DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Sb

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001287355.1	Gene:	Sb / 41958	FlyBaseID:	FBgn0003319	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	107/371 - (28%)
Similarity:	169/371 - (45%)	Gaps:	90/371 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1014 RAVSPSAVCSILGYSAVNATSVLTQLTHR-PLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTED 1077
            |.:|.|:..|   ...|.::...||.||| |:|||..:.|:                    :..|
  Fly   469 RPISSSSSSS---SGIVTSSQRPTQPTHRTPVLATSGIETN--------------------EISD 510

  Fly  1078 YPMAD---------LTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI----LGGPEKIF 1129
            ..:.|         ::.:..|||.....|  |..||:||..|:.|.||:..::    ..|.....
  Fly   511 SSIPDAGALGHVKTISAARSECGVPTLAR--PETRIVGGKSAAFGRWPWQVSVRRTSFFGFSSTH 573

  Fly  1130 YCAGVLISDQWVLTASHC------------VGNYSVIDLEDWT--IQLGVTRRNSFTYSGQKVKV 1180
            .|.|.||::.|:.||.||            ||.|....:::..  |:.||.::
  Fly   574 RCGGALINENWIATAGHCVDDLLISQIRIRVGEYDFSHVQEQLPYIERGVAKK------------ 626

  Fly  1181 KAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKD 1245
               :.||:|:. :.::.|:||.:|...:.|..|:.|:||  |...:|..|...||.|||:..:
  Fly   627 ---VVHPKYSF-LTYEYDLALVKLEQPLEFAPHVSPICL--PETDSLLIGMNATVTGWGRLSE-- 683

  Fly  1246 PKSTYEYIVNEVQVPIITRNQC---------DEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPL 1301
             ..|...::.||.|||::.:.|         .|::.::     .:|||::.||:|:|||||||||
  Fly   684 -GGTLPSVLQEVSVPIVSNDNCKSMFMRAGRQEFIPDI-----FLCAGYETGGQDSCQGDSGGPL 742

  Fly  1302 LCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQI 1347
            ..  ..:..|:|:.||:||||.||...||||...:.::.|||.|.:
  Fly   743 QA--KSQDGRFFLAGIISWGIGCAEANLPGVCTRISKFTPWILEHV 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	5/19 (26%)
		SRCR	992..1086	CDD:278931	17/81 (21%)
		Tryp_SPc	1103..1343	CDD:214473	82/266 (31%)
		Tryp_SPc	1104..1346	CDD:238113	83/268 (31%)
Sb	NP_001287355.1	Tryp_SPc	543..782	CDD:214473	82/266 (31%)
Sb	NP_001287355.1	Tryp_SPc	544..785	CDD:238113	83/268 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010