DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Corin and smo

DIOPT Version :9

Sequence 1:NP_610297.2 Gene:Corin / 35691 FlyBaseID:FBgn0033192 Length:1397 Species:Drosophila melanogaster
Sequence 2:NP_571102.2 Gene:smo / 30225 ZFINID:ZDB-GENE-980526-89 Length:822 Species:Danio rerio


Alignment Length:231 Identity:50/231 - (21%)
Similarity:85/231 - (36%) Gaps:57/231 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   728 LINAFALLAIAGGLAAYFNAYPTIKFVNKTIINTIHVEDTTSFGKNPAPGTCLPIIVRFCQGPQI 792
            ::.:|.:|.|  ..|....|...|...|:||.|....:.|          ||..:....|.|..:
Zfish     9 IVGSFWMLWI--WTATSMVARAVILHPNETIFNDFCKKST----------TCEVLKYNTCLGSPL 61

  Fly   793 PYNYT--VFPNYIGHFGQLETQTDLDSYEALV-------DVRCYELVSLFLCTLFVPKCGQSGAT 848
            ||.:|  :...        :::|..:::|.|.       ..||:.::...||.:::||| ::|..
Zfish    62 PYTHTSLILAE--------DSETQEEAFEKLAMWSGLRNAPRCWAVIQPLLCAVYMPKC-ENGKV 117

  Fly   849 VPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFPSSEDCVGLDEVREVMRAATHPKCD-- 911
            ..|.:.||..|...|.......|  .|.:|.|:..:.||.     |.....:.::..|..:|:  
Zfish   118 ELPSQHLCQATRNPCSIVERERG--WPNFLKCENKEQFPK-----GCQNEVQKLKFNTSGQCEAP 175

  Fly   912 -----------------GFQCDQNRCLPQEYVCDGH 930
                             |.||| |....::...|.|
Zfish   176 LVKTDIQASWYKDVEGCGIQCD-NPLFTEDEHSDMH 210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CorinNP_610297.2 CRD_FZ 778..894 CDD:143549 29/124 (23%)
LDLa 911..942 CDD:238060 7/39 (18%)
LDLa 945..979 CDD:238060
SR 980..>1034 CDD:214555
SRCR 992..1086 CDD:278931
Tryp_SPc 1103..1343 CDD:214473
Tryp_SPc 1104..1346 CDD:238113
smoNP_571102.2 CRD_SMO 44..175 CDD:143560 33/156 (21%)
Frizzled 200..528 CDD:279827 2/11 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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