DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and prss27

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_031749235.1	Gene:	prss27 / 496619	XenbaseID:	XB-GENE-5744470	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	728	Identity:	165/728 - (22%)
Similarity:	271/728 - (37%)	Gaps:	217/728 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   737 IAGGLAAYFNAYP-TIKFVNK-------TIINTIHVEDTT-SFGKNPAPGTCLPIIVRFC----Q 788
            |.||.:|....:| .:.|.|.       |:|:..:|.... .|..:.:..:...::..:.    .
Frog    34 IMGGQSAQEGQWPWQVSFRNNGGHFCGGTLISKQYVISAAHCFPSSSSASSVTAVLGAYMIDQPD 98

  Fly   789 GPQIP---YNYTVFPNYI--GHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGAT 848
            |.|:.   .:.|.:|:|:  |..|               |:...:|.|....|.::
Frog    99 GNQVAIPVQSATNYPSYVNEGDSG---------------DISLVQLASPVTFTNYI--------- 139

  Fly   849 VPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKL--FKDFPSSEDCVGLDEVREVMRAATHPKCD 911
            :|.|....|.|              .|..|.|.:  :.:..|....|....::||    ..|..|
Frog   140 LPVCLPADTVT--------------FPTGLQCWVTGWGNIASDVSLVSPMTLQEV----AVPLID 186

  Fly   912 GFQCDQNRCLPQEY-----------VCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKHICD 965
            ..:|:.....|..|           :|.|.::    ..:..|:         |||   |...:|.
Frog   187 ANECNALYQTPNSYGTSSISVHSDMICAGFIN----GGKDSCQ---------GDS---GGPLVCS 235

  Fly   966 --------GIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVC 1022
                    |::                   ..|.|..:.||.|....||: ..:|
Frog   236 SSGQWFLAGVV-------------------SFGEGCGQAYRPGVYTLMPS-YTDW---------- 270

  Fly  1023 SILGYSAVNATSVLTQLTHRPLLA-----TVNVST--DIW---------------KMYAKRKSTL 1065
             |:.|::..:::|.:.....|:::     |:.|||  ..|               .:||.....:
Frog   271 -IVSYASDASSNVKSATFSGPIISLNTAPTIAVSTLRISWVIILLYLLVRGLSKKPLYAMSLEFV 334

  Fly  1066 MQE--------------------------FANCKKTEDYP-------------------MADLTC 1085
            |.:                          |:..:..:..|                   :..|..
Frog   335 MSQGCCVSYPCVHYPTLLTWLCALHKQYHFSRAEGQKSLPSVTQLSLIGPMDPPSMMLRIISLLL 399

  Fly  1086 SNYECGRVKRGRHKP--SRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCV 1148
            :.:....:..|..:|  |.||:||..|..|.||:..:|:.....|  |.|.|:|..||::|:||.
Frog   400 AGFAVTAISTGCGQPAFSDRIVGGNNAVFGEWPWQVSIVYQNSHI--CGGSLVSSNWVVSAAHCF 462

  Fly  1149 -GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHE 1212
             .:|.:   |:..:.||.....:.|.....::||.||.:|.|. ......|||:.::.:.|.:..
Frog   463 PRSYKI---ENMQVLLGCFALMNLTSDAVIIRVKRVITYPLYT-GEGSSGDIAMVEMESPVTYSS 523

  Fly  1213 HLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEW------L 1271
            ::||:|:|..: .:...|.:|.|.|||..: .|...:..|.:.||:||::..:.||..      |
Frog   524 YILPICIPLTN-EDFPSGKMCWVTGWGNIQ-SDVSLSPPYPLQEVEVPLVNASSCDTMYHYNSDL 586

  Fly  1272 DNLT--VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYA 1334
            :..|  |.:.|:|||:.:|.||||||||||||.|.   ..|.||:.||||||..||.|..||||.
Frog   587 NPATQLVHDDMICAGYPEGQKDACQGDSGGPLACK---SGNYWFLTGIVSWGDGCAQPNRPGVYT 648

  Fly  1335 NVVQYVPWIQEQI 1347
            .|..:..||.:.:
Frog   649 KVSSFSSWINQYL 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	19/126 (15%)
		LDLa	911..942	CDD:238060	6/41 (15%)
		LDLa	945..979	CDD:238060	6/41 (15%)
		SR	980..>1034	CDD:214555	10/53 (19%)
		SRCR	992..1086	CDD:278931	22/160 (14%)
		Tryp_SPc	1103..1343	CDD:214473	90/248 (36%)
		Tryp_SPc	1104..1346	CDD:238113	91/250 (36%)
prss27	XP_031749235.1	Tryp_SPc	34..271	CDD:238113	55/325 (17%)
prss27	XP_031749235.1	Tryp_SPc	420..659	CDD:238113	91/249 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010