Protein Alignment Corin and KLK3

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001639.1
• Gene: KLK3 / 354
• HGNCID: 6364
• Length: 261
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 87/266 - (32%)
• Similarity: 127/266 - (47%)
• Gaps: 53/266 - (19%)

  Fly  1103 RIIGGTQASPGN--WPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGV 1165
            ||:||.:....:  |..|.|..|..    .|.|||:..||||||:||:.|.||       |.||
Human    24 RIVGGWECEKHSQPWQVLVASRGRA----VCGGVLVHPQWVLTAAHCIRNKSV-------ILLG- 76

  Fly  1166 TRRNSFTY---SGQKVKVKAVIPHPQYNMAIAHD----------NDIALFQLATRVAFHEHLLPV 1217
              |:|..:   :||..:|....|||.|:|::..:          :|:.|.:|:......:.:..:
Human    77 --RHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHDLMLLRLSEPAELTDAVKVM 139

  Fly  1218 CLP--PPSVRNLHPGTLCTVIGWGKREDKD---PKSTYEYIVNEVQVPIITRNQCDEWLDNLTVS 1277
            .||  .|::     ||.|...|||..|.::   ||.     :..|.:.:|:.:.|.: :....|:
Human   140 DLPTQEPAL-----GTTCYASGWGSIEPEEFLTPKK-----LQCVDLHVISNDVCAQ-VHPQKVT 193

  Fly  1278 EGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGI-MCAHPRLPGVYANVVQYVP 1341
            :.|:|||...|||..|.|||||||:|       ...:.||.|||. .||.|..|.:|..||.|..
Human   194 KFMLCAGRWTGGKSTCSGDSGGPLVC-------NGVLQGITSWGSEPCALPERPSLYTKVVHYRK 251

  Fly  1342 WIQEQI 1347
            ||::.|
Human   252 WIKDTI 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060
		SR	980..>1034	CDD:214555
		Tryp_SPc	1104..1346	CDD:238113	85/262 (32%)
KLK3	NP_001639.1	Tryp_SPc	25..256	CDD:238113	85/262 (32%)