DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and col18a1a

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	258	Identity:	66/258 - (25%)
Similarity:	87/258 - (33%)	Gaps:	49/258 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 SASNNNNGSSVASDGSQ--------LPVVPARKQPPPVKGSSNSSNSIGETQSQSSKEPSSVSAS 434
            |||:.:.|........|        |..||.....|.:.|........||...     |..|...
Zfish   796 SASSGSGGFGPPGPPGQNGAPGQPGLSGVPGADGKPGLPGPKGEKGDAGELGL-----PGPVGEK 855

  Fly   435 ASTSSAASAGSSTISSGTMSSMSGPCPAVVPPTDAITKRPGPPEPPLRQANV-FDPVETGSRGHP 498
            .:..|:...|::.|  |..:.:.||    :.|...    ||||.||....|| ||.:| ||..|.
Zfish   856 GAKGSSGPPGTTGI--GGPAGLPGP----IGPIGL----PGPPGPPGPSFNVGFDDME-GSGVHF 909

  Fly   499 PPPLTVRNKLGRNKPPPITYPRMQQRQDSTLSSDSYSISSSPGYNSKLMEAPLLGSQQGGRKSNA 563
            .....||..:|...||.:..|:.|                 ||:.....|...||:|.......|
Zfish   910 SSVPGVRGPVGIPGPPGVPGPQGQ-----------------PGFPGLPGEKGSLGAQGNDGLPGA 957

  Fly   564 PGSAQRQTPLMDLAPTRFLGGAGGGTGSGKQG-PAMPPPRSKINFRQDSTISSDSFSQTSSPG 625
            .|....|.|..|.. .|...|..|..|.|..| |..|.|..:|.:|.     |:.:.:....|
Zfish   958 DGFPGPQGPKGDKG-ERGDRGEPGRDGHGHPGQPGPPGPPGQIIYRY-----SEHYDEVGGTG 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564
		LamG	327..516	CDD:328935
		Collagen	816..860	CDD:189968	9/48 (19%)
		Collagen	<937..980	CDD:189968	11/43 (26%)
		Collagen	959..1055	CDD:189968	17/62 (27%)
		Endostatin	1471..1639	CDD:310825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900