DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and SFRP1

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_003003.3	Gene:	SFRP1 / 6422	HGNCID:	10776	Length:	314	Species:	Homo sapiens

Alignment Length:	334	Identity:	72/334 - (21%)
Similarity:	112/334 - (33%)	Gaps:	90/334 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   718 GRLKFRLFQILINAFALLAIAGGLAAY--------FNAYPTIKFVNKTIINTIHVEDTTSFGKNP 774
            ||....|..:|....||||: |..:.|        ...|.:.:|..|
Human     9 GRRGAALGVLLALGAALLAV-GSASEYDYVSFQSDIGPYQSGRFYTK------------------ 54

  Fly   775 APGTC--LPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTL 837
             |..|  :|..:|.|.  .:.|...|.||.:.|....|.:....|:..|::..|:....:|||:|
Human    55 -PPQCVDIPADLRLCH--NVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSL 116

  Fly   838 FVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGL-----DE 897
            |.|.|  ....:.||:.||......|......||...||.|.|   ..||..:.|:.:     .|
Human   117 FAPVC--LDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKC---DKFPEGDVCIAMTPPNATE 176

  Fly   898 VREVMRAATHPKCDGFQCDQNRCLPQ---EYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIG 959
            ..:.......|.||      |....:   |::|........:..|.|.|.        ||.:.:.
Human   177 ASKPQGTTVCPPCD------NELKSEAIIEHLCASEFALRMKIKEVKKEN--------GDKKIVP 227

  Fly   960 TK-------------------HICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWM 1005
            .|                   ::.:| .|||       |.:|.    ::....|.:.|..:.|::
Human   228 KKKKPLKLGPIKKKDLKKLVLYLKNG-ADCP-------CHQLD----NLSHHFLIMGRKVKSQYL 280

  Fly  1006 PACVKNWDR 1014
            ...:..||:
Human   281 LTAIHKWDK 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	34/117 (29%)
		LDLa	911..942	CDD:238060	5/33 (15%)
		LDLa	945..979	CDD:238060	7/52 (13%)
		SR	980..>1034	CDD:214555	6/35 (17%)
		SRCR	992..1086	CDD:278931	5/23 (22%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
SFRP1	NP_003003.3	CRD_SFRP1	52..175	CDD:143552	36/148 (24%)
SFRP1	NP_003003.3	NTR_Sfrp1_like	183..306	CDD:239635	23/133 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810