DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and tmprss2

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001008623.1	Gene:	tmprss2 / 494080	ZFINID:	ZDB-GENE-041212-48	Length:	486	Species:	Danio rerio

Alignment Length:	407	Identity:	117/407 - (28%)
Similarity:	179/407 - (43%)	Gaps:	73/407 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   954 DSQCIGTKHICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSP 1018
            |.:|:.....|||.:|||.|:||..|.||...|     .:|:.|......|...|...::..::.
Zfish   143 DKKCVSVSLWCDGTVDCPSGEDEAQCYRLYGPN-----FLLQKYSNVSANWKNVCSDGFNDNLAK 202

  Fly  1019 SAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADL 1083
            .| |:.:||.                        |.:..|....|..:...:.|:.:   ....|
Zfish   203 QA-CAEIGYK------------------------DTYSGYQGILSPSLDFISACQSS---TAVSL 239

  Fly  1084 TCSNYECGRVKRGRHKPSRRIIGGTQ-ASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHC 1147
            .|:  :|||      ....||:|||. .|.|.||:..::......:  |.|.:|:..|:|||:||
Zfish   240 KCT--DCGR------STGNRIVGGTTVTSKGVWPWQVSLHYSGRHL--CGGSIITPYWILTAAHC 294

  Fly  1148 VGNYSVIDLEDWTIQLG-VTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHD-------NDIALFQL 1204
            |..:|  :...||:..| :|:....:.||..|           |..:.||       |||||.:|
Zfish   295 VHQFS--NPGGWTVYAGYLTQSEMASASGNSV-----------NRIVIHDFNPNTNENDIALMRL 346

  Fly  1205 ATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDE 1269
            .|.:....::.|||||...: :......|.|.|||........|.   .:.|.::.:|....|:.
Zfish   347 NTALTISTNIRPVCLPNKGM-SFTAQQDCYVTGWGALFSGGSSSA---TLQEAKIQLIDSTICNS 407

  Fly  1270 W-LDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVY 1333
            . :.|..:::.|:|||...||.|:|||||||||:   ...::.|::.|..|||..||....||||
Zfish   408 RPVYNGLITDTMICAGKLAGGVDSCQGDSGGPLV---TNVRSLWWLLGDTSWGDGCAVRNKPGVY 469

  Fly  1334 ANVVQYVPWIQEQIAKH 1350
            .||..::.||.:|:.|:
Zfish   470 GNVTYFLDWIYQQMRKY 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060	11/24 (46%)
		SR	980..>1034	CDD:214555	11/53 (21%)
		SRCR	992..1086	CDD:278931	13/93 (14%)
		Tryp_SPc	1103..1343	CDD:214473	81/249 (33%)
		Tryp_SPc	1104..1346	CDD:238113	82/251 (33%)
tmprss2	NP_001008623.1	LDLa	132..168	CDD:238060	11/24 (46%)
		SRCR_2	173..248	CDD:295335	18/115 (16%)
		Tryp_SPc	251..479	CDD:214473	81/249 (33%)
		Tryp_SPc	252..482	CDD:238113	82/251 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910