID: 4044
• Length: 706
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 56/195 - (28%)
• Similarity: 80/195 - (41%)
• Gaps: 28/195 - (14%)

  Fly   778 TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC 842
            ||.||.|..|.  ::.||.|.|||.:||:.|.....:::.:..|.::.|...:..|||..|||.|
Human    23 TCEPITVPRCM--KMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTC 85

  Fly   843 GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFK--------DFPSSEDCVGLDEVR 899
            .:....||||:.||.:....|....|.||:..||.|.|...:        .|....:.:|..:..
Human    86 IEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEFLGPQKKT 150

  Fly   900 EVMR------AATHPKCDGFQ------CDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYC 952
            |.::      ...|.|..|.|      .||  |.|.   |.......|:.:.|| ...|...|:|
Human   151 EQVQRDIGFWCPRHLKTSGGQGYKFLGIDQ--CAPP---CPNMYFKSDELEFAK-SFIGTVSIFC 209

  Fly   953  952
            Human   210  209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	39/123 (32%)
		LDLa	911..942	CDD:238060	9/36 (25%)
		LDLa	945..979	CDD:238060	3/8 (38%)
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
FZD6	NP_001158087.1	CRD_FZ6	20..146	CDD:143559	39/124 (31%)
		Frizzled	189..507	CDD:279827	6/22 (27%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	588..706

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810