Protein Alignment Corin and ACR

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001088.2
• Gene: ACR / 49
• HGNCID: 126
• Length: 421
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 98/287 - (34%)
• Similarity: 141/287 - (49%)
• Gaps: 36/287 - (12%)

  Fly  1084 TCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIF--------YCAGVLISDQW 1140
            ||.. .||...|...:...||:||..|..|.||::.::     :||        .|.|.|::.:|
Human    24 TCDG-PCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSL-----QIFTYNSHRYHTCGGSLLNSRW 82

  Fly  1141 VLTASHC-VGNYSVIDLEDWTIQLGVTRRNSFTYSGQK-VK-------VKAVIPHPQYNMAIAHD 1196
            ||||:|| ||..:|   .||.:..|.   ...||...| ||       |:.:|.|.:||.| ...
Human    83 VLTAAHCFVGKNNV---HDWRLVFGA---KEITYGNNKPVKAPLQERYVEKIIIHEKYNSA-TEG 140

  Fly  1197 NDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPI 1261
            |||||.::...::....:.|.|||............|.|.|||..|:|.|:.:  .|:.|.:|.:
Human   141 NDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPS--SILMEARVDL 203

  Fly  1262 ITRNQCD--EWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMC 1324
            |..:.|:  :|. |..|....||||:..|..|.|||||||||:|. ..:::.:.|.||.|||:.|
Human   204 IDLDLCNSTQWY-NGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCK-DSKESAYVVVGITSWGVGC 266

  Fly  1325 AHPRLPGVYANVVQYVPWIQEQIAKHS 1351
            |..:.||:|.....|:.||..:|..::
Human   267 ARAKRPGIYTATWPYLNWIASKIGSNA 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	91/260 (35%)
ACR	NP_001088.2	Tryp_SPc	42..285	CDD:214473	90/258 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..316
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..383
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421