Protein Alignment Corin and OVCH1

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_024304736.1
• Gene: OVCH1 / 341350
• HGNCID: 23080
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 437
• Identity: 124/437 - (28%)
• Similarity: 197/437 - (45%)
• Gaps: 85/437 - (19%)

  Fly   952 CGDSQCI---GTKHI------------CDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQ 1001
            ||....:   ||.|.            |...|..|    |::.::|:          .|.:.:
Human   454 CGSLAILVEEGTNHSAKYPDLYPSNTRCHWFICAP----EKHIIKLT----------FEDFAV-- 502

  Fly  1002 RQWMPACVKNWDRAVSPSAVCSILGYSAV--NATSVLTQLTHRPLLATVNVSTDIWKMYAKRK-- 1062
             ::.|.|:  :|..|       |.|.|..  ....:...||...:.::.|::...:|...|.:
Human   503 -KFSPNCI--YDAVV-------IYGDSEEKHKLAKLCGMLTITSIFSSSNMTVIYFKSDGKNRLQ 557

  Fly  1063 ----------STLMQEFANCKKTEDYPMADLTCSNYE-CGRVKRGRHKPSRRIIGGTQASPGNWP 1116
                      |..:.:|......::.|::.:....:: ||.........||||.||.:|.|..||
Human   558 GFKARFTILPSESLNKFEPKLPPQNNPVSTVKAILHDVCGIPPFSPQWLSRRIAGGEEACPHCWP 622

  Fly  1117 FLAAI--LGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLED----WTIQLGVTRRNSFTYSG 1175
            :...:  ||.    :.|.|.:|:..|:|||:|||      .|::    |||..|...||....:.
Human   623 WQVGLRFLGD----YQCGGAIINPVWILTAAHCV------QLKNNPLSWTIIAGDHDRNLKESTE 677

  Fly  1176 QKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGK 1240
            |..:.|.:|.|..:| .:::|:||||.||::.:.::..:.|||| |.|...|....:|.|.|||.
Human   678 QVRRAKHIIVHEDFN-TLSYDSDIALIQLSSPLEYNSVVRPVCL-PHSAEPLFSSEICAVTGWGS 740

  Fly  1241 -REDKDPKSTYEYIVNEVQVPIITRNQCDEWLDNL---TVSEGMVCAGF-DDGGKDACQGDSGGP 1300
             ..|....|.    :.::||.::.|..|:....:.   .::|.|:|||| ..|.||.||||||||
Human   741 ISADGGLASR----LQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFAASGEKDFCQGDSGGP 801

  Fly  1301 LLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQI 1347
            |:|.:  |...:.:.||||||..|..|..|||:|.|:.::.|||.:|
Human   802 LVCRH--ENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSKI 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060	9/41 (22%)
		SR	980..>1034	CDD:214555	9/55 (16%)
		Tryp_SPc	1104..1346	CDD:238113	92/252 (37%)
OVCH1	XP_024304736.1	Tryp_SPc	58..294	CDD:238113
		CUB	336..444	CDD:238001
		CUB	454..565	CDD:238001	23/136 (17%)
		Tryp_SPc	610..845	CDD:238113	92/252 (37%)
		CUB	881..978	CDD:238001
		CUB	1017..1119	CDD:238001