DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and C1ra

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_075632.3	Gene:	C1ra / 50909	MGIID:	1355313	Length:	707	Species:	Mus musculus

Alignment Length:	632	Identity:	155/632 - (24%)
Similarity:	225/632 - (35%)	Gaps:	179/632 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   801 NYIG------HFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTET 859
            ||:|      |.| .|.|.|..|.:|......|...|.::.:|..|:      ..||
Mouse   166 NYVGGYFCSCHPG-YELQKDGQSCQAECSSELYTEPSGYVSSLEYPQ------PYPP-------- 215

  Fly   860 MRRCGF-------------FFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCD 911
            ..||.:             |.|.|.:...:.::|..                 :.::...:.|..
Mouse   216 DLRCNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPY-----------------DQLQIYANGKNL 263

  Fly   912 GFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTK-HICDGIIDCPYGQ- 974
            |..|.:.| .|........:|.:...||:            |||:  |.| |.....|.||..:
Mouse   264 GEFCGKQR-PPDLDTSSNAVDLLFFTDES------------GDSR--GWKLHYTTETIKCPQPKA 313

  Fly   975 -DE---------------------RNCLRLSERNGDVGTGVLEVYRIGQRQ--W---MPAC-VKN 1011
             ||                     :...:|.|.|    ..:|....:.|..  |   ||.| :||
Mouse   314 LDEFTIIQDPQPQYQFRDYFIVTCKQGYQLMEGN----QALLSFTAVCQNDGTWHRAMPRCKIKN 374

  Fly  1012 WDRAVSPS----AVCSILGYSAVNATSVLTQLTHRP---LLATVNVSTDIWKMYAKRKSTLMQEF 1069
            ..:..|.|    ...:..|.:...|:  :....|.|   :|.....|..:..:|.   .|....:
Mouse   375 CGQPQSLSNGDFRYITTKGVTTYEAS--IQYHCHEPYYKMLTRAGSSESMRGIYT---CTAQGIW 434

  Fly  1070 ANCKKTEDYPMADLTCSNYECGRVKRGRHKP------SRRIIGGTQASPGNWPFLAAIL----GG 1124
            .|.::.|..|.....|.            ||      ..|||.|..|.|||:|:.|...    ||
Mouse   435 KNEEEGEKMPRCLPVCG------------KPVNPVTQKERIIRGQPARPGNFPWQAFTTTHGRGG 487

  Fly  1125 PEKIFYCAGVLISDQWVLTASHCV-----------GNYSVIDLEDWTIQLGVTRRNSFTYSGQKV 1178
                    |.|:.|:|:|||:|.:           .|..::      :.||.|........|..
Mouse   488 --------GALLGDRWILTAAHTIYPKHHNKENDNANPKML------VFLGHTNVEQIKKLGHH- 537

  Fly  1179 KVKAVIPHPQYNMAIAH--DNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKR 1241
            .|:.||.||.|.....:  :.||||.:|...|.....|||:|| |.:......|.:..|.|:|..
Mouse   538 PVRRVIIHPDYRQDEPNNFEGDIALLELENSVTLGPELLPICL-PDNETFYGQGLMGYVSGFGIT 601

  Fly  1242 EDKDPKSTYEYIVNEVQVPIITRNQCDEWL----DNLTVSEGMVCAGFDDGGKDACQGDSGGPLL 1302
            |||     ..:.:..|::|:.....|..||    |....|:.|.|:|.....:|||||||||...
Mouse   602 EDK-----LAFDLRFVRLPVADSEACQRWLQTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFA 661

  Fly  1303 CPYPGEKNR--WFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQI 1347
            .   .::||  |...|||||||.|....  |.|..|:.||.||::::
Mouse   662 V---RDRNRDIWVATGIVSWGIGCGEGY--GFYTKVLNYVDWIKKEM 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	22/111 (20%)
		LDLa	911..942	CDD:238060	7/30 (23%)
		LDLa	945..979	CDD:238060	11/57 (19%)
		SR	980..>1034	CDD:214555	15/63 (24%)
		SRCR	992..1086	CDD:278931	21/106 (20%)
		Tryp_SPc	1103..1343	CDD:214473	85/262 (32%)
		Tryp_SPc	1104..1346	CDD:238113	86/264 (33%)
C1ra	NP_075632.3	CUB	26..137	CDD:214483
		FXa_inhibition	160..188	CDD:291342	8/22 (36%)
		CUB	192..301	CDD:278839	25/154 (16%)
		Sushi	308..370	CDD:278512	12/65 (18%)
		CCP	375..446	CDD:153056	13/75 (17%)
		Tryp_SPc	462..699	CDD:214473	85/262 (32%)
		Tryp_SPc	463..701	CDD:238113	86/263 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910