DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and ovch1

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_956439.2	Gene:	ovch1 / 393114	ZFINID:	ZDB-GENE-040426-834	Length:	556	Species:	Danio rerio

Alignment Length:	296	Identity:	92/296 - (31%)
Similarity:	143/296 - (48%)	Gaps:	41/296 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1072 CKK-------TEDYPMADLTCSNYE--------CGRVKRGR------HKPSRRIIGGTQASPGNW 1115
            |||       |..:..||...|::|        |..:...|      .....|||||.:|...:|
Zfish     4 CKKCLFILILTLKWTKADSDASSFETDCILDKGCDVLAGIRSFVPEDEVEESRIIGGKEAWAHSW 68

  Fly  1116 PFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGV-TRRNSFTYSGQKVK 1179
            |:..::  ....:..|.|.::...||:||.||...|....:  |...:|: ...|:...|.:.::
Zfish    69 PWQVSL--QYNDVPTCGGAILDQLWVITAGHCFKRYKKPSM--WNAVVGLHNLDNANESSRESIQ 129

  Fly  1180 VKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRN--LHPGTLCTVIGWGKRE 1242
            |:.:..|..||.. .::|||||.:|.:.:.|.:.:.|:     .|.|  |.|...|||.|||...
Zfish   130 VQKIFSHKNYNQK-TNENDIALLKLQSPLVFSKFVRPI-----GVFNNDLPPLVTCTVTGWGSVT 188

  Fly  1243 DKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPG 1307
            :..|:::.   :.||.|.:....:|:.:... .|.:.|:|||.::||.|||||||||||.| :.|
Zfish   189 ENGPQASR---LQEVNVTVYEPQKCNRFYRG-KVLKSMICAGANEGGMDACQGDSGGPLSC-FDG 248

  Fly  1308 EKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWI 1343
            |  |:.:.|:||||:.|...:.||||..:..|..|:
Zfish   249 E--RYKLAGVVSWGVGCGRAQKPGVYTTLYHYRQWM 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931	6/20 (30%)
		Tryp_SPc	1103..1343	CDD:214473	81/242 (33%)
		Tryp_SPc	1104..1346	CDD:238113	81/243 (33%)
ovch1	NP_956439.2	Tryp_SPc	56..281	CDD:214473	81/241 (34%)
		Tryp_SPc	57..281	CDD:238113	80/240 (33%)
		Tryp_SPc	331..551	CDD:238113
		Tryp_SPc	331..549	CDD:214473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910