Protein Alignment Corin and Tmprss9

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_006513905.2
• Gene: Tmprss9 / 432478
• MGIID: 3612246
• Length: 1342
• Species: Mus musculus
• Alignment Length: 1029
• Identity: 232/1029 - (22%)
• Similarity: 341/1029 - (33%)
• Gaps: 385/1029 - (37%)

  Fly   635 LLPSLSAKR-LCSAPAPIVCRQG-----------------VQHEPIEELEPPQTISPLHKAAGQP 681
            |||.|.|:. ||.|.|.....||                 ..|.|:    |||   |..:..||.
Mouse    91 LLPQLPAESPLCEAQAAHPAHQGSTVVGRPRLDPRFPLYRCGHRPL----PPQ---PWLQLMGQV 148

  Fly   682 SSLQTIVRFQNGAPHTM----------------SLQHQIINRRKSSNPYITNGRLKFRLFQILIN 730
            ..|:|  |:.....|..                |||.|:    .|.:|      :..:|.:
Mouse   149 PDLKT--RWFGVCGHLRGWYPAQVTPTCGKPRPSLQAQL----SSGSP------VSLKLCE---- 197

  Fly   731 AFALLAIAGGLAAYFNAY---------PTIKFVNKTIINTIHVEDTTSFGKNPAPGTC------- 779
              |||....|......||         |.::.|.: :...:.|       ..|.||.|
Mouse   198 --ALLCWKAGTWCLAGAYLCRAMEPTAPDLQLVPE-VTKAVSV-------SAPDPGPCRTAVIAV 252

  Fly   780 ---------LPIIVRF--CQGPQIPYNYTVFPNYIGHFGQLE--------TQTDLDSYEALVDVR 825
                     |.::..|  .||.           ::.|..:|.        .|.:.|.|..|.
Mouse   253 VGISMAIVTLGVLSAFFSAQGA-----------HVEHIAELHGIRFTSSLQQENSDFYRLLT--- 303

  Fly   826 CYELVSLFL--------------CTLFVPKCGQSGATVPPCKTLCTETMRRCGFFF--------- 867
             :.|.:||:              ||:...:.|.|...|          ..|..|..
Mouse   304 -HALQTLFVSSFQKTELESSCAGCTVLSYRDGNSTVIV----------HFRLHFLLRALQPLSLK 357

  Fly   868 ---DVF-----------GLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDG--FQCD 916
               |:.           ||||..|...       .|.:..|..|.....|......|.|  |.|.
Mouse   358 QEADILQKGIQARLQEQGLSLAAYGTI-------VSVELTGRCEGPVTERDLKSGHCPGNVFSCQ 415

  Fly   917 QNRCLPQEY-VCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIG------------------TKH 962
            ..:|:.:|. .||..:||.|::|||:|: ||....:....:.:|                  .:|
Mouse   416 NGQCVSKENPECDDRVDCSDESDEAQCD-CGWQPAWRSAGRIVGGVEAAPGEFPWQVSLRENHEH 479

  Fly   963 ICDG-IIDCPYGQDERNC-------------------------------LRLSER------NGDV 989
            .|.. ||...:.....:|                               ||:::.      ..|.
Mouse   480 FCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRTRVLRIAKHPAYDADTADF 544

  Fly   990 GTGVLEVYR---IGQRQWMPACVKNWDRAVSPSAVCSILGYSAVN-------------ATSVLTQ 1038
            ...|||:.|   .| |...|||:........|...|.|.|:..:.             ...:|.|
Mouse   545 DVAVLELARPLPFG-RYVQPACLPAATHVFPPGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQ 608

  Fly  1039 ----------LTHR--------------------PL----------LATVNVSTDIWKMYAKR-- 1061
                      ||.|                    ||          ||.: ||..|....|:|
Mouse   609 SLCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGI-VSWGIGCAEARRPG 672

  Fly  1062 ---KSTLMQEF-ANCKKTEDYPMA----------------------------------------D 1082
               :.|.:::: .......|.|:.                                        .
Mouse   673 VYTRVTRLRDWILEVTSAADMPVVPTATPAPATPSTPWPTSPESWAPNTFAKPTAAPSPVPLHPS 737

  Fly  1083 LTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHC 1147
            .|....||| .:....||: ||:||..|..|..|:.|::..||.  .:|...::.|:|:|:|:||
Mouse   738 TTAKPQECG-ARPAMDKPT-RIVGGISAVSGEVPWQASLKEGPR--HFCGATVVGDRWLLSAAHC 798

  Fly  1148 VGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHE 1212
            ..:..|   |.....||.........|..|:.::.|..||:||..|. |.|:||.:||..:.|::
Mouse   799 FNHTKV---EQVQAHLGTVSLLGVGGSPVKLGLRRVALHPRYNPGIL-DFDVALLELAQPLVFNK 859

  Fly  1213 HLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVS 1277
            ::.|||| |.::.....|..|.:.|||..::.:  :|...|:.:..|.||.:..|.. |.|.:::
Mouse   860 YIQPVCL-PLAIHKFPVGRKCMISGWGNMQEGN--ATKPDILQKASVGIIEQKMCGA-LYNFSLT 920

  Fly  1278 EGMVCAGFDDGGKDACQGDSGGPLLC-PYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVP 1341
            :.|:||||.:|..|:|||||||||.| ..||.   :::.|||||||.||..:.|||||.:.:...
Mouse   921 DRMLCAGFLEGRVDSCQGDSGGPLACEETPGV---FYLAGIVSWGIGCAQAKKPGVYARITRLKD 982

  Fly  1342 WIQEQIAKHSRPIKEDRVNKYDLHPGGPDILSKIATDPMREGAPHHYTHSRTSS 1395
            |                            ||..:::||.....||      |||
Mouse   983 W----------------------------ILKAMSSDPSSMARPH------TSS 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	28/178 (16%)
		LDLa	911..942	CDD:238060	13/33 (39%)
		LDLa	945..979	CDD:238060	7/52 (13%)
		SR	980..>1034	CDD:214555	16/75 (21%)
		Tryp_SPc	1104..1346	CDD:238113	87/242 (36%)
Tmprss9	XP_006513905.2	SEA	285..365	CDD:460188	15/93 (16%)
		LDLa	407..442	CDD:238060	14/34 (41%)
		Tryp_SPc	455..684	CDD:214473	37/230 (16%)
		Tryp_SPc	756..984	CDD:214473	88/268 (33%)
		Tryp_SPc	1085..1336	CDD:238113