Protein Alignment Corin and Proz

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_080110.1
• Gene: Proz / 66901
• MGIID: 1860488
• Length: 399
• Species: Mus musculus
• Alignment Length: 555
• Identity: 106/555 - (19%)
• Similarity: 175/555 - (31%)
• Gaps: 190/555 - (34%)

  Fly   826 CYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSE 890
            |..|:..|:.||.:.:...|.....|.........||...:|      |.|.....|.|:  ..|
Mouse     4 CILLLRGFILTLILHQVELSVFLPAPKANNVLRRWRRGSSYF------LEEIFQGNLEKE--CYE 60

  Fly   891 DCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQEY--VCDGHLDCMDQADEAKCERCGPDEIYCG 953
            :....:|.|||.              :|..:..|:  ...|...|:.|    .|...|.    |.
Mouse    61 EVCNYEEAREVF--------------ENDVITDEFWRQYGGGSPCVSQ----PCLNNGT----CE 103

  Fly   954 DSQCIGTKHICDGIIDCPYGQDERNC-LRLSERNGDVGTGVLEVYRIGQRQWMPACVKNW----- 1012
            |       ||......|..|.:.:.| :..:|.:.:...|.......||..:|.:|.|.:
Mouse   104 D-------HIRSYSCTCSPGYEGKTCAMAKNECHLERTDGCQHFCHPGQSSYMCSCAKGYKLGKD 161

  Fly  1013 DRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTED 1077
            .::..||..|:
Mouse   162 QKSCGPSDKCA------------------------------------------------------ 172

  Fly  1078 YPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVL 1142
                        ||.: ...|   .|:...:|:.| ::|:...:.....:.| |||||:.:.:||
Mouse   173 ------------CGAL-TSEH---IRMTKSSQSQP-SFPWQVRLTNSEGEDF-CAGVLLQEDFVL 219

  Fly  1143 TASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATR 1207
            |.:.|...:|.|     :::..|         .|::::|:...|.:|:.. :.:||::|.||...
Mouse   220 TTAKCSLLHSNI-----SVKANV---------DQRIRIKSTHVHMRYDEE-SGENDVSLLQLEEP 269

  Fly  1208 VAFHEHLLPVCLPPPSVRN--LHPGTLCTVIGW---GKREDKDP------KSTYEYIVNEVQVPI 1261
            :......||||:|......  |.|||...:.||   |......|      ::..|.....:.|.:
Mouse   270 LQCPSSGLPVCVPERDFAEHVLIPGTEGLLSGWMLNGTHLATTPMLLSVTQADGEECGQTLNVTV 334

  Fly  1262 ITRNQCDE-------WLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVS 1319
            .||..|::       |::...|:.                            ..|..||:.||:
Mouse   335 TTRTSCEKGSVVMGPWVEGSVVTR----------------------------EHKGTWFLTGIL- 370

  Fly  1320 WGIMCAHPRLPG-----VYANVVQYVPWIQEQIAK 1349
                 ..|..||     :...|.:|..|. :||.|
Mouse   371 -----GSPPPPGQSQMLLLTAVPRYSMWF-KQIMK 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	15/67 (22%)
		LDLa	911..942	CDD:238060	5/32 (16%)
		LDLa	945..979	CDD:238060	7/33 (21%)
		SR	980..>1034	CDD:214555	10/58 (17%)
		Tryp_SPc	1104..1346	CDD:238113	56/264 (21%)
Proz	NP_080110.1	GLA	23..85	CDD:214503	16/83 (19%)
		EGF_CA	<95..122	CDD:238011	8/37 (22%)
		FXa_inhibition	136..165	CDD:464251	6/28 (21%)
		Trypsin	192..>340	CDD:459667	40/163 (25%)