Protein Alignment Corin and PRSS3

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001184026.3
• Gene: PRSS3 / 5646
• HGNCID: 9486
• Length: 261
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 88/279 - (31%)
• Similarity: 133/279 - (47%)
• Gaps: 48/279 - (17%)

  Fly  1093 VKRGR------HKPSR----------RIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWV 1141
            :|:||      |.|..          :|:||......:.|:..::..|..   :|.|.|||:|||
Human    11 LKKGRSAPLVFHPPDALIAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSH---FCGGSLISEQWV 72

  Fly  1142 LTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSG--QKVKVKAVIPHPQYNMAIAHDNDIALFQL 1204
            ::|:||   |..      .||:.:...|.....|  |.:....:|.||:||.... ||||.|.:|
Human    73 VSAAHC---YKT------RIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTL-DNDIMLIKL 127

  Fly  1205 ATRVAFHEHLLPVCLP--PPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQC 1267
            ::....:..:..:.||  ||:.     ||.|.:.|||......  :.|...:..:..|::|:.:|
Human   128 SSPAVINARVSTISLPTTPPAA-----GTECLISGWGNTLSFG--ADYPDELKCLDAPVLTQAEC 185

  Fly  1268 DEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGV 1332
            ...... .::..|.|.||.:||||:||.|||||::|  .|:     :.|:||||..||....|||
Human   186 KASYPG-KITNSMFCVGFLEGGKDSCQRDSGGPVVC--NGQ-----LQGVVSWGHGCAWKNRPGV 242

  Fly  1333 YANVVQYVPWIQEQIAKHS 1351
            |..|..||.||::.||.:|
Human   243 YTKVYNYVDWIKDTIAANS 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	80/245 (33%)
PRSS3	NP_001184026.3	Tryp_SPc	38..256	CDD:238113	80/245 (33%)