DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and fzd3a

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_005160805.1	Gene:	fzd3a / 565921	ZFINID:	ZDB-GENE-990415-225	Length:	686	Species:	Danio rerio

Alignment Length:	189	Identity:	52/189 - (27%)
Similarity:	84/189 - (44%)	Gaps:	25/189 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   757 TIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEAL 821
            |:...|::|.|.|.    :..:|.||.:|.|||  :.||.|..||.:.|:.|......::.:..:
Zfish    12 TVCMAINMEATGSH----SMFSCEPITLRMCQG--LAYNTTFMPNLLNHYDQQTAALAMEPFHPM 70

  Fly   822 VDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLF--- 883
            |::.|...:..|||.|:.|.|.:.|....||:.||......|....::||:|.|:.:.|..|
Zfish    71 VNLECSTEIRPFLCALYAPVCTEYGRVTLPCRRLCQRAKSDCYKLMEMFGVSWPDEMECSRFPEC 135

  Fly   884 -KDFPSSEDCVGLDEVREVMRAATHPKCDGFQCDQNRCLPQE--------YVCDGHLDC 933
             :.:|.:.|.:...:..|...:|.. :..||.|      |:|        |...|..||
Zfish   136 EESYPRAIDLLPSSDSTEESPSAVQ-RDYGFWC------PRELKIEPDLGYSFMGVRDC 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	36/119 (30%)
		LDLa	911..942	CDD:238060	9/31 (29%)
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
fzd3a	XP_005160805.1	CRD_FZ3	26..152	CDD:143558	36/127 (28%)
fzd3a	XP_005160805.1	Frizzled	195..513	CDD:279827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900