Protein Alignment Corin and Tmprss12

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_898932.2
• Gene: Tmprss12 / 75002
• MGIID: 1922252
• Length: 336
• Species: Mus musculus
• Alignment Length: 346
• Identity: 102/346 - (29%)
• Similarity: 163/346 - (47%)
• Gaps: 48/346 - (13%)

  Fly  1011 NWDRAVSPSAVC--SILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCK 1073
            :|  |:|.:.:|  ....||.:::.|:                        :..|.|.|......
Mouse     3 SW--ALSAALLCLGGAFAYSELHSLSL------------------------REGSALGQATVPGP 41

  Fly  1074 KTEDYPMADLTCSNYECGRVK-RGRHKPSRRIIGGTQASPGNWPFLAA--ILGGPEKIFYCAGVL 1135
            ..|:.|:..      :||... ||..:.| |||||:||..|.||:..:  :..|...:..|.|.|
Mouse    42 PEEEQPVTK------DCGIAPLRGAVEGS-RIIGGSQADTGAWPWQVSLQVQDGDILMHVCGGAL 99

  Fly  1136 ISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIA 1200
            :.|:|||||:||  .....|...|...:|........|..:.:::..:|..|.:.|. ...||||
Mouse   100 VRDRWVLTAAHC--TKEARDPLKWRAVMGTNDLTRSPYHSRNIRITDIIIPPDFIME-TFVNDIA 161

  Fly  1201 LFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRN 1265
            ||:|...|.:::::.|:|||....:.|...|.|.:.|||:..::...:|   |:.|.:|..|:|.
Mouse   162 LFRLKRAVRYNDYIQPICLPFGVFQKLDQNTACFISGWGRTREEGNGTT---ILQEAKVHFISRE 223

  Fly  1266 QC--DEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPR 1328
            .|  |:....: :.....|||.::|..|:|:|||||||:|..| |.:|:||.||.|:|..|....
Mouse   224 VCSSDQGYSGM-IPNTSFCAGHENGTFDSCRGDSGGPLMCYLP-EHSRYFVMGITSYGHGCGRRH 286

  Fly  1329 LPGVYANVVQYVPWIQEQIAK 1349
            .||||:|...:..|:...:::
Mouse   287 FPGVYSNPSFFQEWMTHYLSQ 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	6/24 (25%)
		Tryp_SPc	1104..1346	CDD:238113	84/245 (34%)
Tmprss12	NP_898932.2	Tryp_SPc	66..300	CDD:238113	83/241 (34%)