DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	425	Identity:	132/425 - (31%)
Similarity:	194/425 - (45%)	Gaps:	96/425 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   970 CPYG--------QDERNCLRLSERNGDVG----------------TGVLEVYRIGQRQWMPACVK 1010
            ||..        |||...|..||.:.:..                ..:||.....|.:|:..|.:
Human    73 CPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFLLEAQVRDQPRWLLVCHE 137

  Fly  1011 NWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFA----- 1070
            .|..|:. ..:|..||:         .:|||.   ..||: |||       |....||||
Human   138 GWSPALG-LQICWSLGH---------LRLTHH---KGVNL-TDI-------KLNSSQEFAQLSPR 181

  Fly  1071 -------------NCKKTEDYPMADLTCSNYECGRVKRGRHKP-SRRIIGGTQASPGNWPFLAAI 1121
                         ||...:   :..|.||  |||.      :| :.||:||...:||.||:.|::
Human   182 LGGFLEEAWQPRNNCTSGQ---VVSLRCS--ECGA------RPLASRIVGGQSVAPGRWPWQASV 235

  Fly  1122 LGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPH 1186
            ..|....  |.|.:::.:||:||:||:.::.:..|..|.:..|:. .:|.....|...|:.:|||
Human   236 ALGFRHT--CGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLV-SHSAVRPHQGALVERIIPH 297

  Fly  1187 PQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYE 1251
            |.|: |..||.|:||.:|.|.:.|.:.:..||||... ::...|:.|.|.|||...   |..||.
Human   298 PLYS-AQNHDYDVALLRLQTALNFSDTVGAVCLPAKE-QHFPKGSRCWVSGWGHTH---PSHTYS 357

  Fly  1252 Y-IVNEVQVPIITRNQCDEWLDNLTVSEG-----MVCAGFDDGGKDACQGDSGGPLLCPYPGEKN 1310
            . ::.:..||:.:...|    ::..|..|     |:|||:.||..|||||||||||:||   :.:
Human   358 SDMLQDTVVPLFSTQLC----NSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCP---DGD 415

  Fly  1311 RWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQE 1345
            .|.:.|:||||..||.|..|||||.|.:::.||.:
Human   416 TWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHD 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060	5/16 (31%)
		SR	980..>1034	CDD:214555	13/69 (19%)
		SRCR	992..1086	CDD:278931	26/111 (23%)
		Tryp_SPc	1103..1343	CDD:214473	90/245 (37%)
		Tryp_SPc	1104..1346	CDD:238113	91/248 (37%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	31/128 (24%)
		Tryp_SPc	217..448	CDD:214473	90/245 (37%)
		Tryp_SPc	218..451	CDD:238113	91/248 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910