DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and FZD3

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_059108.1	Gene:	FZD3 / 7976	HGNCID:	4041	Length:	666	Species:	Homo sapiens

Alignment Length:	804	Identity:	156/804 - (19%)
Similarity:	246/804 - (30%)	Gaps:	306/804 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   745 FNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQL 809
            |:.:|...|:.       |:...:.|       :|.||.:|.||  .:|||.|..||.:.|:.|.
Human     8 FSLWPLTVFMG-------HIGGHSLF-------SCEPITLRMCQ--DLPYNTTFMPNLLNHYDQQ 56

  Fly   810 ETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSL 874
            .....::.:..:|::.|......|||.|:.|.|.:.|....||:.||......|....::||:..
Human    57 TAALAMEPFHPMVNLDCSRDFRPFLCALYAPICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPW 121

  Fly   875 PEYLNCKLFKD----FPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMD 935
            ||.:.|..|.|    :|...|.....|..|....|.. :..||.|      |:|...|
Human   122 PEDMECSRFPDCDEPYPRLVDLNLAGEPTEGAPVAVQ-RDYGFWC------PRELKID------- 172

  Fly   936 QADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCP---YGQDERNCLRLSERNGDVGTGVLEVY 997
                       ||..|       ...|:.|....||   :.::|.:..|               |
Human   173 -----------PDLGY-------SFLHVRDCSPPCPNMYFRREELSFAR---------------Y 204

  Fly   998 RIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNAT--SVLTQLT-----HRPLLATVNVSTDIW 1055
            .||                    :.||:..||...|  :.|..:|     .||::.
Human   205 FIG--------------------LISIICLSATLFTFLTFLIDVTRFRYPERPIIF--------- 240

  Fly  1056 KMYAKRKSTLMQEFANCKKTEDYPMADL------------TC-----SNYECGRVKRGRHKPSRR 1103
                         :|.|     |.|..|            .|     :.|:...|.:|.|..:..
Human   241 -------------YAVC-----YMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACT 287

  Fly  1104 II-----GGTQASPGNWP------FLAAI-LGGPEKIFYCAGVLISDQW--------VLTASH-- 1146
            ::     ..|.|....|.      ||||: ..|.|.|...|.:..:..|        :|.|.:
Human   288 MLFMILYFFTMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKI 352

  Fly  1147 --------C-VGNYSV--------------------------IDLEDWTIQLGVTRRNS------ 1170
                    | ||.|.|                          |.|....|::.:.:.|.
Human   353 EGDNISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVKF 417

  Fly  1171 ------FT-------------------YSG-------QKVKVKAVIPHPQYNMAIAHDNDIALFQ 1203
                  |:                   |.|       |:...:..||.| |.:......|:.||.
Human   418 MIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCP-YQVTQMSRPDLILFL 481

  Fly  1204 LATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGW-----GKREDKDPKSTYEYIVNEVQ----- 1258
            :       ::|:.:.:..|||  ...|:..|...|     |:|:.:        ||||.:
Human   482 M-------KYLMALIVGIPSV--FWVGSKKTCFEWASFFHGRRKKE--------IVNESRQVLQE 529

  Fly  1259 ------------VPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPL---LCPYPGE 1308
                        .|||.:::........|.:.....|..||      |....|.:   :..|.|.
Human   530 PDFAQSLLRDPNTPIIRKSRGTSTQGTSTHASSTQLAMVDD------QRSKAGSIHSKVSSYHGS 588

  Fly  1309 KNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVP-WIQEQIAKHSRPIKEDRVNKYDLHPGGPDIL 1372
            .:|...|...           |..|..:.:.:| ....::..|||.....|:|:...|..    :
Human   589 LHRSRDGRYT-----------PCSYRGMEERLPHGSMSRLTDHSRHSSSHRLNEQSRHSS----I 638

  Fly  1373 SKIATDPMREGAPHHYTHSRTSSK 1396
            ..::.:||.     |.||..:.::
Human   639 RDLSNNPMT-----HITHGTSMNR 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	37/119 (31%)
		LDLa	911..942	CDD:238060	6/30 (20%)
		LDLa	945..979	CDD:238060	8/36 (22%)
		SR	980..>1034	CDD:214555	9/55 (16%)
		SRCR	992..1086	CDD:278931	18/117 (15%)
		Tryp_SPc	1103..1343	CDD:214473	63/360 (18%)
		Tryp_SPc	1104..1346	CDD:238113	63/362 (17%)
FZD3	NP_059108.1	CRD_FZ3	24..150	CDD:143558	39/134 (29%)
		7tmF_FZD3	192..512	CDD:320161	65/391 (17%)
		TM helix 1	201..226	CDD:320161	9/59 (15%)
		TM helix 2	235..256	CDD:320161	7/47 (15%)
		TM helix 3	287..313	CDD:320161	3/25 (12%)
		TM helix 4	330..352	CDD:320161	3/21 (14%)
		TM helix 5	366..391	CDD:320161	2/24 (8%)
		TM helix 6	419..444	CDD:320161	1/24 (4%)
		TM helix 7	473..498	CDD:320161	7/33 (21%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666		27/146 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810