DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Corin and Frzb

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001093997.1	Gene:	Frzb / 295691	RGDID:	1311315	Length:	323	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	65/290 - (22%)
Similarity:	109/290 - (37%)	Gaps:	79/290 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   776 PG----TCLPIIVRFCQGPQIPYNYTVFPNYIGHFGQLETQTDLDSYEALVDVRCYELVSLFLCT 836
            ||    .|.|:.:..|:  .:|:|.|..||::.|..|......::.:|.|:...|...:..|||.
  Rat    28 PGAQAAACEPVRIPLCK--SLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCA 90

  Fly   837 LFVPKC--GQSGATVPPCKTLCTETMRRCGFFFDVFGLSLPEYLNCKLFKDFP--------SSED 891
            ::.|.|  ......:.|||::|....:.|......:..|.||.|.|   ::.|        |.|.
  Rat    91 MYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLAC---EELPVYDRGVCISPEA 152

  Fly   892 CVGLDEVREVMRAAT-HPKCDGFQCDQNRCLP-----QEYVCDGHLDCMDQADEAKCERCGPDEI 950
            .|..|.....|.::| |  |.|...::.:|.|     :.|..:.:    :....||.:..   ::
  Rat   153 IVTADGADFPMDSSTGH--CRGTSSERCKCKPVRATQKTYFRNNY----NYVIRAKVKEV---KM 208

  Fly   951 YCGD-SQCIGTKHI-----------------CDGIIDCP------------YGQDERNCLRLSER 985
            .|.| :..:..|.|                 ..|.: ||            |..:||:.|.|.|.
  Rat   209 KCHDVTAIVEVKEILKASLVNIPRDTVNLYSTSGCL-CPPLSVNEEYVIMGYEDEERSRLLLVEG 272

  Fly   986 NGDVGTGVLEVY--RIGQRQWMPACVKNWD 1013
            :      :.|.:  |:|::      ||.||
  Rat   273 S------IAEKWKDRLGKK------VKRWD 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	31/125 (25%)
		LDLa	911..942	CDD:238060	5/35 (14%)
		LDLa	945..979	CDD:238060	10/63 (16%)
		SR	980..>1034	CDD:214555	10/36 (28%)
		SRCR	992..1086	CDD:278931	7/24 (29%)
		Tryp_SPc	1103..1343	CDD:214473
		Tryp_SPc	1104..1346	CDD:238113
Frzb	NP_001093997.1	CRD_SFRP3	32..157	CDD:143550	32/129 (25%)
Frzb	NP_001093997.1	NTR_Sfrp3_like	188..297	CDD:239636	23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900