DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and prss60.2

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001099071.1	Gene:	prss60.2 / 541408	ZFINID:	ZDB-GENE-050320-109	Length:	328	Species:	Danio rerio

Alignment Length:	306	Identity:	100/306 - (32%)
Similarity:	147/306 - (48%)	Gaps:	76/306 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1083 LTCSNYE--------------CGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI----LGGPEKIF 1129
            |||:...              ||:...     :.||:||..|..|:||:..::    .||    .
Zfish     4 LTCATLTLLICVKGSLSQLNVCGQAPL-----NSRIVGGVNAPEGSWPWQVSLQSPRYGG----H 59

  Fly  1130 YCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVK-----------VKAV 1183
            :|.|.|||.:|||||:||:.              ||:..:...|.|::.:           |..:
Zfish    60 FCGGSLISSEWVLTAAHCLP--------------GVSESSLVVYLGRRTQQGVNTHETSRNVAKI 110

  Fly  1184 IPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRN--LHPGTLCTVIGWGKREDKDP 1246
            |.|..|| :..:||||||.:|::.|.|::::.||||   :.:|  ...||...:.|||     |.
Zfish   111 IVHSSYN-SNTNDNDIALLRLSSAVTFNDYIRPVCL---AAQNSVYSAGTSSWITGWG-----DV 166

  Fly  1247 KSTYEY----IVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPL---LCP 1304
            ::....    |:.|..:|::..::|:..|.:.||:..|:|||...||||.||||||||:   ||.
Zfish   167 QAGVNLPAPGILQETMIPVVANDRCNAQLGSGTVTNNMICAGLAKGGKDTCQGDSGGPMVTRLCT 231

  Fly  1305 YPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKH 1350
            .      |...||.|||..||.|..||||..|.||..||..:|:::
Zfish   232 V------WIQAGITSWGYGCADPNSPGVYTRVSQYQSWISSKISQN 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931	2/2 (100%)
		Tryp_SPc	1103..1343	CDD:214473	92/263 (35%)
		Tryp_SPc	1104..1346	CDD:238113	93/265 (35%)
prss60.2	NP_001099071.1	Tryp_SPc	33..264	CDD:214473	92/263 (35%)
		Tryp_SPc	34..267	CDD:238113	93/265 (35%)
		Somatomedin_B	296..326	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010