DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and PRSS41

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001382429.1	Gene:	PRSS41 / 360226	HGNCID:	30715	Length:	334	Species:	Homo sapiens

Alignment Length:	275	Identity:	93/275 - (33%)
Similarity:	143/275 - (52%)	Gaps:	30/275 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1090 CGRVKRGRHKPSRRII-GGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSV 1153
            ||      |:....:: ||.:::.|.||:.|::  ...:...|.|.|:|.:|||:|:||...:..
Human    62 CG------HREIHALVAGGVESARGRWPWQASL--RLRRRHRCGGSLLSRRWVLSAAHCFQKHYY 118

  Fly  1154 IDLEDWTIQLG-VTRR----NSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEH 1213
              ..:||:||| :|.|    |...|| .:.||:.:|.:|.....:.  |||||.:||:.|.::.:
Human   119 --PSEWTVQLGELTSRPTPWNLRAYS-SRYKVQDIIVNPDALGVLR--NDIALLRLASSVTYNAY 178

  Fly  1214 LLPVCLPPPSVRNLH-PGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLT-- 1275
            :.|:|:...:...:| |.  |.|.|||............|.:.|.||.|:...:|:...:..:
Human   179 IQPICIESSTFNFVHRPD--CWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYLFEQPSSR 241

  Fly  1276 --VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQ 1338
              :.:.|.|||.:||..|.|:|||||||:|...|   .|:..||||||:.|..|..||||.|:..
Human   242 SMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDG---LWYQVGIVSWGMDCGQPNRPGVYTNISV 303

  Fly  1339 YVPWIQEQIAKHSRP 1353
            |..||: ::..||.|
Human   304 YFHWIR-RVMSHSTP 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		SRCR	992..1086	CDD:278931
		Tryp_SPc	1103..1343	CDD:214473	85/250 (34%)
		Tryp_SPc	1104..1346	CDD:238113	87/252 (35%)
PRSS41	NP_001382429.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010