DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Prss22

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006524968.4	Gene:	Prss22 / 70835	MGIID:	1918085	Length:	365	Species:	Mus musculus

Alignment Length:	353	Identity:	111/353 - (31%)
Similarity:	174/353 - (49%)	Gaps:	38/353 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1011 NWDRAVSPSAVC-----------SILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKST 1064
            |..|.:.|.|.|           .:...:|:.:....:.|...|.:..:.:|.....:...:.|.
Mouse    11 NRHRGIKPGATCREPYTLQPPVLPVSSNTALRSFEPASSLAGSPPIPAMMISRPPPALGGDQFSI 75

  Fly  1065 LMQEFANCKKTEDYPMADLTCS-NYECGRVKRGRHKPSR--RIIGGTQASPGNWPFLAAILGGPE 1126
            |:   .....|...|::..|.. :.:||       ||.:  ||:||..:....||::.:||....
Mouse    76 LI---LLVLLTSTAPISAATIRVSPDCG-------KPQQLNRIVGGEDSMDAQWPWIVSILKNGS 130

  Fly  1127 KIFYCAGVLISDQWVLTASHCV-GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYN 1190
              .:|||.|::::||:||:||. .|.....|  :::.||..:..|.....|||.:..|:|||:|:
Mouse   131 --HHCAGSLLTNRWVVTAAHCFKSNMDKPSL--FSVLLGAWKLGSPGPRSQKVGIAWVLPHPRYS 191

  Fly  1191 MAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVN 1255
            .......||||.:|...:.|.|.:||:|||..||| |.|.|.|.:.|||..:|..| ..:...:.
Mouse   192 WKEGTHADIALVRLEHSIQFSERILPICLPDSSVR-LPPKTDCWIAGWGSIQDGVP-LPHPQTLQ 254

  Fly  1256 EVQVPIITRNQCDE--W--LDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGG 1316
            :::||||....|..  |  .....::|||:|||:.:|.:|||.|||||||:|..   .:.|.:.|
Mouse   255 KLKVPIIDSELCKSLYWRGAGQEAITEGMLCAGYLEGERDACLGDSGGPLMCQV---DDHWLLTG 316

  Fly  1317 IVSWGIMCAHPRLPGVYANVVQYVPWIQ 1344
            |:|||..||....||||.:::.:..|:|
Mouse   317 IISWGEGCAERNRPGVYTSLLAHRSWVQ 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	6/33 (18%)
		SRCR	992..1086	CDD:278931	14/85 (16%)
		Tryp_SPc	1103..1343	CDD:214473	91/244 (37%)
		Tryp_SPc	1104..1346	CDD:238113	92/246 (37%)
Prss22	XP_006524968.4	Tryp_SPc	108..346	CDD:238113	92/246 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010