DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and prss60.1

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001082915.1	Gene:	prss60.1 / 799770	ZFINID:	ZDB-GENE-070424-25	Length:	387	Species:	Danio rerio

Alignment Length:	259	Identity:	93/259 - (35%)
Similarity:	136/259 - (52%)	Gaps:	27/259 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1101 SRRIIGGTQASPGNWPFLAA----ILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTI 1161
            :.||:||..|..|:||:..:    |.||    .:|.|.||:.:|||||:||:...:...|   .:
Zfish    31 NNRIVGGVNAFDGSWPWQVSLHSPIYGG----HFCGGSLINSEWVLTAAHCLPRITTSSL---LV 88

  Fly  1162 QLG-VTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVR 1225
            .|| .|::...||...:. |..:..||.|| .:.::|||||..|::.|.|..::.||||  .:..
Zfish    89 FLGKTTQQGVNTYEINRT-VSVITVHPSYN-NLTNENDIALLHLSSAVTFSNYIRPVCL--AAQN 149

  Fly  1226 NLHP-GTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGG 1289
            ::.| ||...:.|||..: .........|:.|..:|::..:||:..|.:.:|:..|:|||...||
Zfish   150 SVFPNGTSSWITGWGNIQ-LGVNLPAPGILQETMIPVVPNDQCNALLGSGSVTNNMICAGLLQGG 213

  Fly  1290 KDACQGDSGGPLL---CPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKH 1350
            :|.||||||||::   |..      |...||.|||..||.|..||||..|.||..||...|.::
Zfish   214 RDTCQGDSGGPMVSKQCLV------WVQSGITSWGYGCADPYSPGVYTRVSQYQSWINSIIVQN 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473	90/248 (36%)
		Tryp_SPc	1104..1346	CDD:238113	91/250 (36%)
prss60.1	NP_001082915.1	Tryp_SPc	33..264	CDD:214473	90/248 (36%)
		Tryp_SPc	34..267	CDD:238113	91/250 (36%)
		Somatomedin_B	349..382	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010