DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Tmprss6

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_006242057.1	Gene:	Tmprss6 / 315388	RGDID:	1307138	Length:	811	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	145/486 - (29%)
Similarity:	196/486 - (40%)	Gaps:	144/486 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   865 FFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCDGFQC-DQNRCLPQEYVCD 928
            |...|.||.:|.   |...||.|:     ||||...|.||.       ||| :.:.|:....|||
  Rat   462 FLCSVNGLCVPA---CDGIKDCPN-----GLDERNCVCRAM-------FQCQEDSTCISLPRVCD 511

  Fly   929 GHLDCMDQADEAKCER---CGPDEIYCGDSQCIGTKH-ICDGIIDCPYGQDERNCLRLSERNGDV 989
            ...||::.:||.:|:.   ||.....|.|..|:...: .|||..||..|.||.:|
  Rat   512 RQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQADCRDGSDEEHC---------- 566

  Fly   990 GTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDI 1054

  Rat   567 ----------------------------------------------------------------- 566

  Fly  1055 WKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLA 1119
                                              :|     |...||.||:||..:|.|.||:.|
  Rat   567 ----------------------------------DC-----GLQGPSSRIVGGAMSSEGEWPWQA 592

  Fly  1120 AILGGPEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVI 1184
            ::......|  |.|.||:|:||:||:||....|:.....||:.||..|:||........||..:.
  Rat   593 SLQIRGRHI--CGGALIADRWVITAAHCFQEDSMASPRLWTVFLGKMRQNSRWPGEVSFKVSRLF 655

  Fly  1185 PHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPKST 1249
            .|| |:...:||.|:||.||...|.:...:.|||||..| ....||..|.:.|||.:.:..|.|:
  Rat   656 LHP-YHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARS-HFFEPGQHCWITGWGAQREGGPGSS 718

  Fly  1250 YEYIVNEVQVPIITRNQCDEWLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFV 1314
               .:.:|.|.:|.::.|:| .....|:..|:|||:..|.||||||||||||:|..|  ..|||:
  Rat   719 ---TLQKVDVQLIPQDLCNE-AYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKEP--SGRWFL 777

  Fly  1315 GGIVSWGIMCAHPRLPGVYANVVQYVPWIQE 1345
            .|:||||:.|..|...|||..|.:.|.|||:
  Rat   778 AGLVSWGLGCGRPNFFGVYTRVTRVVNWIQQ 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	9/28 (32%)
		LDLa	911..942	CDD:238060	11/31 (35%)
		LDLa	945..979	CDD:238060	13/34 (38%)
		SR	980..>1034	CDD:214555	0/53 (0%)
		SRCR	992..1086	CDD:278931	0/93 (0%)
		Tryp_SPc	1103..1343	CDD:214473	96/239 (40%)
		Tryp_SPc	1104..1346	CDD:238113	98/242 (40%)
Tmprss6	XP_006242057.1	SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060	13/34 (38%)
		LDLa	495..525	CDD:238060	11/29 (38%)
		Ldl_recept_a	529..566	CDD:278486	13/36 (36%)
		Tryp_SPc	576..806	CDD:214473	96/239 (40%)
		Tryp_SPc	577..809	CDD:238113	98/242 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910