DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and TMPRSS3

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_076927.1	Gene:	TMPRSS3 / 64699	HGNCID:	11877	Length:	454	Species:	Homo sapiens

Alignment Length:	429	Identity:	131/429 - (30%)
Similarity:	200/429 - (46%)	Gaps:	57/429 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   930 HLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVL 994
            |.||   :.:.:|.         ...:||.....|||:.||..|:||..|:|:..:|     .||
Human    70 HFDC---SGKYRCR---------SSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQN-----AVL 117

  Fly   995 EVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIW---- 1055
            :|:...  .|...|..:| :....:..|:.||:.:..::..|...:.........||.|..
Human   118 QVFTAA--SWKTMCSDDW-KGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDD 179

  Fly  1056 KMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAA 1120
            |:.|...|..::|  .|....   :..|.|:  .||. :||.   |.||:||..:....||:.|:
Human   180 KVTALHHSVYVRE--GCASGH---VVTLQCT--ACGH-RRGY---SSRIVGGNMSLLSQWPWQAS 233

  Fly  1121 ILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIP 1185
            :..  :....|.|.:|:..|::||:|||  |.:...:.||||:|:.  :..........|:.::.
Human   234 LQF--QGYHLCGGSVITPLWIITAAHCV--YDLYLPKSWTIQVGLV--SLLDNPAPSHLVEKIVY 292

  Fly  1186 HPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKRE----DKDP 1246
            |.:|... ...|||||.:||..:.|:|.:.|||| |.|..|...|.:|...|||..|    |..|
Human   293 HSKYKPK-RLGNDIALMKLAGPLTFNEMIQPVCL-PNSEENFPDGKVCWTSGWGATEDGAGDASP 355

  Fly  1247 KSTYEYIVNEVQVPIITRNQCDEW-LDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKN 1310
                  ::|...||:|:...|:.. :....:|..|:|||:..||.|:|||||||||:|.   |:.
Human   356 ------VLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQ---ERR 411

  Fly  1311 RWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAK 1349
            .|.:.|..|:||.||....||||..|..::.||.||:.:
Human   412 LWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMER 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060	3/11 (27%)
		LDLa	945..979	CDD:238060	10/33 (30%)
		SR	980..>1034	CDD:214555	11/53 (21%)
		SRCR	992..1086	CDD:278931	19/97 (20%)
		Tryp_SPc	1103..1343	CDD:214473	85/244 (35%)
		Tryp_SPc	1104..1346	CDD:238113	86/246 (35%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060	11/41 (27%)
		SRCR_2	112..210	CDD:292133	23/113 (20%)
		Tryp_SPc	216..444	CDD:214473	85/244 (35%)
		Tryp_SPc	217..447	CDD:238113	86/246 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910