DRSC/TRiP Functional Genomics Resources

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Protein Alignment Corin and TMPRSS4

DIOPT Version :9

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:XP_005271670.1 Gene:TMPRSS4 / 56649 HGNCID:11878 Length:494 Species:Homo sapiens


Alignment Length:479 Identity:137/479 - (28%)
Similarity:210/479 - (43%) Gaps:96/479 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   948 DEIY--CGDS-QCIGTKHICDGIIDCPYGQDERNC-----------LRLSERNGDVGTGVLEVYR 998
            |:.|  ||.. ..|..|.:|||.:|||.|:||.:|           :|||:   |..|  |:|..
Human    58 DKYYFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSK---DRST--LQVLD 117

  Fly   999 IGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKS 1063
            .....|..||..|:..|::.:| |..:|||:            :|....|.:..|          
Human   118 SATGNWFSACFDNFTEALAETA-CRQMGYSS------------KPTFRAVEIGPD---------- 159

  Fly  1064 TLMQEFANCKKTEDYPMADLTCSNYECGRVKR------------------GRHKPSRRIIGGTQA 1110
                        :|..:.::|.::.|. |::.                  |:...:.|::|..:|
Human   160 ------------QDLDVVEITENSQEL-RMRNSSGPCLSGSLVSLHCLACGKSLKTPRVVGVEEA 211

  Fly  1111 SPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSG 1175
            |..:||:..:|  ..:|...|.|.::...|||||:||...::  |:.:|.::.|..:..||. |.
Human   212 SVDSWPWQVSI--QYDKQHVCGGSILDPHWVLTAAHCFRKHT--DVFNWKVRAGSDKLGSFP-SL 271

  Fly  1176 QKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGK 1240
            ...|:..:..:|.|    ..||||||.:|...:.|...:.|:|||... ..|.|.|...:||||.
Human   272 AVAKIIIIEFNPMY----PKDNDIALMKLQFPLTFSGTVRPICLPFFD-EELTPATPLWIIGWGF 331

  Fly  1241 REDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPY 1305
            .:....|.:...:...|||...||...|:.... .|:|.|:|||..:||.|.|||||||||:.  
Human   332 TKQNGGKMSDILLQASVQVIDSTRCNADDAYQG-EVTEKMMCAGIPEGGVDTCQGDSGGPLMY-- 393

  Fly  1306 PGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRPIKEDRVNKYDLHPGGPD 1370
              :.::|.|.||||||..|..|..||||..|..|:.||..        :.:||..:...:..|..
Human   394 --QSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYN--------VWKDRTIQRSCNSPGTG 448

  Fly  1371 ILSKIATDPMREGAPHHYTHSRTS 1394
            ::.:....|:.|.....:||..|:
Human   449 LVIQQPAVPLMELRSARHTHRLTT 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549
LDLa 911..942 CDD:238060
LDLa 945..979 CDD:238060 15/33 (45%)
SR 980..>1034 CDD:214555 17/53 (32%)
SRCR 992..1086 CDD:278931 17/93 (18%)
Tryp_SPc 1103..1343 CDD:214473 86/239 (36%)
Tryp_SPc 1104..1346 CDD:238113 87/241 (36%)
TMPRSS4XP_005271670.1 LDLa 58..92 CDD:238060 15/33 (45%)
SRCR_2 108..197 CDD:295335 21/129 (16%)
Tryp_SPc 204..429 CDD:214473 86/239 (36%)
Tryp_SPc 205..432 CDD:238113 87/249 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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