DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Tmprss13

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001121000.1	Gene:	Tmprss13 / 300682	RGDID:	1310872	Length:	539	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	126/402 - (31%)
Similarity:	192/402 - (47%)	Gaps:	54/402 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   961 KHI--CDGIIDCPYGQDERNCLRLSERNGDVGTGVLEVYRIGQRQWMPACVKNWDRAVSPSAVCS 1023
            ||.  |||::||....||..|:|.     |....:|:||.....:|:|.|..:|:...| ...|.
  Rat   178 KHAVRCDGVVDCKMKSDELGCVRF-----DWDKSLLKVYSGSSGEWLPVCSSSWNDTDS-ERTCQ 236

  Fly  1024 ILGYSAVNATSVLTQLTHRPLLATVNVSTDIWKMYAKRKSTLMQEFANCKKTEDYPMADLTCSNY 1088
            .||:.:...|   |::.||.:.::.        :.::..||: ||.....:........|.|::
  Rat   237 QLGFDSAYRT---TEVAHRDVTSSF--------LLSEYNSTI-QESLTRSECPSRRYVSLQCAH- 288

  Fly  1089 ECG-RVKRGRHKPSRRIIGGTQASPGNWPFLAAILGGPEKIFYCAGVLISDQWVLTASHCVGNYS 1152
             || |...|      ||:||...|...||:..::..|...|  |.|.||..||||||:||.....
  Rat   289 -CGLRAMTG------RIVGGALTSESKWPWQVSLHFGTTHI--CGGTLIDAQWVLTAAHCFFVTR 344

  Fly  1153 VIDLEDWTIQLGVTRRNSFTYSGQKVKVKAVIPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPV 1217
            ...||.|.:..|.:..:...   :...:..:|.:..|... ..|.||||.:|:..:....|:.|.
  Rat   345 EKILEGWKVYAGTSNLHQLP---EAASISQIIINGNYTDE-QDDYDIALVRLSKPLTLSAHIHPA 405

  Fly  1218 CLPPPSVRNLHPGTL-----CTVIGWGKREDKDPKSTYEYIVNEVQVPIITRNQCDEWL--DNLT 1275
            |||      ||..|.     |.:.|:||.::.|.|::  ..:.||||.:|...:|:::|  |:.
  Rat   406 CLP------LHGQTFGLNETCWITGFGKTKETDEKTS--PFLREVQVNLIDFKKCNDYLVYDSY- 461

  Fly  1276 VSEGMVCAGFDDGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMCAHPRLPGVYANVVQYV 1340
            ::..|:|||...||:|:|||||||||:|.   :.|||::.|:.|||..|.....||||..|.:.:
  Rat   462 LTPRMMCAGDLRGGRDSCQGDSGGPLVCE---QNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVL 523

  Fly  1341 PWIQEQIAKHSR 1352
            |||..::....|
  Rat   524 PWIYRKMESEVR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549
		LDLa	911..942	CDD:238060
		LDLa	945..979	CDD:238060	9/19 (47%)
		SR	980..>1034	CDD:214555	13/53 (25%)
		SRCR	992..1086	CDD:278931	20/93 (22%)
		Tryp_SPc	1103..1343	CDD:214473	86/246 (35%)
		Tryp_SPc	1104..1346	CDD:238113	87/248 (35%)
Tmprss13	NP_001121000.1	WWbp	<1..69	CDD:304964
		SRCR_2	203..292	CDD:292133	23/103 (22%)
		SRCR	216..288	CDD:278931	18/84 (21%)
		Tryp_SPc	297..526	CDD:214473	86/246 (35%)
		Tryp_SPc	298..526	CDD:238113	85/245 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3562
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960