Protein Alignment Corin and tmprss5

DIOPT Version :9

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_009289870.1
• Gene: tmprss5 / 569688
• ZFINID: ZDB-GENE-131121-184
• Length: 551
• Species: Danio rerio
• Alignment Length: 578
• Identity: 164/578 - (28%)
• Similarity: 260/578 - (44%)
• Gaps: 113/578 - (19%)

  Fly   829 LVSLFLCTLFVPKCGQ-SGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPS---- 888
            |.||.||.:.:.:|.| :|.|....:.||.:.           |..:.|..:|.  ::.|:
Zfish    31 LTSLSLCEVKIQRCIQLNGLTAAGVEHLCCDG-----------GKLMRESSSCS--QEIPNPNNE 82

  Fly   889 ----SEDCVGLDEVREVMRAATHP---KCDGFQCDQN--RCLPQ---EYVCDGHLDC--MDQADE 939
                |.|.|.:.|...|:|.:.||   :.|..:.|||  |||.:   .:...|.:..  :.:...
Zfish    83 SMSLSRDAVAVIENPVVVRQSFHPESLQVDMLESDQNNHRCLRELQFLHPVSGKVSSRKLVRVFA 147

  Fly   940 AKCERC-----------------------GPDEIYCGDSQCIGTKHICDGIIDCPYGQDERNCLR 981
            |.|..|                       .|..:  ||::   ....|:...|.......:...|
Zfish   148 ALCVLCLLGGVVVGVWFIVKFLLKPNLSQSPASL--GDTK---DTSFCNVTEDISVTDPRKVFYR 207

  Fly   982 LSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGY------SAVNATSVLTQLT 1040
            :|..|     .:||:.....:.|:|.|.:.|:.::. :.||..|||      ..||.|.:....|
Zfish   208 ISAEN-----SLLEIQLEKLQTWLPVCFERWNSSLG-TLVCRQLGYLRLSKHKGVNLTDIGPNYT 266

  Fly  1041 HRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYECG-RVKRGRHKPSRRI 1104
            .    ..|.::::    |.....:|.:...:|...:   :..|.|  :||| |.|      ..||
Zfish   267 D----GFVQITSE----YQSNLESLWRFRGSCSTGK---VIALKC--FECGTRAK------LPRI 312

  Fly  1105 IGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRN 1169
            |||.:|:.|.||:..::......|  |.|.:|::||::||:|||.||.:..:..|.:..|:...|
Zfish   313 IGGVEAALGRWPWQVSLYYNNRHI--CGGSIITNQWIVTAAHCVHNYRLPQVPSWVVYAGIITSN 375

  Fly  1170 ---SFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGT 1231
               ...|.|  ..|:.:|.:..||.. .|||||||.:|.|.:.|.:.:.|||||... .:|..||
Zfish   376 LAKLAQYQG--FAVERIIYNKNYNHR-THDNDIALVKLKTPLNFSDTIRPVCLPQYD-HDLPGGT 436

  Fly  1232 LCTVIGWGKREDKD---PKSTYEYIVNEVQVPIITRNQCD-EWLDNLTVSEGMVCAGFDDGGKDA 1292
            .|.:.|||..:..|   |:     ::.|..||:|:..:|: ..:.|..::..|:|||:.:|..||
Zfish   437 QCWISGWGYTQPDDVLIPE-----VLKEAPVPLISTKKCNSSCMYNGEITSRMLCAGYSEGKVDA 496

  Fly  1293 CQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKH 1350
            |||||||||:|.   ::|.|.:.|:||||..||.|..||||:.|.:::.||.:.|..:
Zfish   497 CQGDSGGPLVCQ---DENVWRLVGVVSWGTGCAEPNHPGVYSKVAEFLGWIYDIIESY 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	17/73 (23%)
		LDLa	911..942	CDD:238060	9/37 (24%)
		LDLa	945..979	CDD:238060	6/56 (11%)
		SR	980..>1034	CDD:214555	16/59 (27%)
		SRCR	992..1086	CDD:278931	20/99 (20%)
		Tryp_SPc	1103..1343	CDD:214473	93/246 (38%)
		Tryp_SPc	1104..1346	CDD:238113	94/248 (38%)
tmprss5	XP_009289870.1	SRCR_2	211..306	CDD:292133	25/113 (22%)
		Tryp_SPc	311..544	CDD:214473	93/246 (38%)
		Tryp_SPc	312..547	CDD:238113	94/248 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910