DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	656	Identity:	167/656 - (25%)
Similarity:	243/656 - (37%)	Gaps:	216/656 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   740 GLAAYFNAYPTIKFVNKTIINTIHVEDTTSF-GKNPAPG-------------------TCLPIIV 784
            |:.|||...|..|     ..||:.|:|.|.| ||..:|.                   :.|.|.:
Human   352 GIRAYFEVIPEQK-----CENTVLVKDITGFEGKISSPYYPSYYPPKCKCTWKFQTSLSTLGIAL 411

  Fly   785 RFCQGPQIPYNYTVFPN----------------YIGHFGQLETQTDLDSYEALVDVRCYELVSLF 833
            :|       |||::...                |.|.:...:|...:.|....:.::|...:|
Human   412 KF-------YNYSITKKSMKGCEHGWWEINEHMYCGSYMDHQTIFRVPSPLVHIQLQCSSRLS-- 467

  Fly   834 LCTLFVPKCGQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDC-VGLDE 897
                              .|.|..|                        :..:..|:.| ||
Human   468 ------------------DKPLLAE------------------------YGSYNISQPCPVG--- 487

  Fly   898 VREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIYCGDSQCIGTKH 962
                          .|:|....|:||...|||..||.|::||..|....|   .|..|..  .:|
Human   488 --------------SFRCSSGLCVPQAQRCDGVNDCFDESDELFCVSPQP---ACNTSSF--RQH 533

  Fly   963 ---ICDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSI 1024
               ||||..||..|:||:||                                     :.|..|:
Human   534 GPLICDGFRDCENGRDEQNC-------------------------------------TQSIPCN- 560

  Fly  1025 LGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYP--MADLTCSN 1087
                            :|    |.....||         ...::.|.|..|.|.|  ..:..|:
Human   561 ----------------NR----TFKCGNDI---------CFRKQNAKCDGTVDCPDGSDEEGCT- 595

  Fly  1088 YECGRVKRGRHKPSRRIIGGTQASPGNWPFLAAI--LGGPEKIFYCAGVLISDQWVLTASHCVGN 1150
              |.|.....|    ||||||....|.||:..::  :|..    ||...:||.:|:|:|:||...
Human   596 --CSRSSSALH----RIIGGTDTLEGGWPWQVSLHFVGSA----YCGASVISREWLLSAAHCFHG 650

  Fly  1151 YSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHL- 1214
            ..:.|...||..||:..:.:..:..   .|:.::.|..|| :...|.||||.||:  :|:.|.|
Human   651 NRLSDPTPWTAHLGMYVQGNAKFVS---PVRRIVVHEYYN-SQTFDYDIALLQLS--IAWPETLK 709

  Fly  1215 ---LPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNLTV 1276
               .|:|:||...| :..|..|.|.|||:|.:.|.|.:  .::.:.:|.:|.:..|......:|
Human   710 QLIQPICIPPTGQR-VRSGEKCWVTGWGRRHEADNKGS--LVLQQAEVELIDQTLCVSTYGIIT- 770

  Fly  1277 SEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVP 1341
             ..|:|||...|.:|||:|||||||.|....: .:|.:.||||||.....|..||||..|..:||
Human   771 -SRMLCAGIMSGKRDACKGDSGGPLSCRRKSD-GKWILTGIVSWGHGSGRPNFPGVYTRVSNFVP 833

  Fly  1342 WIQEQI 1347
            ||.:.:
Human   834 WIHKYV 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	17/132 (13%)
		LDLa	911..942	CDD:238060	13/30 (43%)
		LDLa	945..979	CDD:238060	13/36 (36%)
		SR	980..>1034	CDD:214555	2/53 (4%)
		SRCR	992..1086	CDD:278931	11/95 (12%)
		Tryp_SPc	1103..1343	CDD:214473	87/245 (36%)
		Tryp_SPc	1104..1346	CDD:238113	88/247 (36%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910