DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and CG6462

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_648011.1	Gene:	CG6462 / 38681	FlyBaseID:	FBgn0035663	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	359	Identity:	99/359 - (27%)
Similarity:	152/359 - (42%)	Gaps:	83/359 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1027 YSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCK-KTED------------- 1077
            |.|.:|..:|.      |.:|:..|::.|          :..|.:.| :|.|
  Fly     4 YQATSAFFLLL------LSSTLVKSSEPW----------LDTFEHPKEETPDDDDAIMERRWQLG 52

  Fly  1078 YPMADLTCSNYECGRVKRGRHKPS--RRIIGGTQASPGNWPF---LAAILGGPEKIFYCAGVLIS 1137
            |....|.|..:|    ..|....:  .||.||..|:.|.:|:   |...|.|.: :..|.|.||:
  Fly    53 YENFRLRCEKFE----MEGNQTAAVRTRIAGGELATRGMFPYQVGLVIQLSGAD-LVKCGGSLIT 112

  Fly  1138 DQWVLTASHCV----------GNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMA 1192
            .|:||||:||:          |.....|:||...:|.||.|:...|             |.| :.
  Fly   113 LQFVLTAAHCLTDAIAAKIYTGATVFADVEDSVEELQVTHRDFIIY-------------PDY-LG 163

  Fly  1193 IAHDNDIALFQLATRVAFHEHLLPVCLPPPSV-RNLHPGTLCTVIGWGKREDKDPKST--YEYIV 1254
            ....:|:||.:|..:|...|.:.|:.|....: :|...|.:.|:.|||...|...|.|  .:|:.
  Fly   164 FGGYSDLALIRLPRKVRTSEQVQPIELAGEFMHQNFLVGKVVTLSGWGYLGDSTDKRTRLLQYLD 228

  Fly  1255 NEVQVPIITRNQC-DEWLDNLTVSEGMVCAGFDDG--GKDACQGDSGGPLLCPYPGEKNRWFVGG 1316
            .||    |.:.:| ..:|..|......:|.   ||  |:.||.||||||::..:   :|..::.|
  Fly   229 AEV----IDQERCICYFLPGLVSQRRHLCT---DGSNGRGACNGDSGGPVVYHW---RNVSYLIG 283

  Fly  1317 IVSWGIM--CAHPRLPGVYANVVQYVPWIQEQIA 1348
            :.|:|..  | ....|.||..:..|:|||::|.|
  Fly   284 VTSFGSAEGC-EVGGPTVYTRITAYLPWIRQQTA 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555	3/6 (50%)
		SRCR	992..1086	CDD:278931	14/72 (19%)
		Tryp_SPc	1103..1343	CDD:214473	78/260 (30%)
		Tryp_SPc	1104..1346	CDD:238113	79/262 (30%)
CG6462	NP_648011.1	Tryp_SPc	76..311	CDD:214473	78/260 (30%)
CG6462	NP_648011.1	Tryp_SPc	77..314	CDD:238113	79/262 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010