DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and sfrp2

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001070852.2	Gene:	sfrp2 / 566878	ZFINID:	ZDB-GENE-061013-293	Length:	294	Species:	Danio rerio

Alignment Length:	193	Identity:	50/193 - (25%)
Similarity:	73/193 - (37%)	Gaps:	32/193 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   729 INAFALLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTS-FGKNPAPGTCLPIIVRFCQGPQI 792
            :.|:..|.:|..:..|.:|           ::.::..|... |.|.   ..|.||.........|
Zfish     1 MRAYLALLVALSIPGYLDA-----------LHGLYAFDQPELFQKK---SNCKPIPTNLLLCHDI 51

  Fly   793 PYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC-GQSGATVPPCKTLC 856
            .|.....||.:||....|......|:..||..:|:.....|||:||.|.| ......:.||::||
Zfish    52 EYTNMRLPNLLGHETMNEVLQQASSWTPLVQKQCHPDTKKFLCSLFAPVCLDDLDEPIQPCRSLC 116

  Fly   857 TETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSED-CV---GLDEV----REVMRAATHPKCD 911
            ......|......||...|:.|:|   :.||...| |:   |.|.:    :||.|.     ||
Zfish   117 ESVKSGCAPVMAAFGFPWPDMLDC---RRFPLDNDLCIPPAGADALVPVTKEVPRV-----CD 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	35/120 (29%)
		LDLa	911..942	CDD:238060	1/1 (100%)
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
sfrp2	NP_001070852.2	CRD_SFRP2	34..161	CDD:143555	38/132 (29%)
sfrp2	NP_001070852.2	NTR_Sfrp1_like	167..294	CDD:239635	3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900