Protein Alignment Corin and HGFAC

DIOPT Version :10

• Sequence 1: NP_610297.2
• Gene: Corin / 35691
• FlyBaseID: FBgn0033192
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001284368.1
• Gene: HGFAC / 3083
• HGNCID: 4894
• Length: 662
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 166/628 - (26%)
• Similarity: 232/628 - (36%)
• Gaps: 170/628 - (27%)

  Fly   844 QSGATVPPCKTL----------CTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEV 898
            |||...||.:.:          .||..|.|.|.|...|..|               ..|......
Human    79 QSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRML---------------HACTSEGSA 128

  Fly   899 REVMRAATH----PKCDGF---------------QCDQNRCL----------PQEYVCD------ 928
            .....|.||    .:..|:               .|....||          ||.|.|.
Human   129 HRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFT 193

  Fly   929 ----GHLDCMDQ--------------ADEAKCERCGPDEIYCGDSQCIGTKH------------- 962
                |...|.|:              ..:...|:|   |.:.|.:.|.||:|
Human   194 GKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQC---ECFGGRTWCEGTRHTACLSSPCLNGGT 255

  Fly   963 ----ICDG--IIDCPYGQDERNC-LRLSER----NGDVGTGVLEVYRIGQRQWMPACVKNWDRAV 1016
                :..|  :..||.|...|.| :...||    ||....||......|.     :|:     |.
Human   256 CHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGL-----SCL-----AW 310

  Fly  1017 SPSAVCSILGYSAVNATSVLTQLTH----------RPLLATVNVSTDIWKMYAKRKSTLMQEFAN 1071
            :...:...|...:|.|.::|....|          ||....|..|...|: |.:.::..::....
Human   311 NSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWE-YCRLEACDLETEGR 374

  Fly  1072 CKKTEDYPMADLTCSNYE--------CGRVKRGRHKPSR----RIIGGTQASPGNWPFLAAILGG 1124
            ...|......||..:..|        |||    |||...    |||||:.:.||:.|:||||..|
Human   375 ESLTRVQLSPDLLATLPEPASPGRQACGR----RHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIG 435

  Fly  1125 PEKIFYCAGVLISDQWVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQY 1189
            ..   :|||.|:...||::|:||..:....|  ..::.||....|..|...|...::..||:..|
Human   436 DS---FCAGSLVHTCWVVSAAHCFSHSPPRD--SVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLY 495

  Fly  1190 NMAIAHDNDIALFQL-------ATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDKDPK 1247
            ::....|:|:.|.:|       |||..|   :.|:|||.|. .....|..|.:.|||..::.  .
Human   496 SVFNPSDHDLVLIRLKKKGDRCATRSQF---VQPICLPEPG-STFPAGHKCQIAGWGHLDEN--V 554

  Fly  1248 STYEYIVNEVQVPIITRNQCDE-WLDNLTVSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNR 1311
            |.|...:.|..||::..::|.. .:....:|..|:|||:.|...|||||||||||.|    |||.
Human   555 SGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLAC----EKNG 615

  Fly  1312 -WFVGGIVSWGIMCAHPRLPGVYANVVQYVPWIQEQIAKHSRP 1353
             .::.||:|||..|.....||||..|..||.||.::|    ||
Human   616 VAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRI----RP 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	14/59 (24%)
		LDLa	911..942	CDD:238060	11/79 (14%)
		LDLa	945..979	CDD:238060	12/52 (23%)
		SR	980..>1034	CDD:214555	12/57 (21%)
		Tryp_SPc	1104..1346	CDD:238113	90/250 (36%)
HGFAC	NP_001284368.1	PRK14954	<32..>100	CDD:184918	5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..102		5/22 (23%)
		FN2	102..148	CDD:128373	13/60 (22%)
		EGF_CA	162..197	CDD:238011	7/34 (21%)
		FN1	200..240	CDD:238018	7/42 (17%)
		EGF_CA	245..278	CDD:238011	5/32 (16%)
		Kringle	286..367	CDD:395005	18/91 (20%)
		Tryp_SPc	415..650	CDD:238113	90/249 (36%)