DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Prss41

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001128559.1	Gene:	Prss41 / 681033	RGDID:	1584711	Length:	324	Species:	Rattus norvegicus

Alignment Length:	285	Identity:	100/285 - (35%)
Similarity:	154/285 - (54%)	Gaps:	33/285 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1070 ANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGV 1134
            |..|.|      |:...:..|||    |:....||:||.::..|.||:.|::  ...|...|.|.
  Rat    31 AGLKNT------DIKLLSMPCGR----RNDIRSRIVGGIESVRGRWPWQASL--RLRKFHRCGGS 83

  Fly  1135 LISDQWVLTASHCVGNYSVIDLEDWTIQLG-VTRRNSF----TYSGQKVKVKAVIPHPQYNMAIA 1194
            |:|.:|||||:||...:  :|.:.||:||| :|.:.||    .:|| :.:||.:|.:.:..:..
  Rat    84 LLSHRWVLTAAHCFRKF--LDPKKWTVQLGQLTSKPSFWNREAFSG-RYRVKDIIINSEDKLKY- 144

  Fly  1195 HDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGK-REDKDPKSTYEYIVNEVQ 1258
              :|:||.:||:.|.:::.:.|||:.|.:..:.|. ..|.|.|||. :||..|... .|.:.|||
  Rat   145 --HDLALLRLASSVTYNKFIQPVCVLPSASMSQHQ-PRCWVTGWGALQEDLKPLPP-PYHLREVQ 205

  Fly  1259 VPIITRNQCDEWLDNLT----VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVS 1319
            |.::..::|.|.....:    ::..:.|||.:||..|.|.|||||||:|...|   .|:..||||
  Rat   206 VTVLNLSRCQELFSFASRYHLITRDVFCAGAEDGSADTCSGDSGGPLVCNMDG---LWYQIGIVS 267

  Fly  1320 WGIMCAHPRLPGVYANVVQYVPWIQ 1344
            .|:.|..|:|||:|.||..:..||:
  Rat   268 RGVGCGRPKLPGIYTNVSHHYDWIK 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931	4/15 (27%)
		Tryp_SPc	1103..1343	CDD:214473	90/249 (36%)
		Tryp_SPc	1104..1346	CDD:238113	91/251 (36%)
Prss41	NP_001128559.1	Tryp_SPc	54..291	CDD:214473	90/249 (36%)
Prss41	NP_001128559.1	Tryp_SPc	55..292	CDD:238113	90/249 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010