Protein Alignment Corin and PROC

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_024308771.1
• Gene: PROC / 5624
• HGNCID: 9451
• Length: 556
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 164/597 - (27%)
• Similarity: 227/597 - (38%)
• Gaps: 171/597 - (28%)

  Fly   825 RCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETMR---------RCGFFFDVFGLSLPEYLNC 880
            |.::|.||.   |||...|.|| |..|..::.:.:.|         |...|       |.|..:.
Human    61 RMWQLTSLL---LFVATWGISG-TPAPLDSVFSSSERAHQVLRIRKRANSF-------LEELRHS 114

  Fly   881 KLFKDFPSSEDCVGLDEVREVMR------AATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADE 939
            .|.::  ..|:....:|.:|:.:      |......||.||   ..||.|:.|
Human   115 SLERE--CIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQC---LVLPLEHPC------------ 162

  Fly   940 AKCERCGPDEIYCGDSQCIGTKHICDGI----IDCPYGQDERNCLRLSERNGDVGTGVLEVYRIG 1000
                    ..:.||...||      |||    .||..|.:.|.|.|        |.|
Human   163 --------ASLCCGHGTCI------DGIGSFSCDCRSGWEGRFCQR--------GEG-------- 197

  Fly  1001 QRQWMPA-----CVKNWDRAVSPS-------AVCSILGYSAVNATSVLTQLTHRPLLATVNVSTD 1053
             .:||.|     ....|.|..|.|       |..|.|..|..|.     ..||. .|..|.
Human   198 -ERWMLAGGGAGLGPGWGRGTSTSCPRPPLPAEVSFLNCSLDNG-----GCTHY-CLEEVG---- 251

  Fly  1054 IWKMYAKRKSTLMQEFANCKKTEDYPMAD--LTCS---NYECGRV-KRGRHKPSR---------- 1102
             |:              .|.....|.:.|  |.|.   .:.|||. ||...|.|.
Human   252 -WR--------------RCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQED 301

  Fly  1103 ----RIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHC----------VGNYSV 1153
                |:|.|.....|:.|:...:|...:|: .|..|||...|||||:||          :|.|.:
Human   302 QVDPRLIDGKMTRRGDSPWQVVLLDSKKKL-ACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDL 365

  Fly  1154 IDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVC 1218
            ...|.|.:.|               .:|.|..||.|:.:.. ||||||..||......:.::|:|
Human   366 RRWEKWELDL---------------DIKEVFVHPNYSKSTT-DNDIALLHLAQPATLSQTIVPIC 414

  Fly  1219 LPPPSV--RNLH-PGTLCTVIGWG--KREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSE 1278
            ||...:  |.|: .|....|.|||  ...:|:.|....:::|.:::|::..|:|.|.:.|: |||
Human   415 LPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNM-VSE 478

  Fly  1279 GMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWI 1343
            .|:|||.....:|||:||||||::..:.|   .||:.|:||||..|......|||..|.:|:.||
Human   479 NMLCAGILGDRQDACEGDSGGPMVASFHG---TWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 540

  Fly  1344 QEQIAKHSRPIK 1355
            ...|.....|.|
Human   541 HGHIRDKEAPQK 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	19/77 (25%)
		LDLa	911..942	CDD:238060	8/30 (27%)
		LDLa	945..979	CDD:238060	11/37 (30%)
		SR	980..>1034	CDD:214555	15/65 (23%)
		Tryp_SPc	1104..1346	CDD:238113	86/256 (34%)
PROC	XP_024308771.1	GLA	85..148	CDD:214503	10/71 (14%)
		EGF_CA	162..193	CDD:238011	12/56 (21%)
		FXa_inhibition	235..270	CDD:464251	11/59 (19%)
		Tryp_SPc	308..543	CDD:238113	86/255 (34%)