DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Corin and Scart1

DIOPT Version :9

Sequence 1:	NP_610297.2	Gene:	Corin / 35691	FlyBaseID:	FBgn0033192	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001099782.1	Gene:	Scart1 / 293591	RGDID:	1307378	Length:	995	Species:	Rattus norvegicus

Alignment Length:	883	Identity:	188/883 - (21%)
Similarity:	255/883 - (28%)	Gaps:	335/883 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   644 LCS-----APAPIVCRQ--------GVQHEPIEELEPPQTISP-LHKAA--GQPSSLQTI---VR 689
            ||:     |.|.:||||        ..::.|:    |.:.:.| ||..:  |..|||...   ..
  Rat    56 LCNLEWTLAEASVVCRQLGCGPAVGAPKYVPL----PGEMVQPWLHNVSCWGNESSLWECSLGAW 116

  Fly   690 FQNGAPH---TMSLQHQIINRRKSSNPYITNGRLKFRLFQILINAFALLAIAGGLAAYFNAYPTI 751
            .|...||   .::|              ..||  .||..: |:...:..|   ||       |.|
  Rat   117 SQRACPHEWVVVAL--------------CANG--TFREIR-LVKGHSPCA---GL-------PEI 154

  Fly   752 KFVNKT-IINTIHVEDTTSFGKNPAPGTCLPI------IVRF--CQGPQIPYNYTVFPNYI---- 803
            :.||.. .:..:|||:.|.|.:....|..|..      :.::  |:|.:.........|.:
  Rat   155 RNVNGVDRLCGLHVEEATVFCRELECGHALQAPRQDVGVSKYMTCKGTEPTIRNCRLNNKLRGGC 219

  Fly   804 -----------GHF------------GQLET----------QTDLDSYEALVDVRCYEL-VSLFL 834
                       ||.            |:||.          ..|||...|  .|.|.|| ..:.:
  Rat   220 NLLLDAEVVCSGHVEARLVGGDHSCSGRLEVLRGLTWGTVCHADLDLPTA--HVICRELGCGMAV 282

  Fly   835 CTLFVPKCGQSGATV--PPCKTLCTETM---------RRCGFFFDVFGLSLPEYLNCKLFKDFPS 888
            .||...:.||....|  ...:.:..|:|         ..||...||       .|.|..|:....
  Rat   283 STLRGAQFGQGSGPVWLEAFRCVGNESMLFHCPQEPGHHCGHNQDV-------ALTCSEFRLVNG 340

  Fly   889 SEDCVGLDEVREVMRAATHPKCDG--------FQCDQNRC------LPQEYVCDGHLDCMDQADE 939
            |.||.|..|::  ::.|..|.|..        ..|.|..|      .|..:..||  |.....|.
  Rat   341 SSDCEGRVELQ--VQGAWAPLCAANWDLADAMVLCHQLNCGNAVSIPPGGHFGDG--DAPIWPDV 401

  Fly   940 AKCERCGPDEIYC-----GDSQCI---GTKHICDGIIDCPYGQDERNCLRLSERNG-DVGTGVLE 995
            ..|....|..::|     |...|:   ....||.|:.|         .|||  |:| ....|.:|
  Rat   402 FHCVGTEPHLLHCPASTLGAHSCVLGNTASTICSGLQD---------TLRL--RDGQSYCDGRVE 455

  Fly   996 VYRIGQRQWMPACVKNWDRAVSPSAVCSIL-------GYSA-----------VNATSVLTQLTHR 1042
            :...|  .|.......|| ....|.||..|       .|.|           ::....|...||
  Rat   456 ISLNG--SWGRVLDDIWD-IRGASVVCRQLECGEAQGAYDAPAPGFRTAPVGLSQVRCLGSETH- 516

  Fly  1043 PLLATVNVSTDIWKMYAKRK--------STLMQEFAN-------------------CKKTEDYPM 1080
              |...||||.:....|..:        |..|:..|.                   |....|...
  Rat   517 --LMQCNVSTSLLVPAATLRDAGVVCSGSLRMRLAAGPGRCAGRVEVFYQGSWGTVCDDAWDLQD 579

  Fly  1081 ADLTCSNYECGRVKRGRHKPSRRIIGGTQASPGNWPFLAA----------ILGGPEKIFYC---- 1131
            |.:.|...:||.               ..::|||..|.|.          .||....::.|
  Rat   580 AQVVCRQLDCGH---------------ALSAPGNAHFGAGTGRIWMDELHCLGNESLLWKCQSGN 629

  Fly  1132 -----------AGVLISDQWVLT----ASHCVGNYSVIDLEDWTIQLGVTRRNSFTYSGQKVKVK 1181
                       |||..|:...|.    .|.|||...|:....|    |....|:.......:..:
  Rat   630 WGQHDCRHKEDAGVFCSESVALRLRGGTSGCVGWLDVLYNGSW----GAVCSNALRDISLSIMCR 690

  Fly  1182 AV----------IPHPQYNMAIAHDNDIALFQLATRVAFHEHLLPVCLPPPSVRNLHPGTL--CT 1234
            .:          .|.|...:.|:..:.|                       ..|.||..||  |.
  Rat   691 QLGCGDQGWLENRPSPGPGLGISWVDKI-----------------------KCRKLHNATLWQCP 732

  Fly  1235 VIGWGKREDKDPKS-TYEYIVNEV------------QVPIITRNQCDEWLDNLTVSEGMVCAGFD 1286
            ...|      :|.| |.|   .||            |.|..|.| |...|..|..|...|.
  Rat   733 SAPW------NPHSCTQE---EEVWINCEGLPQIGSQEPAQTPN-CSSPLGCLEDSVLRVL---- 783

  Fly  1287 DGGKDACQGDSGGPLLCPYPGEKNRWFVGGIVSWGIMC 1324
             ||:|.|.            |....|..|   |||.:|
  Rat   784 -GGEDGCS------------GRVELWHAG---SWGTVC 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Corin	NP_610297.2	CRD_FZ	778..894	CDD:143549	34/172 (20%)
		LDLa	911..942	CDD:238060	8/44 (18%)
		LDLa	945..979	CDD:238060	8/41 (20%)
		SR	980..>1034	CDD:214555	17/72 (24%)
		SRCR	992..1086	CDD:278931	27/138 (20%)
		Tryp_SPc	1103..1343	CDD:214473	58/276 (21%)
		Tryp_SPc	1104..1346	CDD:238113	58/275 (21%)
Scart1	NP_001099782.1	SR	32..131	CDD:214555	21/92 (23%)
		SRCR	39..132	CDD:278931	21/93 (23%)
		SRCR	144..230	CDD:278931	17/95 (18%)
		SR	236..333	CDD:214555	23/105 (22%)
		SRCR	240..333	CDD:278931	23/101 (23%)
		SR	336..435	CDD:214555	22/102 (22%)
		SRCR	340..435	CDD:278931	22/98 (22%)
		SR	441..541	CDD:214555	26/107 (24%)
		SRCR	446..541	CDD:278931	22/100 (22%)
		SR	546..646	CDD:214555	19/114 (17%)
		SRCR	551..646	CDD:278931	17/109 (16%)
		SRCR	656..751	CDD:278931	25/130 (19%)
		SR	780..879	CDD:214555	12/46 (26%)
		SRCR	785..880	CDD:278931	10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000