Protein Alignment Corin and fz

DIOPT Version :9

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001261836.1
• Gene: fz / 45307
• FlyBaseID: FBgn0001085
• Length: 612
• Species: Drosophila melanogaster
• Alignment Length: 752
• Identity: 156/752 - (20%)
• Similarity: 239/752 - (31%)
• Gaps: 253/752 - (33%)

  Fly   751 IKFVNKTIINTIHVEDTTSFGKNP----------APGT----------CLPIIVRFCQGPQIPYN 795
            |.|:..|:|..:...|.:....:|          :.||          |.||.:..|:  .||||
  Fly     5 ILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICK--NIPYN 67

  Fly   796 YTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCGQSGATVPPCKTLCTETM 860
            .|:.||.|||..|.|...::..:..||.:.|.:.:.||||:|:||.|......:|||::|| |:.
  Fly    68 MTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLC-ESA 131

  Fly   861 RRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCV----------GLDEVREVMRAATHPKCDGFQC 915
            |.|......:..:.||.|.|..|......:.||          .....|.|.:..|.....|.:.
  Fly   132 RVCEKLMKTYNFNWPENLECSKFPVHGGEDLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVES 196

  Fly   916 DQNRCLPQEYVCDGHLDC-MDQADEAKCERCGPDEIYCGDSQCIGTKHICDGIIDCP---YGQDE 976
            .....   .:||...|.. :....|.|                :|.|.:.|....|.   :.:.|
  Fly   197 PHRNI---GFVCPVQLKTPLGMGYELK----------------VGGKDLHDCGAPCHAMFFPERE 242

  Fly   977 RNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNW-----------------DRAVSPSAVCSI 1024
            |..||               |.:|  .|...||.:.                 :||:...|||
  Fly   243 RTVLR---------------YWVG--SWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVC-- 288

  Fly  1025 LGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYE 1089
              |..|....|          |.:.....:                :|:  |.:|..
  Fly   289 --YLVVGCAYV----------AGLGAGDSV----------------SCR--EPFPPP-------- 315

  Fly  1090 CGRVKRGRHKPSRRII-GGTQASPGNWPFLAAILGGPEKIFYCAGV------LISDQWVLTAS-- 1145
               ||.||.:....|. |..|.:.....|:|        :::|...      .::..|.|.|.
  Fly   316 ---VKLGRLQMMSTITQGHRQTTSCTVLFMA--------LYFCCMAAFAWWSCLAFAWFLAAGLK 369

  Fly  1146 ---HCVGNYS-VIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAH-DNDIA----- 1200
               ..:.|.| :..|..|.:.           :.|.:.|          :|:|. :.||.
  Fly   370 WGHEAIENKSHLFHLVAWAVP-----------ALQTISV----------LALAKVEGDILSGVCF 413

  Fly  1201 LFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGW-------------GKREDKDPKSTYEY 1252
            :.||.|.......:||:|:      .|..|.|..:.|:             |||.||     .|.
  Fly   414 VGQLDTHSLGAFLILPLCI------YLSIGALFLLAGFISLFRIRTVMKTDGKRTDK-----LER 467

  Fly  1253 IVNEVQ-------VPIITRNQC--------DEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLL 1302
            ::..:.       :|.:....|        |||:              ....:|.|:..|   :.
  Fly   468 LMLRIGFFSGLFILPAVGLLGCLFYEYYNFDEWM--------------IQWHRDICKPFS---IP 515

  Fly  1303 CP---YPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQY-----VPW---IQEQIAKHSRPIKE 1356
            ||   .||......:..|.....:|:  .|.||.::|..|     |.|   ::....|..|...:
  Fly   516 CPAARAPGSPEARPIFQIFMVKYLCS--MLVGVTSSVWLYSSKTMVSWRNFVERLQGKEPRTRAQ 578

  Fly  1357 DRVNKYDLHPGGPDILSKIATDPMREGAPHHYTHSRT 1393
            ..| .|:..|.|....:.:..||  |.|...|....|
  Fly   579 AYV-XYETGPAGGAKSTPLTPDP--EAANESYLEFST 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	43/135 (32%)
		LDLa	911..942	CDD:238060	5/31 (16%)
		LDLa	945..979	CDD:238060	6/36 (17%)
		SR	980..>1034	CDD:214555	14/70 (20%)
		SRCR	992..1086	CDD:278931	17/110 (15%)
		Tryp_SPc	1103..1343	CDD:214473	56/297 (19%)
		Tryp_SPc	1104..1346	CDD:238113	56/299 (19%)
fz	NP_001261836.1	CRD_FZ1_like	51..167	CDD:143567	42/118 (36%)
		Frizzled	237..564	CDD:279827	81/445 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810