Protein Alignment Corin and PLG

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_000292.1
• Gene: PLG / 5340
• HGNCID: 9071
• Length: 810
• Species: Homo sapiens
• Alignment Length: 724
• Identity: 161/724 - (22%)
• Similarity: 260/724 - (35%)
• Gaps: 235/724 - (32%)

  Fly   786 FCQG----PQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKC---- 842
            :|:.    ||.|:.||..|.                       :.|:...:..|......|
Human   151 YCRNPDNDPQGPWCYTTDPE-----------------------KRYDYCDILECEEECMHCSGEN 192

  Fly   843 --GQSGATVP--PCKTLCTETMRRCGFFFDVFGLSLP-EYLNCKLFKDFPSSED------CVGLD 896
              |:...|:.  .|:...:::....|:        :| ::.|..|.|::..:.|      |...|
Human   193 YDGKISKTMSGLECQAWDSQSPHAHGY--------IPSKFPNKNLKKNYCRNPDRELRPWCFTTD 249

  Fly   897 -----EVREVMRAATHPKCDG--FQC------------------------------DQNRCLPQE 924
                 |:.::.|..|.|...|  :||                              ..|| .|:.
Human   250 PNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNR-TPEN 313

  Fly   925 YVCDGHLD--------------CMDQADEAKCERCGPDEIYCGDSQCIGTKHICDG--------I 967
            :.|. :||              |.....:.:.|.|   :|...||..:.|:.:...        :
Human   314 FPCK-NLDENYCRNPDGKRAPWCHTTNSQVRWEYC---KIPSCDSSPVSTEQLAPTAPPELTPVV 374

  Fly   968 IDCPYGQDE------------RNCLRLSE-----------------------RNGDVGTGVLEVY 997
            .||.:|..:            :.|...|.                       ||.|...|.....
Human   375 QDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFT 439

  Fly   998 RIGQRQW----MPACVKNWDRAVSPSAVCSI----------------LGYSAVNATSV------- 1035
            .....:|    :..|.......|:|..|..:                .||....||:|
Human   440 TDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQD 504

  Fly  1036 -LTQLTHRPLLAT--VNVSTDIWKMYAKRKS---------TLMQEFANCKKTEDY-PMADLTCSN 1087
             ..|..||..:.|  .|....:.|.|.:...         |     .|.:|..|| .:......:
Human   505 WAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYT-----TNPRKLYDYCDVPQCAAPS 564

  Fly  1088 YECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI---LGGPEKIFYCAGVLISDQWVLTASHCV- 1148
            ::||:.:....|...|::||..|.|.:||:..::   .|    :.:|.|.|||.:|||||:||:
Human   565 FDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFG----MHFCGGTLISPEWVLTAAHCLE 625

  Fly  1149 -----GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRV 1208
                 .:|.||        ||..:..:.....|:::|..:...|.       ..||||.:|::..
Human   626 KSPRPSSYKVI--------LGAHQEVNLEPHVQEIEVSRLFLEPT-------RKDIALLKLSSPA 675

  Fly  1209 AFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTY-EYIVNEVQVPIITRNQCD--EW 1270
            ...:.::|.|||.|:. .:...|.|.:.|||     :.:.|: ..::.|.|:|:|....|:  |:
Human   676 VITDKVIPACLPSPNY-VVADRTECFITGWG-----ETQGTFGAGLLKEAQLPVIENKVCNRYEF 734

  Fly  1271 LDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYAN 1335
            | |..|....:|||...||.|:|||||||||:|   .||:::.:.|:.|||:.||.|..||||..
Human   735 L-NGRVQSTELCAGHLAGGTDSCQGDSGGPLVC---FEKDKYILQGVTSWGLGCARPNKPGVYVR 795

  Fly  1336 VVQYVPWIQ 1344
            |.::|.||:
Human   796 VSRFVTWIE 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	20/126 (16%)
		LDLa	911..942	CDD:238060	10/76 (13%)
		LDLa	945..979	CDD:238060	8/53 (15%)
		SR	980..>1034	CDD:214555	13/96 (14%)
		Tryp_SPc	1104..1346	CDD:238113	85/253 (34%)
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527	9/54 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527	14/87 (16%)
		KR	273..354	CDD:214527	12/85 (14%)
		KR	375..456	CDD:214527	11/80 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..416		2/19 (11%)
		KR	479..560	CDD:214527	17/85 (20%)
		Tryp_SPc	581..804	CDD:238113	84/251 (33%)