DRSC/TRiP Functional Genomics Resources

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Protein Alignment Corin and fzd5

DIOPT Version :10

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_571209.2 Gene:fzd5 / 30364 ZFINID:ZDB-GENE-990415-218 Length:592 Species:Danio rerio


Alignment Length:546 Identity:111/546 - (20%)
Similarity:166/546 - (30%) Gaps:231/546 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   779 CLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCTLFVPKCG 843
            |.||.|..|:|  |.||:|..||...|..|.|...::..:..||.:.|...:..|||:::.|.|.
Zfish    45 CEPITVPMCKG--IGYNHTYMPNQFNHDNQDEVGLEVHQFWPLVRIHCSPDLLFFLCSMYTPICL 107

  Fly   844 QS-GATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNC----------KLFKDFPSSEDCV---- 893
            |. ...:|||:::|....|.|......:|...||.::|          :|..|..|||...    
Zfish   108 QDYKKPLPPCRSVCERAKRGCSPLMIQYGFEWPERMSCEQLPMLGDTDRLCMDRNSSETTTLSPP 172

  Fly   894 -------GLDEVREVMRAATHPKCDGFQCDQNRCLPQEYVCDGHLDCMDQADEAKCERCGPDEIY 951
                   |....|...::|...|||           :|..|.|.|..:.:.......|       
Zfish   173 FPKPTPKGTPRHRATAKSAPPQKCD-----------RECHCRGPLVPIKKEAHPLHNR------- 219

  Fly   952 CGDSQCIGTKHICDGIIDC--PY-GQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWD 1013
                  :.|..:.:..:.|  || .||||               ....:.||.          | 
Zfish   220 ------VNTGSLPNCALPCHQPYFSQDER---------------TFTTFWIGL----------W- 252

  Fly  1014 RAVSPSAVCSILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDY 1078
                 |.:|.:..::.|               ||..:..:.:|.                     
Zfish   253 -----SVLCFVSTFTTV---------------ATFLIDMERFKY--------------------- 276

  Fly  1079 PMADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAA------------ILGGPEKIFYC 1131
                                 |.|.||           ||||            :|.|.|:: .|
Zfish   277 ---------------------PERPII-----------FLAACYLFVSLGYIVRLLAGHERV-AC 308

  Fly  1132 AGVLISDQ--------------WVLTASHCVGNYSVIDLEDWTIQLGVTRRNSFTY---SGQKVK 1179
            .|.  .||              .|....:..|..|.|    |.:.|      |||:   :|.|..
Zfish   309 EGT--GDQQHILYDTTGPALCTLVFLLIYFFGMASSI----WWVVL------SFTWFLAAGMKWG 361

  Fly  1180 VKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTLCTVIGWGKREDK 1244
            .:|:..:.||            |.||..:.            |||:::....|.:|       |.
Zfish   362 NEAIAGYSQY------------FHLAAWLV------------PSVKSIAVLALSSV-------DG 395

  Fly  1245 DPKSTYEYIVNE--------VQVPII 1262
            ||.:...|:.|:        |..|::
Zfish   396 DPVAGICYVGNQSLEGLRGFVLAPLV 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 39/136 (29%)
LDLa 911..942 CDD:238060 5/30 (17%)
LDLa 945..979 CDD:238060 8/36 (22%)
SR 980..>1034 CDD:214555 6/53 (11%)
Tryp_SPc 1104..1346 CDD:238113 42/196 (21%)
fzd5NP_571209.2 CRD_FZ5_like 44..163 CDD:143565 36/119 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..192 5/29 (17%)
7tmF_FZD5 235..546 CDD:320377 59/330 (18%)
TM helix 1 244..269 CDD:320377 8/55 (15%)
TM helix 2 278..299 CDD:320377 7/31 (23%)
TM helix 3 328..354 CDD:320377 9/35 (26%)
TM helix 4 371..387 CDD:320377 7/39 (18%)
TM helix 5 409..438 CDD:320377 2/13 (15%)
TM helix 6 458..485 CDD:320377
TM helix 7 507..532 CDD:320377
Blue background indicates that the domain is not in the aligned region.

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