Protein Alignment Corin and KLK1

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Alignment Length: 279
• Identity: 85/279 - (30%)
• Similarity: 130/279 - (46%)
• Gaps: 60/279 - (21%)

  Fly  1105 IGGTQASPGNWPFLAAILGGPE---------------KIFYCAGVLISDQWVLTASHCVG-NYSV 1153
            :|||.|:|   |..:.|:||.|               ..|.|.|:|:..||||||:||:. ||
Human    12 LGGTGAAP---PIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNY-- 71

  Fly  1154 IDLEDWTIQLGVTRRNSF--TYSGQKVKVKAVIPHPQYNMAIA----------HDNDIALFQL-- 1204
                    ||.:.|.|.|  ..:.|.|.|....|||.:||::.          :.:|:.|.:|
Human    72 --------QLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTE 128

  Fly  1205 -ATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCD 1268
             |..:.....::.:....|.|     |:.|...|||..|.::  .::...:..|.:.|:..::|.
Human   129 PADTITDAVKVVELPTEEPEV-----GSTCLASGWGSIEPEN--FSFPDDLQCVDLKILPNDECK 186

  Fly  1269 EWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWG-IMCAHPRLPGV 1332
            : .....|::.|:|.|..:||||.|.|||||||:|.       ..:.|:.||| :.|..|..|.|
Human   187 K-AHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCD-------GVLQGVTSWGYVPCGTPNKPSV 243

  Fly  1333 YANVVQYVPWIQEQIAKHS 1351
            ...|:.||.||::.||::|
Human   244 AVRVLSYVKWIEDTIAENS 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	82/272 (30%)
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	76/256 (30%)