DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and frzb2

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001016688.2	Gene:	frzb2 / 549442	XenbaseID:	XB-GENE-876718	Length:	300	Species:	Xenopus tropicalis

Alignment Length:	255	Identity:	54/255 - (21%)
Similarity:	84/255 - (32%)	Gaps:	69/255 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   778 TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC 842
            |.:|..:..|.  .|.|:....||.:.|....|......|:..|:...|:....:|||:||.|.|
Frog    44 TRIPRSMALCY--DIGYSEMRIPNLLEHDTMAEVIQQSSSWLPLLARECHPDARIFLCSLFAPIC 106

  Fly   843 GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATH 907
              ....:.||::||......|......:|...||.|
Frog   107 --LDRYIYPCRSLCEAVRGSCAPIMACYGYPWPEIL----------------------------- 140

  Fly   908 PKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCPY 972
             :||.|..|...|:..  :.:|..........|.|..|..:|       ....|.|.|...|
Frog   141 -RCDKFPEDHGMCISP--ITNGTGSTRRTVPRASCRDCELEE-------ASTAKEILDTFCD--- 192

  Fly   973 GQDERNCLRLSERN--------GDVGTGVLEVYRIGQ----------RQWM---PACVKN 1011
             .|....:|::::|        .|:.: .||:.:.|.          :||:   ..||:|
Frog   193 -NDFVAKVRITKKNITSANLYDFDLDS-KLEILKHGSLPKTDVLPRLQQWLDLDATCVQN 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	28/115 (24%)
		LDLa	911..942	CDD:238060	6/30 (20%)
		LDLa	945..979	CDD:238060	7/33 (21%)
		SR	980..>1034	CDD:214555	11/53 (21%)
		SRCR	992..1086	CDD:278931	8/33 (24%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
frzb2	NP_001016688.2	CRD_crescent	41..175	CDD:143562	36/166 (22%)
frzb2	NP_001016688.2	NTR_Sfrp1_like	169..298	CDD:239635	20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910