DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Fzd4

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_072145.1	Gene:	Fzd4 / 64558	RGDID:	71017	Length:	538	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	53/193 - (27%)
Similarity:	80/193 - (41%)	Gaps:	32/193 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 KNPAPG-------TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYEL 829
            :.||.|       .|.||.:..||  .:.||.|..||.:||..|.:.:..|.::..|:...|...
  Rat    32 QRPALGFGDEEERRCDPIRIAMCQ--NLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQ 94

  Fly   830 VSLFLCTLFVPKCGQS-GATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSED-- 891
            :..|||:::||.|.:. ...:.||..:|....|||......||.:.|:.|||   ..||...|
  Rat    95 LQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPDSLNC---SKFPPQNDHN 156

  Fly   892 --CV---GLDEVREVMRAATHPKCDGFQCDQNRCLPQEYV-CDGHLDCMDQADEAKCERCGPD 948
              |:   |.:||....:....|   |.:|........:|: ....|:|:        .:||.|
  Rat   157 HMCMEGPGDEEVPLPHKTPIQP---GEECHSVGTNSDQYIWVKRSLNCV--------LKCGYD 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	38/123 (31%)
		LDLa	911..942	CDD:238060	5/31 (16%)
		LDLa	945..979	CDD:238060	3/4 (75%)
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	39/129 (30%)
		Frizzled	211..510	CDD:279827
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505
		PDZ-binding	536..538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900