DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and SFRP5

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_003006.2	Gene:	SFRP5 / 6425	HGNCID:	10779	Length:	317	Species:	Homo sapiens

Alignment Length:	260	Identity:	65/260 - (25%)
Similarity:	99/260 - (38%)	Gaps:	33/260 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   769 SFGKNPAPGTCL--PIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVS 831
            |:.|   |..||  |..:..|.  .:.|.....||.:.|....|.:....|:..|:..||:....
Human    46 SYSK---PPQCLDIPADLPLCH--TVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQ 105

  Fly   832 LFLCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSED-CVGL 895
            :|||:||.|.|  ....:.||::||......|....:.:|...||.|:|   ..||...| |:.
Human   106 VFLCSLFAPVC--LDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHC---HKFPLDNDLCIA- 164

  Fly   896 DEVREVMRAATHPKCDGF--QCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCI 958
              |:.....||.|.....  ||:      .|:..||.::.|..:|.....|....:|..||.:.|
Human   165 --VQFGHLPATAPPVTKICAQCE------MEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLI 221

  Fly   959 GTKHICDGIIDCPYGQDERNCLRLSERNG---------DVGTGVLEVYRIGQRQWMPACVKNWDR 1014
            |.:.....:...|..:.:...|.|..:||         .:....|.:.|....|.:...|..||:
Human   222 GAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDK 286

Fly 1015 1014
Human 287 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	34/118 (29%)
		LDLa	911..942	CDD:238060	7/32 (22%)
		LDLa	945..979	CDD:238060	6/33 (18%)
		SR	980..>1034	CDD:214555	10/44 (23%)
		SRCR	992..1086	CDD:278931	6/23 (26%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
SFRP5	NP_003006.2	CRD_SFRP5	47..173	CDD:143553	37/138 (27%)
SFRP5	NP_003006.2	NTR_Sfrp1_like	178..303	CDD:239635	24/115 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810