DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and PRSS8

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_002764.1	Gene:	PRSS8 / 5652	HGNCID:	9491	Length:	343	Species:	Homo sapiens

Alignment Length:	265	Identity:	101/265 - (38%)
Similarity:	141/265 - (53%)	Gaps:	33/265 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1100 PSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLG 1164
            |..||.||:.|..|.||:..:|.  .|.:..|.|.|:|:||||:|:||..  |....|.:.::||
Human    41 PQARITGGSSAVAGQWPWQVSIT--YEGVHVCGGSLVSEQWVLSAAHCFP--SEHHKEAYEVKLG 101

  Fly  1165 VTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSV---RN 1226
            ..:.:|::...:...:|.:||||.| :......||||.||:..:.|..::.|:|||..:.   ..
Human   102 AHQLDSYSEDAKVSTLKDIIPHPSY-LQEGSQGDIALLQLSRPITFSRYIRPICLPAANASFPNG 165

  Fly  1227 LHPGTLCTVIGWGKREDK----DPKSTYEYIVNEVQVPIITRNQCDEWLDNLT--------VSEG 1279
            ||    |||.|||.....    .||.     :.:::||:|:|..|: .|.|:.        |.|.
Human   166 LH----CTVTGWGHVAPSVSLLTPKP-----LQQLEVPLISRETCN-CLYNIDAKPEEPHFVQED 220

  Fly  1280 MVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQ 1344
            |||||:.:||||||||||||||.||..|   .|::.||||||..|.....||||.....|..|||
Human   221 MVCAGYVEGGKDACQGDSGGPLSCPVEG---LWYLTGIVSWGDACGARNRPGVYTLASSYASWIQ 282

  Fly  1345 EQIAK 1349
            .::.:
Human   283 SKVTE 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473	97/254 (38%)
		Tryp_SPc	1104..1346	CDD:238113	99/256 (39%)
PRSS8	NP_002764.1	Tryp_SPc	44..281	CDD:214473	97/254 (38%)
PRSS8	NP_002764.1	Tryp_SPc	45..284	CDD:238113	99/256 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010