DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	425	Identity:	142/425 - (33%)
Similarity:	206/425 - (48%)	Gaps:	64/425 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 AKCERCGPDEIYCGDS-QCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQ 1003
            :||...|   |.|..| .||...:.|||:..||.|:||..|:||...|     .:|:||...::.
Human   148 SKCSNSG---IECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPN-----FILQVYSSQRKS 204

  Fly  1004 WMPACVKNWDRAVSPSAVCSILGY-----------SAVNATSVLTQLTHRPLLATVNVSTDIWKM 1057
            |.|.|..:|:.... .|.|..:||           ....:||.:.       |.|...:.||:|
Human   205 WHPVCQDDWNENYG-RAACRDMGYKNNFYSSQGIVDDSGSTSFMK-------LNTSAGNVDIYK- 260

  Fly  1058 YAKRKSTLMQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAIL 1122
                  .|....|...|.    :..|.|  ..|| |.....:.| ||:||..|.||.||:..::
Human   261 ------KLYHSDACSSKA----VVSLRC--IACG-VNLNSSRQS-RIVGGESALPGAWPWQVSL- 310

  Fly  1123 GGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLED---WTIQLGVTRRNSFTYSGQKVKVKAVI 1184
             ..:.:..|.|.:|:.:|::||:|||..    .|.:   ||...|:.|: ||.:.|...:|:.||
Human   311 -HVQNVHVCGGSIITPEWIVTAAHCVEK----PLNNPWHWTAFAGILRQ-SFMFYGAGYQVEKVI 369

  Fly  1185 PHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKST 1249
            .||.|: :...:|||||.:|...:.|::.:.|||||.|.:. |.|..||.:.|||..|:|...|.
Human   370 SHPNYD-SKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMM-LQPEQLCWISGWGATEEKGKTSE 432

  Fly  1250 YEYIVNEVQVPIITRNQCDE--WLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRW 1312
               ::|..:|.:|...:|:.  ..||| ::..|:||||..|..|:|||||||||:   ..:.|.|
Human   433 ---VLNAAKVLLIETQRCNSRYVYDNL-ITPAMICAGFLQGNVDSCQGDSGGPLV---TSKNNIW 490

  Fly  1313 FVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQI 1347
            ::.|..|||..||....||||.||:.:..||..|:
Human   491 WLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060	0/1 (0%)
		LDLa	945..979	CDD:238060	14/34 (41%)
		SR	980..>1034	CDD:214555	14/64 (22%)
		SRCR	992..1086	CDD:278931	22/104 (21%)
		Tryp_SPc	1103..1343	CDD:214473	92/244 (38%)
		Tryp_SPc	1104..1346	CDD:238113	93/246 (38%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060	15/37 (41%)
		SRCR_2	190..283	CDD:292133	26/119 (22%)
		Tryp_SPc	292..521	CDD:214473	92/244 (38%)
		Tryp_SPc	293..524	CDD:238113	93/246 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910